Journal
BRITISH JOURNAL OF CANCER
Volume 122, Issue 6, Pages 745-748Publisher
SPRINGERNATURE
DOI: 10.1038/s41416-019-0702-4
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Funding
- National Institutes of Health (NIH), National Cancer Institute (NCI) [R03CA113157]
- National Institute of Dental and Craniofacial Research (NIDCR) [R03DE016611]
- Italian Association for Research on Cancer (AIRC)
- Italian League Against Cancer
- Italian Ministry of Research
- NCI [R01CA90731-01]
- National Institute of Environmental Health Sciences (NIEHS) [P30ES010126]
- NIH [P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667, R01CA078609, R01CA100679, R01CA048996, R01DE012609, R01CA051845]
- Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center
- Swiss League against Cancer
- Swiss Research against Cancer/Oncosuisse [KFS-700, OCS-1633]
- AIRC
- Italian Ministry of Education [PRIN 2009 X8YCBN]
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High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.
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