Article
Orthopedics
Julia M. Stone, Amit Pujari, John Garlich, Carol Lin
Summary: The purpose of this study is to identify the risk factors for prolonged opioid use after surgery in geriatric hip fracture patients and the effects of prolonged use on mortality and readmission rates. The study found that patients who had previous opioid exposure and patients who were on antidepressants were more likely to continue opioid use at 6 months. Previous opioid exposure was associated with mortality.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Rehabilitation
Aaron P. Turner, Anne Arewasikporn, Eric J. Hawkins, Pradeep Suri, Stephen P. Burns, Steve L. Leipertz, Jodie K. Haselkorn
Summary: This study aimed to characterize patterns of prescription opioid use in individuals with multiple sclerosis (MS) and identify risk factors associated with chronic use. The results showed a decline in chronic opioid use over the study period, but it remains common among a substantial minority of MS patients. Prior chronic opioid use, history of pain condition, post-traumatic stress disorder, and rural residence were associated with a greater risk of chronic prescription opioid use.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Denis Agniel, Gabriel A. Brat, Jayson S. Marwaha, Kathe Fox, Daniel Knecht, Harold L. Paz, Mark C. Bicket, Brian Yorkgitis, Nathan Palmer, Isaac Kohane
Summary: This cohort study found that family members of patients who received prescription opioid refills after surgery had an increased risk of opioid misuse and chronic opioid use.
Article
Clinical Neurology
Mohamed Abdelwahab, Sandro Marques, Javier Howard, Allen Huang, Matt Lechner, Cristen Olds, Robson Capasso
Summary: This study aimed to assess the incidence and risk factors of chronic opioid use after obstructive sleep apnea surgery. The results showed that perioperative opioid prescription and smoking were independent risk factors for inappropriate opioid use, while opioid prescription and hypertension were risk factors for persistent opioid use.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Review
Neurosciences
Arbi Nazarian, S. Stevens Negus, Thomas J. Martin
Summary: Pain is a complex experience influenced by biological, psychological, and social factors, which can increase susceptibility to opioid use disorder. Chronic pain and opioid use disorder often co-occur, driven by increased availability of opioid analgesics for non-medical use. Brain imaging studies suggest mechanisms related to opioid abuse in individuals with chronic pain who use opioids.
Article
Substance Abuse
Jordan P. Davis, David Eddie, John Prindle, Emily R. Dworkin, Nina C. Christie, Shaddy Saba, Graham T. DiGuiseppi, John D. Clapp, John F. Kelly
Summary: The study found that risk factors for relapse to opioid use following treatment for opioid use disorder are mainly related to substance use problems and withdrawal symptoms in women, while in men they are mainly related to age, conduct disorder symptoms, and history of multiple substance use disorders.
Article
Clinical Neurology
Alis J. Dicpinigaitis, Eric Feldstein, Nitesh Damodara, Jared B. Cooper, Steven D. Shapiro, Haris Kamal, Merritt D. Kinon, Jared Pisapia, Jon Rosenberg, Chirag D. Gandhi, Fawaz Al-Mufti
Summary: This study used data from a national inpatient registry to investigate the incidence, risk factors, and clinical associations of posttraumatic vasospasm (PTV) in patients with traumatic intracranial hemorrhage (tICH). The results identified several clinical factors, such as age, admission Glasgow Coma Scale score, intraventricular hemorrhage, tobacco smoking, cocaine use, fever, and hypokalemia, that were independently associated with the development of PTV. Furthermore, the study found that the development of vasospasm was associated with poorer neurological outcomes.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
Hilmi Alnsasra, Rabea Asleh, Neeraj Kumar, Camden Lopez, Takumi Toya, Walter K. Kremers, Brooks Edwards, Richard C. Daly, Sudhir S. Kushwaha
Summary: Stroke after heart transplantation is associated with increased mortality. Older age, diabetes, renal dysfunction, and CMV infection are risk factors for stroke.
Article
Ophthalmology
Cindy Ung, Yoshihiro Yonekawa, Jennifer F. Waljee, Vidhya Gunaseelan, Yen-Ling Lai, Maria A. Woodward
Summary: In patients who underwent ophthalmic surgery, the rate of new persistent opioid use was 3.4% in those who had prior opioid exposure compared to 0.6% in opioid-naive patients. For patients who had an initial perioperative opioid prescription, a prescription size of 150 morphine milligram equivalents or more was associated with an increased odds of refill.
Article
Chemistry, Medicinal
Matthew S. Ellis, Zachary A. Kasper, Mark Gold, Theodore J. Cicero
Summary: The study found that most patients had low awareness of the risks associated with taking opioids, with some not having discussed the risks with their doctors. In addition to dose-response relationship, organizations should focus on enhancing patient education on overdose risk and evaluating behaviors or characteristics that may increase an individual's risk of opioid overdose.
Article
Surgery
Teresa M. Bell, Jodi L. Raymond, Alejandro C. Mongalo, Zachary W. Adams, Thomas M. Rouse, LeRanna Hatcher, Katie Russell, Aaron E. Carroll
Summary: This study found that the number of outpatient opioid prescriptions during the recovery period of injured adolescents was associated with future SUD diagnoses and overdose. Short-term prescriptions had the greatest effect on developing an SUD in the early stages of recovery, while long-term prescription use was linked to future overdose.
Review
Clinical Neurology
Shruthi Mohan, Conor P. Lynch, Elliot D. K. Cha, Kevin C. Jacob, Madhav R. Patel, Cara E. Geoghegan, Michael C. Prabhu, Nisheka N. Vanjani, Hanna Pawlowski, Kern Singh
Summary: This study conducted a systematic review and meta-analysis to identify significant preoperative risk factors for prolonged postoperative opioid use following spine surgery. Factors such as preoperative opioid use, depression, anxiety, drug abuse or dependency, female gender, fibromyalgia, lower back pain, tobacco use, and chronic pulmonary disease were found to be statistically significant risk factors for prolonged opioid use.
WORLD NEUROSURGERY
(2022)
Article
Multidisciplinary Sciences
Scott G. Weiner, Michelle A. Hendricks, Sanae El Ibrahimi, Grant A. Ritter, Sara E. Hallvik, Christi Hildebran, Roger D. Weiss, Edward W. Boyer, Diana P. Flores, Lewis S. Nelson, Peter W. Kreiner, Michael A. Fischer
Summary: This study examined the risks of chronic use and overdose associated with hydrocodone and oxycodone in opioid-naive patients following their initial prescription. The results showed that hydrocodone had a slightly higher risk of chronic use, while oxycodone, especially when used in monotherapy, posed a higher risk of overdose. This suggests that hydrocodone may be a preferable choice to reduce overdose-related deaths.
Article
Cardiac & Cardiovascular Systems
Josef Madrigal, Yas Sanaiha, Joseph Hadaya, Puneet Dhawan, Peyman Benharash
Summary: This study found that the prevalence of opioid use disorder among cardiac surgical patients has significantly increased over the past decade. While the presence of OUD was not associated with increased mortality during the index hospitalization, it was predictive of 30-day readmission. Increased focus on predischarge interventions and care coordination may help improve outcomes in this population.
Article
Geriatrics & Gerontology
Mingyang Sun, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang
Summary: This study investigated the association between long-term opioid use and the risk of dementia in patients with chronic pain. The results showed that long-term opioid use may be associated with an increased risk of dementia. These findings highlight the need for cautious prescribing and monitoring of opioid use in this population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Surgery
D. Nepogodiev, Omar M. Omar, James C. Glasbey, Elizabeth Li, Joana F. F. Simoes, Tom E. F. Abbott, Adesoji O. Ademuyiwa, Bruce M. Biccard, Daoud Chaudhry, Giana H. Davidson, Salomone Di Saverio, Gaetano Gallo, Dhruv Ghosh, Ewen M. Harrison, Peter J. Hutchinson, Haytham M. A. Kaafarani, Sivesh K. Kamarajah, Deborah S. Keller, Ismail Lawani, Ana Minaya-Bravo, Rachel Moore, Dion G. Morton, Faustin Ntirenganya, Francesco Pata, Rupert M. Pearse, Antonio Ramos-De la Medina, Stephen Tabiri, Mary L. Venn, Aneel Bhangu, Kwabena Siaw-Acheampong, Michel Adamina, Arnav Agarwal, Ehab Alameer, Derek Alderson, Felix Alakaloko, Osaid Alser, Alexis P. Arnaud, Knut Magne Augestad, Brittany K. Bankhead-Kendall, Emma Barlow, Ruth A. Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A. Breen, Igor Lima Buarque, Edward J. Caruana, Sohini Chakrabortee, Daniel Cox, Miguel F. Cunha, Brett E. Dawson, Anant Desai, Thomas D. Drake, John G. Edwards, Muhammed Elhadi, Jonathan P. Evans, Shebani Farik, Marco Fiore, J. Edward Fitzgerald, Samuel Ford, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Ewen A. Griffiths, Rohan R. Gujjuri, Constantine Halkias, Emily Heritage, Arda Isik, Michael D. Jenkinson, Conor S. Jones, Chetan Khatri, James M. Keatley, Angelos Kolias, Samuel Lawday, Hans Lederhuber, Sezai Leventoglu, Markus W. Löffler, Janet Martin, Hassan N. Mashbari, Dennis Mazingi, Siobhan C. Mckay, Symeon Metallidis, Helen M. Mohan, David Moszkowicz, Susan Moug, Joshua S. Ng-Kamstra, Milagros Niquen, Oumaima Outani, Gianluca Pellino, Thomas D. Pinkney, Peter Pockney, Dejan Radenkovic, Keith Roberts, April C. Roslani, Irene Santos, Andrew Schache, Andreas A. Schnitzbauer, Grant D. Stewart, Richard Shaw, Sebastian Shu, Kjetil Soreide, Antonino Spinelli, Sudha Sundar, Abhinav Tiwari, Philip Townend, Isobel M. Trout, Georgios Tsoulfas, Gabrielle H. van Ramshorst, Raghavan Vidya, Dale Vimalachandran, Oliver Warren, Richard J. W. Wilkin, Naomi Wright, Andreas Hoeft, Andrew Rhodes, Benoit Vallet, Brigitte Leva, Claudia Spies, Jean-Louis Vincent, Kim Golder, Marta Januszewska, Paolo Pelosi, Peter Bauer, Philipp Metnitz, Rui Moreno, Rupert Pearse, Russell Hewson, Sandrine Damster, Vasco Ramos, Eric Hoste, Luc Huyghens, Rita Jacobs, Veerle Van Mossevelde, Godelieve Opdenacker, Jan Poelaert
BRITISH JOURNAL OF SURGERY
(2020)
Article
Critical Care Medicine
Liesbet De Bus, Pieter Depuydt, Johan Steen, Sofie Dhaese, Ken De Smet, Alexis Tabah, Murat Akova, Menino Osbert Cotta, Gennaro De Pascale, George Dimopoulos, Shigeki Fujitani, Jose Garnacho-Montero, Marc Leone, Jerey Lipman, Marlies Ostermann, Jose-Artur Paiva, Jeroen Schouten, Fredrik Sjovall, Jean-Francois Timsit, Jason A. Roberts, Jean-Ralph Zahar, Farid Zand, Kapil Zirpe, Jan J. De Waele
INTENSIVE CARE MEDICINE
(2020)
Article
Anesthesiology
Anca Balintescu, Ida Palmgren, Miklos Lipcsey, Anders Oldner, Anders Larsson, Maria Cronhjort, Marcus Lind, Jan Wernerman, Johan Martensson
Summary: In four tertiary Swedish ICUs, one-third of patients had chronic dysglycemia, leading to significant abnormalities in glycemic control and an increased need for renal replacement therapy.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2021)
Article
Anesthesiology
Emma Larsson, Olof Brattstrom, Christina Agvald-Ohman, Jonathan Grip, Francesca Campoccia Jalde, Kristoffer Stralin, Pontus Naucler, Anders Oldner, David Konrad, Bjorn P. Persson, Lars I. Eriksson, Johan Martensson
Summary: This study provides detailed data on the clinical characteristics and early outcomes of consecutive patients with COVID-19 admitted to ICU in a large tertiary hospital in Sweden. Among ICU patients, the majority were male, had comorbidities, and the median duration of symptoms preceding ICU admission was 11 days.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2021)
Article
Critical Care Medicine
Erik von Oelreich, Mikael Eriksson, Karl-Fredrik Sjolund, Andrea Discacciati, Emma Larsson, Anders Oldner
Summary: A retrospective cohort study in Sweden found that approximately 22,138 patients developed chronic opioid use following ICU admission, with opioid consumption peaking after admission and gradually declining over a 24-month follow-up period. Factors associated with chronic opioid use included high age, female sex, presence of comorbidities, preadmission opioid use, and ICU length of stay greater than 2 days. The study also revealed an increased risk of death for chronic opioid users 6-18 months after admission, emphasizing the importance of preventing opioid misuse for improving long-term outcomes after critical care.
CRITICAL CARE MEDICINE
(2021)
Article
Anesthesiology
Michel Hanna, Anca Balintescu, Neil Glassford, Miklos Lipcsey, Glenn Eastwood, Anders Oldner, Rinaldo Bellomo, Johan Martensson
Summary: The study found that in adult patients admitted to an ICU in Sweden and Australia, high glycemic lability index (GLI) was associated with increased hospital mortality regardless of mean glycemia, hypoglycemia occurrence, or premorbid glycemic control.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2021)
Article
Hematology
Anna Sjostrom, Johanna Dehlsen Wersall, Anna Warnqvist, Maria Farm, Maria Magnusson, Anders Oldner, Anna Agren, Jovan Antovic, Maria Bruzelius
Summary: Elevated D-dimer levels in the first week in hospital were significantly associated with death and thrombosis in COVID-19 patients. On the other hand, an increase in platelet count was correlated with improved survival and reduced thrombotic risk. The implementation of higher doses of anticoagulation led to a decrease in D-dimer levels and an increase in platelet counts, resulting in lower mortality and thrombotic burden.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Anesthesiology
Thorir S. Sigmundsson, Tomas Ohman, Magnus Hallback, Fernando Suarez-Sipmann, Mats Wallin, Anders Oldner, Caroline Hallsjo-Sander, Hakan Bjorne
Summary: This study compared the performance of capnodynamic method with transpulmonary thermodilution in patients undergoing major abdominal surgery. The results showed that COEPBF provides acceptable continuous noninvasive CO estimation, although not interchangeable with COTPTD.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ann-Charlotte Lindstrom, Mikael Eriksson, Johan Martensson, Anders Oldner, Emma Larsson
Summary: The study found that patients with sepsis had a higher proportion of comorbidities at ICU admission, and were more likely to have low income and education level. Risk factors associated with ICU admission for sepsis patients included renal disease, liver disease, metastatic malignancy, substance abuse, and congestive heart failure. The adjusted odds ratio for 30-day mortality in sepsis patients was 132 compared to controls.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Anca Balintescu, Marcus Lind, Mikael Andersson Franko, Anders Oldner, Maria Cronhjort, Ann-Marie Svensson, Bjorn Eliasson, Johan Martensson
Summary: In individuals with type 2 diabetes, there is a U-shaped association between HbA(1c) and sepsis, with a fourfold increased risk of death among those developing sepsis.
Article
Critical Care Medicine
Alessandro Mele, Emanuele Cerminara, Henrike Habel, Borja Rodriguez-Galvez, Anders Oldner, David Nelson, Johannes Gardh, Ragnar Thobaben, Sandra Jonmarker, Maria Cronhjort, Jacob Hollenberg, Johan Martensson
Summary: This study evaluated the association between early fluid accumulation and adverse renal outcomes in septic ICU patients. The results showed that a higher cumulative fluid balance after 2 days in ICU was associated with subsequent development of major adverse kidney events within 30 days, including death, renal replacement requirement, or persistent renal dysfunction.
ANNALS OF INTENSIVE CARE
(2022)
Article
Emergency Medicine
Evelyne Zibung, Erik von Oelreich, Jesper Eriksson, Christian Buchli, Caroline Nordenvall, Anders Oldner
Summary: This study aims to assess the risk of long-term opioid use in bicycle trauma patients. The results show that severe injury to the lower extremities and low educational level are associated with an increased risk of long-term opioid use.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Critical Care Medicine
Lars Engerstrom, Johan Thermaenius, Johan Martensson, Anders Oldner, Johan Petersson, Jessica Kahlin, Emma Larsson
Summary: This study investigated the association between early prone positioning and mortality in mechanically ventilated COVID-19 patients with low oxygenation on ICU admission. The results showed no significant association between early use of prone positioning and survival. Further studies are needed to fully elucidate the effect and timing of prone position ventilation in critically ill patients with COVID-19.
Letter
Surgery
E. von Oelreich, M. Eriksson, O. Brattstrom, K-F Sjolund, A. Discacciati, E. Larsson, A. Oldner
BRITISH JOURNAL OF SURGERY
(2022)
Article
Critical Care Medicine
Jesper Eriksson, David Nelson, Anders Holst, Elisabeth Hellgren, Ola Friman, Anders Oldner
Summary: The study analyzed the temporal patterns of organ dysfunction in trauma patients admitted to the intensive care unit, identifying five distinct trajectories of organ dysfunction. Different groups showed variations in admission characteristics and subsequent trajectories of organ dysfunction, with implications for treatment strategies and outcomes.
