Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin

Role of transporters in the disposition of a novel β-lactamase inhibitor: relebactam (MK-7655)

(2019) Grace Chan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections

(2019) Johann Motsch et al.   CLINICAL INFECTIOUS DISEASES

Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Relebactam, a β-Lactamase Inhibitor, in Combination With Imipenem and Cilastatin in Healthy Participants

(2018) Elizabeth G. Rhee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections

(2017) Matthew Sims et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Phase 2, Dose-Ranging Study of Relebactam with Imipenem-Cilastatin in Subjects with Complicated Intra-abdominal Infection

(2016) Christopher Lucasti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae

(2016) Joshua T. Thaden et al.   Virulence

Vital Signs: Preventing Antibiotic-Resistant Infections in Hospitals — United States, 2014

(2016) Lindsey M. Weiner et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City

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Increasing Incidence of Extended-Spectrum β-Lactamase-Producing Escherichia coli in Community Hospitals throughout the Southeastern United States

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Hospital Readmissions in Patients With Carbapenem-Resistant Klebsiella pneumoniae

(2015) Julia A. Messina et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

(2014) Timothy A. Blizzard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Imipenem Resistance in Pseudomonas aeruginosa Emergence, Epidemiology, and Impact on Clinical and Economic Outcomes

(2009) Ebbing Lautenbach et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Protective effect of morin on the imipenem-induced nephrotoxicity in rabbits

(2008) Sung-Chul Lim et al.   ARCHIVES OF PHARMACAL RESEARCH