Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms

Current Controversy: Spikes, Bursts, and Synchrony in Generalized Absence Epilepsy: Unresolved Questions Regarding Thalamocortical Synchrony in Absence Epilepsy

(2019) John Huguenard   Epilepsy Currents

CaV 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons

(2018) Stuart M. Cain et al.   EPILEPSIA

Suppression of HCN channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures

(2018) François David et al.   JOURNAL OF NEUROSCIENCE

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

(2018) Cian McCafferty et al.   NATURE NEUROSCIENCE

Loss of HCN1 subunits causes absence epilepsy in rats

(2018) Ai Nishitani et al.   BRAIN RESEARCH

Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms

(2017) Alexandra Clemente-Perez et al.   Cell Reports

The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels

(2017) Juliane Proft et al.   Scientific Reports

Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy

(2016) V. C. Bomben et al.   JOURNAL OF NEUROSCIENCE

Lack of Intrinsic GABAergic Connections in the Thalamic Reticular Nucleus of the Mouse

(2016) G. Hou et al.   JOURNAL OF NEUROSCIENCE

Suppression of Sleep Spindle Rhythmogenesis in Mice with Deletion of CaV3.2 and CaV3.3 T-type Ca2+ Channels

(2016) Chiara Pellegrini et al.   SLEEP

Selective Maturation of Temporal Dynamics of Intracortical Excitatory Transmission at the Critical Period Onset

(2016) Qinglong Miao et al.   Cell Reports

Suppression of Sleep Spindle Rhythmogenesis in Mice with Deletion of CaV3.2 and CaV3.3 T-type Ca2+ Channels

(2016) Chiara Pellegrini et al.   SLEEP

CACNA1A haploinsufficiency causes cognitive impairment, autism and epileptic encephalopathy with mild cerebellar symptoms

(2015) Lena Damaj et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy

(2015) Guangfu Wang et al.   GENES & DEVELOPMENT

Specialization and integration of functional thalamocortical connectivity in the human infant

(2015) Hilary Toulmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low- and high-frequency oscillations reveal distinct absence seizure networks

(2014) Jeffrey R. Tenney et al.   ANNALS OF NEUROLOGY

Neuronal Plasticity: Beyond the Critical Period

(2014) Mark Hübener et al.   CELL

Developmental changes in Ca2+channel subtypes regulating endocytosis at the calyx of Held

(2014) Mitsuharu Midorikawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cell Types, Network Homeostasis, and Pathological Compensation from a Biologically Plausible Ion Channel Expression Model

(2014) Timothy O’Leary et al.   NEURON

Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy

(2014) Stuart M. Cain et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice

(2014) S. E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development

(2013) Masanobu Kano et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: Initial monotherapy outcomes at 12 months

(2012) Tracy A. Glauser et al.   EPILEPSIA

Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations

(2011) M. D. Mark et al.   JOURNAL OF NEUROSCIENCE

Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

(2011) Zhuo Huang et al.   NATURE NEUROSCIENCE

Genetic and functional characterisation of the P/Q calcium channel in episodic ataxia with epilepsy

(2010) Sanjeev Rajakulendran et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fine-tuning of pre-balanced excitation and inhibition during auditory cortical development

(2010) Yujiao J. Sun et al.   NATURE

Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy

(2010) Tracy A. Glauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis

(2009) Z. Huang et al.   JOURNAL OF NEUROSCIENCE

Genetic Enhancement of Thalamocortical Network Activity by Elevating  1G-Mediated Low-Voltage-Activated Calcium Current Induces Pure Absence Epilepsy

(2009) W. L. Ernst et al.   JOURNAL OF NEUROSCIENCE

Deletion of phospholipase C  4 in thalamocortical relay nucleus leads to absence seizures

(2009) E. Cheong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of T-type Ca2+channels in the potentiation of synaptic and visual responses during the critical period in rat visual cortex

(2008) Yumiko Yoshimura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+Channel Antagonist

(2008) William D. Shipe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Correlation of T-channel coding gene expression, IT, and the low threshold Ca2+ spike in the thalamus of a rat model of absence epilepsy

(2008) Tilman Broicher et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2

(2008) Wendy K. Chung et al.   NEUROBIOLOGY OF DISEASE