Acute lymphoblastic leukaemia patients treated with PEGasparaginase develop antibodies to PEG and the succinate linker

Efficacy and safety of recombinant E. coli asparaginase in children with previously untreated acute lymphoblastic leukemia: A randomized multicenter study of the Dutch Childhood Oncology Group

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PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

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Immunogenicity to Biotherapeutics – The Role of Anti-drug Immune Complexes

(2016) Murli Krishna et al.   Frontiers in Immunology

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

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A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia

(2014) Wing H. Tong et al.   BLOOD

Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics

(2014) Johan J.F. Verhoef et al.   DRUG DISCOVERY TODAY

Pharmacokinetic and Pharmacodynamic Properties of Calaspargase PegolEscherichia coliL-Asparaginase in the Treatment of Patients With Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Study AALL07P4

(2014) Anne L. Angiolillo et al.   JOURNAL OF CLINICAL ONCOLOGY

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

(2014) Michael S Hershfield et al.   ARTHRITIS RESEARCH & THERAPY

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Multiple routes to B-cell memory

(2012) K. L. Good-Jacobson et al.   INTERNATIONAL IMMUNOLOGY

A double antigen bridging immunogenicity ELISA for the detection of antibodies to polyethylene glycol polymers

(2011) Yijuan Liu et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

L-asparaginase treatment in acute lymphoblastic leukemia

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