Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 69, Issue 3, Pages 325-342Publisher
SPRINGER
DOI: 10.1007/s00262-019-02461-2
Keywords
B lymphocyte; Non-small-cell lung cancer (NSCLC); Humoral Immunity; Immunoglobulin; Tumour -infiltrating B lymphocyte (TIL-B)
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Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.
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