Article
Clinical Neurology
Anthony T. Lee, Claire Faltermeier, Ramin A. Morshed, Jacob S. Young, Sofia Kakaizada, Claudia Valdivia, Anne M. Findlay, Phiroz E. Tarapore, Srikantan S. Nagarajan, Shawn L. Hervey-Jumper, Mitchel S. Berger
Summary: The removal of IES-negative HFC sites results in early transient postoperative decline in language functions, which resolved by 3 months in all patients. Measures of functional connectivity may be a useful means of counseling patients about postoperative risk.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Luca Pasquini, Mehrnaz Jenabi, Onur Yildirim, Patrick Silveira, Kyung K. Peck, Andrei I. Holodny
Summary: This study investigates the brain network modifications related to tumor grade and location using resting-state functional magnetic resonance imaging and graph theory. The results show that low-grade gliomas lead to increased efficiency of the surrounding functional network, while high-grade gliomas disrupt brain connectivity in remote areas. Tumor location also influences the pattern of network reorganization. Overall, low-grade gliomas may show more favorable network changes compared to high-grade gliomas.
Article
Oncology
Luca Pasquini, Kyung K. Peck, Alice Tao, Gino Del Ferraro, Denise D. Correa, Mehrnaz Jenabi, Erik Kobylarz, Zhigang Zhang, Cameron Brennan, Viviane Tabar, Hernan Makse, Andrei I. Holodny
Summary: This longitudinal study demonstrates the development of language plasticity in right-handed patients undergoing surgery for left-hemispheric low-grade glioma, characterized by the gradually increased involvement of the right hemisphere in language function. Two patterns of language reorganization were identified: type 1 changes may in part be treatment-related; type 2 may be tumor-induced, since atypical language organization was already present at baseline. Increased inter-hemispheric connectivity may represent the initial step in the development of plastic phenomena.
Article
Neurosciences
Nienke Wolthuis, Djaina Satoer, Wencke Veenstra, Marion Smits, Michiel Wagemakers, Arnaud Vincent, Roelien Bastiaanse, Perumpillichira J. Cherian, Ingeborg Bosma
Summary: In this study, we found that preoperative FC networks are related to pre- and postoperative language functioning in glioma patients, but to a lesser extent in meningioma patients. The presence of hubs, increased local and global FC are associated with poorer preoperative language functioning and predict worse language performance postoperatively.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Lu Jin, Chuzhong Li, Yazhuo Zhang, Taoyang Yuan, Jianyou Ying, Zhentao Zuo, Songbai Gui
Summary: This study investigated the dynamic alterations of functional connectivity within the language network in glioma patients, revealing a distinct pattern of connectivity changes modulated by tumor position. Left hemisphere gliomas had a broader impact on functional connectivity compared to right hemisphere gliomas. The findings highlight the modulatory effects of core-periphery mechanisms on language processing.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neuroimaging
Fabien Almairac, Jeremy Deverdun, Jerome Cochereau, Arthur Coget, Anne-Laure Lemaitre, Sylvie Moritz-Gasser, Hugues Duffau, Guillaume Herbet
Summary: In patients with glioma, infiltration of the insular cortex leads to significant increase in functional connectivity in the contralesional hemisphere, especially in cortical areas involved in visual and sensorimotor networks. This functional redistribution is not observed in control regions unaffected by the tumor.
NEUROIMAGE-CLINICAL
(2021)
Review
Oncology
Nardin Samuel, Artur Vetkas, Aditya Pancholi, Can Sarica, Aaron Loh, Jurgen Germann, Irene E. Harmsen, Jordy Tasserie, Vanessa Milano, Kazuaki Yamamoto, Suneil K. Kalia, Paul N. Kongkham, Andres M. Lozano
Summary: This manuscript discusses how to revolutionize and personalize pre-operative tumor evaluation and surgical planning to improve functional outcomes for brain tumor surgery. By integrating structural and functional connectivity analysis, cognitive and neurological preservation after surgery can be enhanced, and tumor spread can be attenuated. Additionally, connectivity analysis combined with neuromodulation techniques can induce post-operative neuroplasticity and personalize neurorehabilitation for patients with intra-axial tumors.
Article
Neurosciences
E. Roger, L. Rodrigues De Almeida, H. Loevenbruck, M. Perrone-Bertolott, E. Cousin, J. L. Schwartz, P. Perrier, M. Dohen, A. Vilain, P. Baraduc, S. Achard, M. Baciu
Summary: Language processing is a complex function that combines linguistic operations and non-linguistic processes, requiring a specialized neural network. Studying brain systems at rest and task-related functional connectivity provides insights into how information is processed in different cognitive states. By establishing a task-based connectivity atlas, distinct language functions and functional connectivity of brain regions can be identified.
Review
Oncology
Pushan Dasgupta, Veerakumar Balasubramanyian, John F. F. de Groot, Nazanin K. K. Majd
Summary: Preclinical models are crucial for understanding glioma biology and developing therapeutics. However, the development of ideal models is challenging due to various factors, such as genetic background, tumor heterogeneity, intact blood-brain barrier, and the tumor microenvironment. In this review, we discuss in vitro and in vivo models of glioma and the challenges involved in developing optimal models.
Article
Neurosciences
Maria E. Barnes-Davis, Hisako Fujiwara, Georgina Drury, Stephanie L. Merhar, Nehal A. Parikh, Darren S. Kadis
Summary: The study found that extreme prematurity (EPT) and history of language delay in preterm children (EPT-HLD) showed hyperconnectivity at 24-26 Hz, which may serve as a marker of advancing language development.
Article
Neurosciences
Giovanni Pellegrino, Anna-Lisa Schuler, Giorgio Arcara, Giovanni Di Pino, Francesco Piccione, Eliane Kobayashi
Summary: This study investigated the impact of EPI noise on resting state activity and connectivity using MEG. Results showed that both fMRI and white noise reduced connectivity of cortical networks, with specific effects in the auditory and sensory-motor networks for fMRI noise. Theta-delta activity related to drowsiness correlated positively with variations in cortical connectivity.
Article
Oncology
Nardin Samuel, Irene E. Harmsen, Mandy Yi Rong Ding, Can Sarica, Artur Vetkas, Christine Wong, Vanessa Lawton, Andrew Yang, Nathan C. Rowland, Suneil K. Kalia, Taufik Valiante, Richard Wennberg, Gelareh Zadeh, Paul Kongkham, Aristotelis Kalyvas, Andres M. Lozano
Summary: This study used magnetoencephalography to investigate the neurophysiologic and functional connectivity changes following glioma surgery. The findings showed distinct alterations in spectral power following tumor resection, with frequency band changes unique to each patient. Recovery of regional functional connectivity was observed in the post-operative setting, with comparable changes in low to mid gamma-associated functional connectivity noted in four patients. These findings provide a framework for future studies to examine other network changes in glioma patients and correlate neurophysiologic changes with individual patients' clinical outcomes.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Multidisciplinary Sciences
Shengyu Fang, Chunyao Zhou, Yinyan Wang, Tao Jiang
Summary: The contralesional insular lobe plays a crucial role in compensating for damaged functioning, and the patterns of network alterations observed in patients with insular DLGGs vary depending on the affected hemisphere.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Luca Pasquini, Mehrnaz Jenabi, Kyung K. Peck, Andrei I. Holodny
Summary: The relationship between functional and structural changes in patients with brain tumors remains unclear. This study found that in patients with left frontal-insular glioma, atypical language dominance was associated with increased cortical volume in the right hemisphere. Furthermore, greater cortical volume in default mode network nodes was observed in atypical language dominant patients regardless of tumor grade.
Article
Neuroimaging
Maria E. Barnes-Davis, Stephanie L. Merhar, Scott K. Holland, Nehal A. Parikh, Darren S. Kadis
Summary: This study found delays in language development among children born extremely preterm, but also noted the presence of hyperconnectivity in functional connectivity which was positively correlated with language performance.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Kshipra Gurunandan, Manuel Carreiras, Pedro M. Paz-Alonso
Summary: This study reveals the functional plasticity in language production among adult language learners, demonstrating the impact of language learning on neural correlates, and providing new insights into the verbal fluency task.
Letter
Oncology
Lucia Manso-Ortega, Garazi Bermudez, Inigo Pomposo, Santiago Gil-Robles, Maite Miranda, Manuel Carreiras, Ileana Quinones
Summary: Due to the slow growth of low-grade gliomas, cognitive impairments are difficult to detect at early stages. There is a lack of specialized staff for cognitive and emotional assessment, such as neuropsychologists and speech therapists. An accurate and individually-designed assessment of patients' cognitive status can significantly impact treatment strategies.
Article
Audiology & Speech-Language Pathology
Pavlina Heinzova, Manuel Carreiras, Simona Mancini
Summary: This study investigates the effects of argument structure on verb processing in Basque-Spanish bilinguals. The findings suggest that Basque unergatives lead to more ungrammatical sentences, while Spanish unaccusatives result in longer speech onset times.
LANGUAGE COGNITION AND NEUROSCIENCE
(2023)
Article
Audiology & Speech-Language Pathology
Yanjun Wei, Ying Niu, Marcus Taft, Manuel Carreiras
Summary: The present study investigated the effect of morphological complexity and semantic transparency on Chinese compound word recognition. Electrophysiological results from a visual lexical decision task revealed that transparent and opaque compounds elicited a stronger Left Anterior Negativity (LAN) compared to monomorphemic words. This suggests that Chinese compounds may be decomposed into constituent morphemes at the lemma level, while monomorphemic words are accessed as whole-word lemmas directly from the form level. Additionally, both behavioral experiments showed similar patterns to the EEG results. These findings provide support for morphological decomposition of compounds at the lemma level as proposed by the full-parsing model, and no evidence was found to support the role of transparency in Chinese compound word recognition.
BRAIN AND LANGUAGE
(2023)
Article
Behavioral Sciences
Lucia Amoruso, Alessandra Finisguerra, Cosimo Urgesi
Summary: Successful action comprehension requires the integration of motor information and semantic cues about objects in context. Previous evidence suggests that motor features are encoded dorsally in the fronto-parietal action observation network, while semantic features are processed ventrally in temporal structures. This study proposes an additional route to action understanding, where coarse low spatial frequency information about objects in context is projected to the dorsal action observation network via the prefrontal cortex, providing a prediction signal of the most likely intention. Experimental testing using continuous theta burst stimulation showed that stimulation over the prefrontal cortex led to spatial-frequency modulations depending on lateralization, supporting the existence of multiple routes to action comprehension in humans.
Article
Neurosciences
Anastasia Klimovich-Gray, Giovanni Di Liberto, Lucia Amoruso, Ander Barrena, Eneko Agirre, Nicola Molinaro
Summary: Early research suggested that individuals with developmental dyslexia utilize contextual information as compensation for phonological deficits, but there is currently no neuro-cognitive evidence to support this. This study used a combination of magnetoencephalography (MEG), neural encoding, and grey matter volume analyses to investigate this issue. The results showed that dyslexic readers had a deficit in speech envelope tracking, and their reading performance was related to semantic compensatory mechanisms in the right hemisphere.
Article
Behavioral Sciences
Shuang Geng, Ileana Quin, Santiago Gil-Robles, Inigo Cristobal Pomposo Gastelu, Garazi Bermudez, Polina Timofeeva, Nicola Molinaro, Manuel Carreiras, Lucia Amoruso
Summary: This study investigates the organizational principles of semantic processing in bilinguals, revealing the distinct involvement of frontoparietal regions in action knowledge retrieval. The results show increased beta oscillations in the naming of actions in Spanish and Basque after surgery, indicating language compensation. Additionally, the study highlights divergent plasticity trajectories in the first and second language after tumor resection.
Correction
Multidisciplinary Sciences
Shuang Geng, Nicola Molinaro, Polina Timofeeva, Ileana Quinones, Manuel Carreiras, Lucia Amoruso
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Polina Timofeeva, Ileana Quinones, Shuang Geng, Angela de Bruin, Manuel Carreiras, Lucia Amoruso
Summary: Bilinguals with high proficiency in both their first and second languages show similar reaction times when switching languages, supported by alpha oscillations. Behavioral experiments demonstrated a symmetric switch cost for both languages, while MEG experiments revealed symmetric neural costs in the alpha band. Brain imaging identified the involvement of right parietal and premotor areas in language selection and inhibitory control, as well as the left anterior temporal lobe in conceptually-driven lexical access.
SCIENTIFIC REPORTS
(2023)
Article
Linguistics
Clara Martin, Ileana Quinones, Manuel Carreiras
Summary: This fMRI study explored the influence of social factors on the human speech production circuit and found that social cognition is tightly linked to this circuit. Using different social contexts, such as pictures of lovers, unknown persons, or houses, the study revealed significant differences in brain activation during speech production. The socially relevant contexts evoked a widespread bilateral circuit including regions like the amygdala and anterior cingulate, while the non-socially relevant context did not. This research suggests that speech production is mediated by the social relevance of communication, similar to the avian anterior neural pathway in songbirds.
NEUROBIOLOGY OF LANGUAGE
(2023)
Article
Clinical Neurology
Franco J. Ferrante, Joaquin Migeot, Agustina Birba, Lucia Amoruso, Gonzalo Perez, Eugenia Hesse, Enzo Tagliazucchi, Claudio Estienne, Cecilia Serrano, Andrea Slachevsky, Diana Matallana, Pablo Reyes, Agustin Ibanez, Sol Fittipaldi, Cecilia Gonzalez Campo, Adolfo M. Garcia
Summary: Verbal fluency tasks are common in Alzheimer's disease assessments, but standard response counts may not reveal disease-specific semantic memory patterns. Automated word-property analysis can capture neurocognitive markers of AD and bvFTD, with specific word properties like frequency and granularity being altered only in AD. These properties can predict cognitive and neural patterns in AD, enhancing its characterization and diagnosis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Abraham Sanchez, Manuel Carreiras, Pedro M. Paz-Alonso
Summary: Processing efficiency differs between high- and low-frequency words, with less frequent words resulting in longer response latencies in several linguistic behavioral tasks. Studies using functional MRI to investigate the word frequency effect have produced heterogeneous results. This study examined the effect of word frequency through complementary analytical approaches and functional connectivity analyses. The findings suggest the involvement of the inferior frontal gyrus in semantic processing during reading, as indicated by the effect of word frequency and the influence of reading demands.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Lucia Manso-Ortega, Laura De Frutos-Sagastuy, Sandra Gisbert-Munoz, Noriko Salamon, Joe Qiao, Patricia Walshaw, Ileana Quinones, Monika M. Polczynska
Summary: Brain tumors have a significant impact on the structural organization of the brain, especially in areas related to language processing. This study examined MRI scans of patients with brain tumors in the dominant and non-dominant hemispheres for language and compared them to controls. The findings show that brain tumors induce global volumetric changes in both affected and unaffected hemispheres, which are influenced by the lateralization of the tumor. This study provides insights into the relationship between brain tumors and language processing and contributes to understanding the mechanisms of neuroplasticity after lesion occurrence.
Article
Clinical Neurology
Garazi Bermudez, Ileana Quinones, Alejandro Carrasco, Santiago Gil-Robles, Lucia Amoruso, Emmanel Mandonnet, Manuel Carreiras, Gregorio Catalan, Inigo Pomposo
Summary: Despite classical neurosurgery's assumption that many cerebral regions are non-eloquent and can be safely removed, mounting evidence suggests otherwise. The precuneus and posterior cingulate, two interconnected hubs involved in various cognitive functions, play a crucial role in reflective self-awareness, visuospatial and sensorimotor processing, and social cue processing. A case study demonstrated the success of awake craniotomy with direct electrical stimulation in achieving supramaximal resection of a low-grade glioma invading the posterior cingulum, using positive stimulation sites for line bisection and mentalizing tests to guide lesion resection. The mapping of complex functions like social cognition and self-awareness is essential for preserving patients' postoperative cognitive health and maximizing surgical resection.
ACTA NEUROCHIRURGICA
(2023)
