Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation

Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications

(2019) Sujung Choi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis

(2018) Joseph S. Burch et al.   BLOOD

Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

(2018) Shaoming Sang et al.   Alzheimers Research & Therapy

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

(2018) Kiran Kurmi et al.   Cell Reports

Mutated SUCLG1 causes mislocalization of SUCLG2 protein, morphological alterations of mitochondria and an early-onset severe neurometabolic disorder

(2018) Christos Chinopoulos et al.   MOLECULAR GENETICS AND METABOLISM

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

(2017) Lotti M. Supplie et al.   JOURNAL OF NEUROSCIENCE

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

(2017) Yugang Wang et al.   NATURE

Structural alterations induced by ten disease-causing mutations of human dihydrolipoamide dehydrogenase analyzed by hydrogen/deuterium-exchange mass spectrometry: Implications for the structural basis of E3 deficiency

(2016) Attila Ambrus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte–neuron lactate and ketone body shuttle systems

(2016) Jonathan Thevenet et al.   FASEB JOURNAL

The Human Brain Project: Creating a European Research Infrastructure to Decode the Human Brain

(2016) Katrin Amunts et al.   NEURON

Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines

(2015) Gary E. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Abnormalities in the Tricarboxylic Acid Cycle in Huntington Disease and in a Huntington Disease Mouse Model

(2015) Nima N. Naseri et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain

(2014) Arpád Dobolyi et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Human 2-Oxoglutarate Dehydrogenase Complex E1 Component Forms a Thiamin-derived Radical by Aerobic Oxidation of the Enamine Intermediate

(2014) Natalia S. Nemeria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exclusive neuronal expression of SUCLA2 in the human brain

(2013) Arpád Dobolyi et al.   Brain Structure & Function

The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation

(2013) Gergely Kiss et al.   FASEB JOURNAL

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex

(2013) Christos Chinopoulos   JOURNAL OF NEUROSCIENCE RESEARCH

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress

(2012) Anatoly A. Starkov   MOLECULAR AND CELLULAR NEUROSCIENCE

Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes

(2012) Gary E. Gibson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Role of Glutamine Synthetase and Glutamate Dehydrogenase in Cerebral Ammonia Homeostasis

(2012) Arthur J. L. Cooper   NEUROCHEMICAL RESEARCH

Allen Brain Atlas: an integrated spatio-temporal portal for exploring the central nervous system

(2012) Susan M. Sunkin et al.   NUCLEIC ACIDS RESEARCH

Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients

(2010) P. Bubber et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition

(2009) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mild reduction in the activity of the α-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis

(2009) Qingli Shi et al.   JOURNAL OF NEUROCHEMISTRY