Review
Biochemistry & Molecular Biology
Sarah K. Madden, Aline Dantas de Araujo, Mara Gerhardt, David P. Fairlie, Jody M. Mason
Summary: Direct inhibition of c-Myc, a transcription factor overexpressed in many human cancers, has shown promising results in triggering tumor regression with reversible side effects. Challenges and lessons from current inhibitors are evaluated to explore future strategies for translating c-Myc inhibitors into clinical practice, such as miniaturisation of Omomyc and targeting E-box binding.
Article
Multidisciplinary Sciences
Ashley A. Hardeman, Yoo Jane Han, Tatyana A. Grushko, Jeffrey Mueller, Maria J. Gomez, Yonglan Zheng, Olufunmilayo I. Olopade
Summary: This study found that MELK gene expression is highly upregulated in aggressive forms of breast cancer, particularly in basal-like breast cancer (BLBC). The increase in MELK expression appears to be driven by gene copy number gains rather than epigenetic modifications. The findings suggest that MELK overexpression and copy number gains could be potential diagnostic and prognostic markers for identifying patients with more aggressive breast cancer.
Article
Cell Biology
Haitao Yang, Xiao Feng, Xiangdong Tong
Summary: The expression and function of lncRNA POU6F2-AS2 in nonsmall-cell lung cancer (NSCLC) were investigated in this study. It was found that POU6F2-AS2 was highly expressed in NSCLC and acted as an oncogene by targeting the miR-125b-5p/E2F3 axis. These findings suggest that POU6F2-AS2 may serve as a therapeutic target for NSCLC.
Article
Biotechnology & Applied Microbiology
Ruliang Ding, Weiwen Hong, Liang Huang, Jinfan Shao, Wenfeng Yu, Xijuan Xu
Summary: MicroRNA-145-5p represses colon cancer cell cycle progression and cell proliferation by targeting PSAT1.
Article
Oncology
Luhong Li, Peipei Chen, Bingbing Huang, Peiya Cai
Summary: This study identified that DSCAM-AS1 is highly expressed in endometrial cancer and is associated with poor overall survival in patients. Knockdown of DSCAM-AS1 suppressed cell proliferation by promoting apoptosis and acted as a sponge for miR-136-5p to exert its oncogenic roles in endometrial cancer.
Article
Biochemistry & Molecular Biology
Xiaoming Yang, Xiaosong Wei, Chengzhi Yi, Yang Yang, Zhiwei Fang, Yuanheng Dai, Yufeng Guo, Dongkui Song
Summary: Bladder cancer (BC) is the most common malignant tumor in the genitourinary system. This study found that HAND2-AS1 is downregulated in BC tissues and its overexpression inhibited malignant behaviors of BC cells. Further investigation revealed that HAND2-AS1 acts as a suppressor in BC development through the modulation of miR-17-5p/KLF9 axis.
DNA AND CELL BIOLOGY
(2022)
Article
Oncology
Jie Wang, Changjiang Lei, Pingping Shi, Huaixiang Teng, Lixiang Lu, Hailong Guo, Xiuqin Wang
Summary: The study identified a novel lncRNA DCST1-AS1 highly upregulated in EC, which promoted EC progression by regulating the expression of HOXB5 and CADM1. DCST1-AS1 may serve as a potential therapeutic target for EC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Chan Zhang, Shangjie Wu, Rong Song, Changming Liu
Summary: The high expression of NR2F1-AS1 in NSCLC promotes tumor cell proliferation, migration, and invasion while interacting with the miR-493-5p/ITGB1 pathway to drive tumor progression. NR2F1-AS1 may serve as a potential molecular target for anticancer therapy in NSCLC.
Article
Oncology
Camila Meirelles S. Silva, Mateus C. Barros-Filho, Deysi Viviana T. Wong, Julia Bette H. Mello, Livia Maria S. Nobre, Carlos Wagner S. Wanderley, Larisse T. Lucetti, Heitor A. Muniz, Igor Kenned D. Paiva, Hellen Kuasne, Daniel Paula P. Ferreira, Maria Perpetuo S. S. Cunha, Carlos G. Hirth, Paulo Goberlanio B. Silva, Rosane O. Sant'Ana, Marcellus Henrique L. P. Souza, Josiane S. Quetz, Silvia R. Rogatto, Roberto Cesar P. Lima-Junior
Summary: By screening miRNAs in plasma, we identified four miRNAs as potential biomarkers for the early detection of colorectal cancer, presenting high performance and easy applicability in clinical practice.
Article
Oncology
Christos Miliotis, Frank J. Slack
Summary: In gastric cancer, miR-105-5p has been identified as a key regulator of PD-L1 expression, impacting T cell activation, and could serve as a potential biomarker and target for combination immunotherapy targeting PD-1/PD-L1 interactions.
Article
Oncology
Yuhong Liu, Gang Xu, Lin Li
Summary: The study demonstrates that GATA3-AS1 plays a crucial role in tumorigenesis of pancreatic cancer through regulating the miR-30b-5p-Tex10 axis, potentially involving the Wnt/beta-catenin signaling pathway.
Article
Biotechnology & Applied Microbiology
Xuan Cui, Shisan Zhou, Yongtao Lin
Summary: This study reveals the mechanism of DHRS4 antisense RNA 1 (DHRS4-AS1) in endometriosis, showing that DHRS4-AS1 inhibits cell proliferation, migration, and invasion, and promotes apoptosis by targeting miR-139-5p.
Article
Medicine, Research & Experimental
Dandan Zhu, Weize Lv, Xiao Zhou, Yu He, Hongbin Yao, Yinxin Yu, Guodong Zhang, Qingyuan Zhang
Summary: In this study, increased expression of TMPO-AS1 was observed in breast cancer tissues and cells, and TMPO-AS1 knockdown significantly inhibited breast cancer cell viability and migration. TMPO-AS1 was found to promote cellular viability and migration by acting as a competing endogenous RNA by sponging miR-140-5p.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoling Geng, Haoyu Wang, Lichen Xu, Yazhou Han, Yadong Liu
Summary: In osteosarcoma patients, plasma levels of microRNA-140-5p were significantly lower while plasma levels of GLUT-1 were significantly higher compared to healthy controls. The plasma levels of microRNA-140-5p were negatively correlated with GLUT-1 levels in osteosarcoma patients. The overexpression of microRNA-140-5p inhibited cancer cell proliferation, while the overexpression of GLUT-1 promoted cancer cell proliferation.
ONCOTARGETS AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Shu Xu, San-Lin Lei, Kui-Jie Liu, Shen-Gen Yi, Zhu-Lin Yang, Hong-Liang Yao
Summary: Pancreatic cancer (PC) is a common and lethal cancer with poor prognosis and limited treatment options. This study found that circSFMBT1 and PAK1 were up-regulated, while miR-330-5p was down-regulated in PC tissues and cells, promoting proliferation and metastasis of PC cells through the regulation of the miR-330-5p/PAK1 pathway.
CANCER GENE THERAPY
(2021)