Treatment with an immature dendritic cell-targeting vaccine supplemented with IFN-α and an inhibitor of DNA methylation markedly enhances survival in a murine melanoma model

Powerful Anticolon Tumor Effect of Targeted Gene Immunotherapy Using Folate-Modified Nanoparticle Delivery of CCL19 To Activate the Immune System

(2019) Xiaoxiao Liu et al.   ACS Central Science

Accumulation of Circulating CCR7+ Natural Killer Cells Marks Melanoma Evolution and Reveals a CCL19-Dependent Metastatic Pathway

(2019) Costanza Maria Cristiani et al.   Cancer Immunology Research

CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses

(2018) Hung-Wei Cheng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity

(2018) Victor H. Engelhard et al.   JOURNAL OF IMMUNOLOGY

Anti-IL-10–mediated Enhancement of Antitumor Efficacy of a Dendritic Cell–targeting MIP3α-gp100 Vaccine in the B16F10 Mouse Melanoma Model Is Dependent on Type I Interferons

(2018) James T. Gordy et al.   JOURNAL OF IMMUNOTHERAPY

Abstract 726: Type-I interferon and epigenetic modulators enhance the anti-tumor efficacy of a dendritic-cell targeting MIP3α-antigen vaccine in the B16F10 mouse model

(2018) James Gordy et al.   CANCER RESEARCH

33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018)

(2018)   Journal for ImmunoTherapy of Cancer

Combining Type I Interferons and 5-Aza-2′-Deoxycitidine to Improve Anti-Tumor Response against Melanoma

(2017) Valeria Lucarini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Extended protection capabilities of an immature dendritic-cell targeting malaria sporozoite vaccine

(2017) Kun Luo et al.   VACCINE

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy

(2017) Yohsuke Yagawa et al.   Scientific Reports

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

(2016) M. A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

Fusion of the dendritic cell-targeting chemokine MIP3α to melanoma antigen Gp100 in a therapeutic DNA vaccine significantly enhances immunogenicity and survival in a mouse melanoma model

(2016) James T. Gordy et al.   Journal for ImmunoTherapy of Cancer

DNA methyltransferase inhibitors in acute myeloid leukemia: discovery, design and first therapeutic experiences

(2016) Xavier Thomas   Expert Opinion on Drug Discovery

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Decitabine, a new star in epigenetic therapy: the clinical application and biological mechanism in solid tumors

(2014) Jing Nie et al.   CANCER LETTERS

Vaccines and Melanoma

(2014) Patrick A. Ott et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Fusion of Antigen to a Dendritic Cell Targeting Chemokine Combined with Adjuvant Yields a Malaria DNA Vaccine with Enhanced Protective Capabilities

(2014) Kun Luo et al.   PLoS One

Epigenetics of melanoma: implications for immune-based therapies

(2013) Elisabetta Fratta et al.   Immunotherapy

Melanoma immunotherapy: historical precedents, recent successes and future prospects

(2013) Marieke IG Raaijmakers et al.   Immunotherapy

Overexpression of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 in human primary cutaneous melanoma: a potential prognostic value for CCR7 and CCR10?

(2012) Laura Kühnelt-Leddihn et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

CCL19 as an adjuvant for intradermal gene gun immunization in a Her2/neu mouse tumor model: improved vaccine efficacy and a role for B cells as APC

(2012) T Nguyen-Hoai et al.   CANCER GENE THERAPY

CCL19 (ELC) improves TH1-polarized immune responses and protective immunity in a murine Her2/neu DNA vaccination model

(2012) Tam Nguyen-Hoai et al.   JOURNAL OF GENE MEDICINE

12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?

(2012) Jane L. Messina et al.   Scientific Reports

Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients

(2012) A.J. Robert McGray et al.   OncoImmunology

Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery

(2011) Zhiping Zhang et al.   BIOMATERIALS

Design of immunogenic and effective multi-epitope DNA vaccines for melanoma

(2011) Hyun-Il Cho et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Present and Future of Peptide Vaccines for Cancer

(2011) Craig L. Slingluff   CANCER JOURNAL

Improved immune responses in mice using the novel chitosan adjuvant ViscoGel, with a Haemophilus influenzae type b glycoconjugate vaccine

(2011) Theresa Neimert-Andersson et al.   VACCINE

The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA

(2010) Peter Öhlschläger et al.   INTERNATIONAL JOURNAL OF CANCER

Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication

(2009) J. K. Damås et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IFN-  Enhances Peptide Vaccine-Induced CD8+ T Cell Numbers, Effector Function, and Antitumor Activity

(2009) A. G. Sikora et al.   JOURNAL OF IMMUNOLOGY

Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery

(2009) Simon R. Best et al.   VACCINE

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER