Article
Engineering, Electrical & Electronic
Leila Sohrabi-Kashani, Bijan Eftekhari Yekta, Hamid Reza Rezaie, Ashkan Zolriasatein
Summary: This study compares the hydrophobic, mechanical, and electrical properties of polymer coatings reinforced with ceramic particles. The results indicate that the use of modified titanium dioxide can significantly improve the contact angle, mechanical strength, elongation, and electrical resistivity of the material.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Nanoscience & Nanotechnology
Yuehuang Wu, Min Zhou, Ruimiao Lin, Lixue Yu, Xiaokun Zhang, Jingjing Xie
Summary: This study developed multiarm PEG-gated large pore-sized mesoporous silica nanoparticles for the delivery and release of biomacromolecules, aiming to treat drug-resistant tumors. By combining the N9 peptide payload with celastrol integration, synergistic effects were achieved, resulting in enhanced therapeutic outcomes in both resistant cancer cell lines and xenografted mice models.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yongzhi Wu, Fangman Chen, Nengwen Huang, Jinjin Li, Chenzhou Wu, Bowen Tan, Yunkun Liu, Longjiang Li, Chao Yang, Dan Shao, Jinfeng Liao
Summary: Light-stimulus-responsive hydrogels incorporating mesoporous silica nanoparticles as doxorubicin carriers were developed for on-demand chemo-photothermal therapy of OSCC. The combination of chemotherapy and phototherapy achieved a long-lasting synergistic anti-tumor effect with less toxicity in vitro and in vivo.
Article
Biophysics
Weixia Xu, Min Zhou, Zhihan Guo, Sijin Lin, Mingyu Li, Qi Kang, Yang Xu, Xiaokun Zhang, Jingjing Xie
Summary: The study demonstrated that the tumor penetration and toxicity effects of mesoporous silica nanoparticles (MSNs) for cancer treatment are influenced by particle sizes. The 50 nm particles showed better tumor accumulation and retention, as well as lower toxicity compared to the 20 nm particles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Brigida Silvestri, Paolo Armanetti, Giulio Pota, Giuseppe Vitiello, Alessandro Pezzella, Luca Menichetti, Vincenzo Giannini, Giuseppina Luciani
Summary: Photoacoustics is an increasingly recognized biomolecular imaging technique due to its non-invasiveness, deep penetration, high spatial resolution, and excellent endogenous contrast. Recent research has shown that a self-structured biocompatible nanoprobe, consisting of ternary hybrid nanoparticles with a silver core and a melanin component embedded into a silica matrix, exhibits excellent photoacoustic response. The interaction between eumelanin and silver is found to play an important role in the in situ-generated metal-organic interface. By systematically varying the metal/melanin component, the stability and intensity of the photoacoustic response can be tuned for various biomedical and theranostic applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Ozgun Daglar, Emrah Cakmakci, Ufuk Saim Gunay, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: The study focused on developing innovative routes for hybrid polymer nanocomposite preparation using click chemistry reactions. Modified silica nanoparticles showed uniform dispersion in the polymer matrix, leading to enhancements in modulus and T-g values in the prepared hybrid nanocomposites. The gel content of the hybrid nanocomposites reached nearly 88%, confirming their successful formation.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Materials Science, Ceramics
Barbara Di Credico, Elisa Manzini, Lorenzo Vigano, Carmen Canevali, Massimiliano D'Arienzo, Silvia Mostoni, Roberto Nistico, Roberto Scotti
Summary: This article systematically reviews the use of silica nanoparticles (Si-NPs) in polymer nanocomposites (NCs) and the role of NPs self-assembly in determining the final material properties. The dispersion and distribution of NPs, as well as the functionalization strategies of Si-NPs, are discussed. The self-organization of Si-NPs and Si-HNPs in polymer matrices and their effects on functional material properties are evaluated.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Bakhta Aouey, Khadija Boukholda, Brahim Gargouri, Harsharan S. Bhatia, Abdelraheim Attaai, Mohamed Kebieche, Michele Bouchard, Hamadi Fetoui
Summary: The study demonstrated that silica nanoparticles (SiNPs) could induce liver damage in rats, as evidenced by abnormal liver function markers, increased oxidative stress, decreased antioxidant enzyme activities, altered expression of apoptosis-related genes, and changes in hepatic histopathology.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Hang Xu, Gang Sheng, Lu Lu, Cuirong Wang, Yu Zhang, Lili Feng, Lingtong Meng, Pengxiang Min, Li Zhang, Yijun Wang, Feng Han
Summary: A novel nanotherapy platform combining photothermal and photodynamic therapy was developed for the treatment of castration resistance prostate cancer. The platform demonstrated significant therapeutic effects in vitro and good biocompatibility in vivo, showing promise for high-efficient treatment of prostate cancer.
Article
Pharmacology & Pharmacy
Yanyan Zhang, Jiadong Lou, Gareth R. Williams, Yuhan Ye, Dandan Ren, Anhua Shi, Junzi Wu, Wenling Chen, Li-Min Zhu
Summary: In this study, pH-responsive mesoporous silica nanoparticles (MSN) were developed for targeted and synergistic anticancer therapy. The MSNs, functionalized with a histidine-tagged targeting peptide, showed pH-responsive drug release and effectively targeted tumor cells. The presence of an anticancer drug and Cu2+ enhanced the chemotherapeutic effect by generating reactive oxygen species. In vitro and in vivo experiments demonstrated the effective killing of tumor cells and diminished tumor volume without off-target toxicity. The functionalized MSNs show great potential for targeted and synergistic anticancer therapies.
Article
Polymer Science
Sofia F. Cabrera, Agustina Pighin, Martin L. Chiana, Mario C. G. Passeggi, Gustavo D. Ruano, Luis M. Gugliotta, Ludmila Ronco, Roque J. Minari
Summary: The growing environmental concerns and depletion of oil reserves have led to the development of novel eco-friendly and biodegradable materials. This study focuses on the use of biopolymers as replacements for petroleum-based polymers, and presents a new class of waterborne acrylic/biopolymer nanoparticles produced through emulsion polymerization. The nanoparticles exhibited favorable film formation capability and controlled mechanical properties, making them potentially suitable for coatings and adhesives.
JOURNAL OF POLYMER SCIENCE
(2022)
Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biophysics
Shixuan Su, Ting Yu, Jing Hu, Yunlei Xianyu
Summary: A bio-inspired strategy for plasmonic detection of ACE was developed using peptide-mediated assembly of gold nanoparticles, enabling rapid, sensitive, and selective detection of ACE. This biosensor allows naked-eyed readout of ACE detection with great selectivity and high sensitivity. The technique holds great promise as a point-of-care platform for biomedical diagnostics and the food industry.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Huan Chen, Lei Shao, Junchao Ma, Jun Zhou, Yu Fu
Summary: The template-directed strategy is a facile and universal method for synthesizing novel and useful functional materials. In this study, a ternary hybrid Cu2O/Cu/Au with a hollow structure is synthesized using a two-step template-directed strategy. The resulting material exhibits enhanced electrochemical catalytic activity and can be used as a highly sensitive H2O2 sensor with a wide detection range and low limit of detection.
Article
Polymer Science
Mariapaola Staropoli, Vincent Roge, Enzo Moretto, Joffrey Didierjean, Marc Michel, Benoit Duez, Pascal Steiner, Georges Thielen, Damien Lenoble, Jean-Sebastien Thomann
Summary: The study investigates the synergistic effect of dual silica-based fillers in SBR/PBD rubber matrix, showing that anisotropic fillers align only in the presence of a critical amount of HDS, leading to increased stiffness of the nanocomposite, while spherical 250 nm nanoparticles inhibit percolation network and reduce stiffness.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
