Article
Biotechnology & Applied Microbiology
Jieke Cui, Rong Guo, Yingjun Wang, Yue Song, Xuewen Song, Hongwen Li, Xiaoqin Song, Jiwei Li
Summary: This study identifies TOPK as a potential therapeutic target for DLBCL and demonstrates that acetylshikonin can suppress DLBCL cell growth through targeting TOPK signaling.
Article
Oncology
Jesus S. Aguilar Diaz De Leon, Honor L. Glenn, Mark Knappenberger, Chad R. Borges
Summary: The oxidation and desialylation of LDL in atherosclerotic processes significantly affect the cytotoxicity of LAK cells against K562 cells.
Article
Chemistry, Medicinal
Shuwen Han, Chunlin Zhuang, Wei Zhou, Fener Chen
Summary: Meridianin C, a natural product derived from marine organisms, and its analogues B29 and B30 showed enhanced glucose uptake and GSK-3 beta inhibitory activities, indicating therapeutic potential for diabetes.
Article
Pharmacology & Pharmacy
Zheng Xie, Xuan Wang, Xiaoxiao Luo, Jing Yan, Jie Zhang, Rao Sun, Ailin Luo, Shiyong Li
Summary: This study found that neuronal ferroptosis in the hippocampus contributes to cognitive impairment in a T2D model. Furthermore, activation of AMPK can reduce hippocampal ferroptosis and improve cognitive performance in diabetic mice.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Xiaorong Fu, Ran Zhao, Goo Yoon, Jung-Hyun Shim, Bu Young Choi, Fanxiang Yin, Beibei Xu, Kyle Vaughn Laster, Kangdong Liu, Zigang Dong, Mee-Hyun Lee
Summary: This study demonstrates that 3-deoxysappanchalcone (3-DSC) inhibits skin cancer cell growth by regulating the TOPK signaling pathway, reduces solar-simulated light-induced skin hyperplasia, and decreases tumor growth in a xenograft model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shu-qing Ma, Zhen Guo, Fang-yuan Liu, Shahzad-Gul Hasan, Dan Yang, Nan Tang, Peng An, Ming-yu Wang, Hai-ming Wu, Zheng Yang, Di Fan, Qi-zhu Tang
Summary: The study demonstrates that 6-gingerol can protect against pressure overload-induced cardiac remodeling in in vivo models by improving cardiac function and alleviating hypertrophy, fibrosis, inflammation, and dysfunction. In vitro experiments showed that 6-gingerol can block cardiomyocyte hypertrophy and cardiac fibroblast activation in response to specific stimuli.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Agriculture, Dairy & Animal Science
Fuqing Huang, Kunling Teng, Yayong Liu, Tianwei Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Nisin Z has potential anti-inflammatory effects on mastitis by inhibiting the activation of the ERK1/2 and p38 MAPK signaling pathway and promoting the blood-milk barrier.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Neha Singh, Andras Zeke, Attila Remenyi
Summary: This study reveals the presence of FBXW7-binding phosphodegrons in various important functional proteins involved in chromatin regulation and cytoskeletal regulation. The FBXW7-mediated degradation of these key regulatory proteins is diminished in the presence of different MAPKs, highlighting the importance of the MAPK and FBXW7 partnership in directly affecting the protein levels of key regulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
Yoshiaki Kamiyama, Sotaro Katagiri, Taishi Umezawa
Summary: Recent studies have shown that SnRK2s play a central role in modulating plant growth and osmotic stress signaling through various pathways, including activation mechanisms independent of ABA and regulation through TOR signaling. These findings provide important insights for further research on plant growth and stress responses.
Article
Oncology
Yu-Cheng Chang, Yi-Hao Chiang, Kate Hsu, Chih-Kuang Chuang, Chen-Wei Kao, Yi-Fang Chang, Ming-Chih Chang, Ken-Hong Lim, Hung- Cheng, Yen-Ning Hsu, Caleb G. Chen
Summary: Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL are frontline treatments for chronic myeloid leukemia (CML) and have been shown to enhance immunity. Research has revealed that gamma delta T cells expand and increase activating molecules during TKI treatments in CML patients, suggesting a positive regulatory role in TKI responses.
BLOOD CANCER JOURNAL
(2021)
Article
Multidisciplinary Sciences
Yuanjun Lu, Yazhou Liu, Junjie Lan, Yau-Tuen Chan, Zixin Feng, Lan Huang, Ning Wang, Weidong Pan, Yibin Feng
Summary: This study identified HL23 as a novel HDAC inhibitor that enhances acetylation at the TXNIP promoter to trigger TXNIP-dependent potassium deprivation and enhance the efficacy of sorafenib in HCC treatment.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Paul J. Smith, Stephanie R. McKeown, Laurence H. Patterson
Summary: The hypoxic tumour microenvironment (hTME) poses significant challenges for the treatment of solid tumours as it hampers drug delivery, promotes drug resistance, and facilitates tumour metastasis. Therapeutic strategies targeting the molecular changes associated with hypoxia and utilizing hypoxia-activated prodrugs offer potential solutions for effective treatment of tumours in the hTME.
Article
Biochemistry & Molecular Biology
Chunyang Du, Yan Zhu, Yan Yang, Lin Mu, Xue Yan, Ming Wu, Chenming Zhou, Haijiang Wu, Wei Zhang, Yanhui Wu, Guoyu Zhang, Yue Hu, Yunzhuo Ren, Yonghong Shi
Summary: CTRP3 plays a role in lipid metabolism and necroinflammation in renal tubular cells by inhibiting SREBP-1 expression, increasing PPAR-α and ABCA1 expression, and inhibiting NLRP3-mediated inflammation and MLKL-dependent necroinflammation. It also activates the AMPK pathway to provide protection.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Jia Liu, Peng Dong, Ningyi Jia, Xi Wen, Lanrong Luo, Shijun Wang, Jian Li
Summary: This study investigated the expression levels of TNF-alpha, IFN-gamma, IL-4, and IL-10 in dNK cells and found that the MAPK signal pathway is involved in the regulation of cytokine secretion by decidual NK cells at the maternal-fetal interface.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Plant Sciences
Yuzhen Mei, Yaqin Wang, Tao Hu, Zifu He, Xueping Zhou
Summary: The study reveals that the C4 protein of tomato leaf curl Yunnan virus interacts with BKI1, stabilizing it at the plasma membrane and inhibiting ER activity along with downstream MAPK cascades, thereby enhancing the chances of viral infection.