Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Stephanie Alimena, Lauren Philp, Endel John Orav, Mackenzie W. Sullivan, Marcela Del Carmen, Annekathryn Goodman, Whitfield B. Growdon, Amy Bregar, Eric Eisenhauer, Rachel Clark Sisodia
Summary: While no obvious memory issues were discovered with serial administration of patient-reported outcome measures, rates of adverse emotional symptoms such as depression, tension, and worry decreased after chemotherapy. Chemotherapy can have some impact on patients' social lives. Further research with a larger cohort is needed to explore the phenomenon of chemotherapy-related cognitive impairment.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Gastroenterology & Hepatology
John E. Pandolfino, Dustin A. Carlson, Josie McGarva, Peter J. Kahrilas, Michael Vaezi, David Katzka, Tiffany H. Taft
Summary: The study developed a new Achalasia Patient-Reported Outcomes (APRO) Questionnaire, identified three subscales through investigation of patients with normal motility and achalasia, and found that symptom anxiety and hypervigilance moderate the relationship between APRO and quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Adrienne H. Kovacs, Gerald Lebovic, Stavroula Raptis, Samuel Blais, Christopher A. Caldarone, Nagib Dahdah, Frederic Dallaire, Christian Drolet, Jasmine Grewal, Camille L. Hancock Friesen, Edward Hickey, Gauri Rani Karur, Paul Khairy, Benedetta Leonardi, Michelle Keir, Brian W. McCrindle, Syed Najaf Nadeem, Ming-Yen Ng, Ashish H. Shah, Edythe B. Tham, Judith Therrien, Andrew E. Warren, Isabelle F. Vonder Muhll, Alexander Van de Bruaene, Kenichiro Yamamura, Michael E. Farkouh, Rachel M. Wald
Summary: This study explored the relationship between pulmonary regurgitation and quality of life and health status in adults with Tetralogy of Fallot (TOF), and found that with advancing age, patients reported more problems in mobility and pain or discomfort. Factors associated with superior patient-reported outcomes include race, syndrome, employment, and left ventricular function, while being asymptomatic was found to have the greatest impact on quality of life and health status.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Luc Biedermann, Marla C. Dubinsky, Severine Vermeire, Marc Fellmann, Sean Gardiner, Peter Hur, Rajiv Mundayat, Julian Panes, David T. Rubin
Summary: Long-term treatment with tofacitinib in patients with ulcerative colitis showed sustained favorable impact on health-related quality of life (HRQoL), regardless of baseline remission status or treatment history.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Bram Verstockt, Lieven Pouillon, Florence Ballaux, Celine Jorissen, Eveline Hoefkens, Nikki Lembrechts, Peter Bossuyt
Summary: Treating beyond endoscopic remission, aiming for histological remission, is an emerging target in UC. Patient-reported outcome measurements (PROMs) become increasingly important, but their association with histology is unclear.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Oncology
Myung-Kyung Lee, Jihyun Oh
Summary: Exercise can have a synergistic effect on improving health-related quality of life (HRQOL) and depression in patients with gastric cancer, by indirectly positively affecting depression and directly influencing HRQOL.
Article
Cardiac & Cardiovascular Systems
Onkar Khullar, Aubriana Perez, Meredith Dixon, Jose N. Binongo, Manu S. Sancheti, Allan Pickens, Theresa Gillespie, Seth D. Force, Felix G. Fernandez
Summary: This study examined the success of routine patient-reported outcomes (PROs) assessment in an academic-based thoracic surgery practice. Results showed that out of 9725 thoracic surgery office visits, PROs data were obtained in 6899 visits from 3551 patients. The overall questionnaire completion rate was 65.7%, with a significant decline in April 2020. Rating: 8 out of 10.
ANNALS OF THORACIC SURGERY
(2023)
Article
Oncology
Emily E. van Seventer, Madeleine G. Fish, Kathryn Fosbenner, Katie Kanter, Amirkasra Mojtahed, Jill N. Allen, Lawrence Blaszkowsky, Jeffrey W. Clark, Jon Dubois, Joseph W. Franses, Bruce J. Giantonio, Lipika Goyal, Samuel J. Klempner, Eric J. Roeland, David P. Ryan, Colin D. Weekes, Therese Mulvey, Areej El-Jawahri, Nora Horick, Ryan B. Corcoran, Aparna R. Parikh, Ryan D. Nipp
Summary: This study found that baseline patient-reported outcomes (PROs) are associated with treatment response, healthcare utilization, and survival in patients with advanced gastrointestinal cancer. Specifically, physical symptoms and functional quality of life were correlated with disease progression and survival.
Review
Dentistry, Oral Surgery & Medicine
Gotfredsen Klaus
Summary: Evidence-based dentistry involves using evidence from the literature, clinical expertise, and patient expectations to make decisions and assess treatment. Patient satisfaction can be evaluated using questionnaires or structured questions and includes affability, availability, and ability. Questionnaires such as the oral health impact profile (OHIP) or the dental impact on daily living (DIDL) can be used to assess patient perception and quality of life. Patient-reported outcome measures (PROMs) have shown to enhance patient engagement and should be integrated into clinical care.
PERIODONTOLOGY 2000
(2023)
Article
Surgery
S. R. Markar, V Sounderajah, A. Johar, G. Zaninotto, C. Castoro, P. Lagergren, J. A. Elliott, S. S. Gisbertz, C. Mariette, R. Alfieri, J. Huddy, E. Pinto, M. Scarpa, F. Klevebro, B. Sunde, C. F. Murphy, C. Greene, N. Ravi, G. Piessen, H. Brenkman, J. Ruurda, R. van Hillegersberg, S. M. Lagarde, B. P. Wijnhoven, M. Pera, J. Roigg, S. Castro, R. Matthijsen, J. Findlay, S. Antonowicz, N. Maynard, O. McCormack, A. Ariyarathenam, G. Sanders, E. Cheong, S. Jaunoo, W. Allum, J. van Lanschot, M. Nilsson, J. Reynolds, M. I. van Berge Henegouwen, G. B. Hanna
Summary: Long-term symptom burden is common after oesophageal cancer surgery, with symptoms clustering into six domains: lethargy, musculoskeletal pain, dumping, lower gastrointestinal symptoms, regurgitation/reflux, and swallowing problems. Factors associated with severe symptoms include surgical approach, neoadjuvant therapy, patient age, and sex.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Dermatology
Yael Renert-Yuval, Joel Correa da Rosa, Sandra Garcet, Ana B. Pavel, Jennifer Bares, Margot Chima, Jason E. Hawkes, Patricia Gilleaudeau, Mary Sullivan-Whalen, Giselle K. Singer, James G. Krueger, Emma Guttman-Yassky
Summary: This study investigated the utility of two different alopecia areata-targeted questionnaires, and found that the Alopecia Areata Symptom Impact Scale (AASIS) correlated strongly with alopecia areata severity and clinical response. Patients with <= 20% scalp hair loss after treatment reported improvement in multiple quality-of-life items, which may guide clinicians and improve the development of future clinical trials.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Katsuyoshi Matsuoka, Katsumasa Nagano, Shinya Nagasaki, Yoko Murata, Tadakazu Hisamatsu
Summary: This study aims to investigate the relationship between treatment response and early response indicators in UC patients receiving ustekinumab induction therapy, as well as patient factors that may define the appropriate dosing interval for maintenance therapy.
Article
Health Care Sciences & Services
Arpita Nag, Beverly Romero
Summary: This study aimed to develop and validate two patient-reported outcome (PRO) tools to assess signs and symptoms in patients with moderate-to-severe UC or CD. The tools were developed and refined based on concept elicitation and cognitive interviews, and in accordance with FDA recommendations.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Oncology
Victoria Huynh, Kathryn Colborn, Shelby Smith, Levi N. Bonnell, Gretchen Ahrendt, Nicole Christian, Simon Kim, Dan D. Matlock, Clara Lee, Sarah E. Tevis
Summary: This study aimed to compare longitudinal patient-reported outcomes between breast cancer patients undergoing lumpectomy and mastectomy, finding that mastectomy patients experienced significantly greater decreases in breast satisfaction, psychosocial well-being, and sexual well-being over time compared with lumpectomy patients, with lumpectomy patients more likely to return to baseline scores at 3 and 6 months postoperatively. Understanding these differences can inform early intervention strategies to prevent long-term morbidities.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Antonio Tursi, Giammarco Mocci, Leonardo Allegretta, Giovanni Aragona, Maria Antonia Bianco, Raffaele Colucci, Antonio Cuomo, Nicola Della Valle, Antonio Ferronato, Giacomo Forti, Federica Gaiani, GianMarco Giorgetti, Maria Giovanna Graziani, Katia Lofano, Roberto Lorenzetti, Tiziana Larussa, Antonio Penna, Roberta Pica, Giuseppe Pranzo, Stefano Rodino', Antonella Scarcelli, Costantino Zampaletta, Gabrio Bassotti, Alessia Immacolata Cazzato, Stefania Chiri, Valeria Clemente, Andrea Cocco, Gianluigi de' Angelis, Laura Donnarumma, Roberto Faggiani, Camilla Graziosi, Marco Le Grazie, Francesco Luzza, Costantino Meucci, Rita Monterubbianesi, Cristiano Pagnini, Patrizia Perazzo, Marcello Picchio, Rodolfo Sacco, Ladislava Sebkova, Mariaelena Serio, Daniele Napolitano, Daniela Pugliese, Franco Scaldaferri, Elisa Schiavoni, Laura Turchini, Alessandro Armuzzi, Walter Elisei, Giovanni Maconi, Alfredo Papa
Summary: There is no significant difference in the efficacy and safety of different ADA biosimilars in the treatment of inflammatory bowel disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Edward V. Loftus, Daniel C. Baumgart, Krisztina Gecse, Jami A. Kinnucan, Susan B. Connelly, Leonardo Salese, Chinyu Su, Kenneth K. Kwok, John C. Woolcott, Alessandro Armuzzi
Summary: CDIs in patients with UC receiving tofacitinib were infrequent, with mild-moderate severity, and most cases resolved with treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Cristina Bezzio, Gionata Fiorino, Davide G. Ribaldone, Alessandro Armuzzi, Simone Saibeni
Summary: This study investigated the impact of severe acute respiratory syndrome coronavirus 2 infection on inflammatory bowel disease course and found that therapy discontinuation is a risk factor for disease flare.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Konstantinos H. Katsanos, Fotios S. Fousekis, Alessandro Armuzzi
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Roberta Vitali, Francesca Palone, Alessandro Armuzzi, Valerio Fulci, Anna Negroni, Claudia Carissimi, Salvatore Cucchiara, Laura Stronati
Summary: This study identified three novel faecal biomarkers of gut inflammation using proteomic analysis in patients with inflammatory bowel disease. These biomarkers have good specificity and sensitivity for identifying the disease and significantly correlate with disease severity.
JOURNAL OF CROHNS & COLITIS
(2023)
Correction
Gastroenterology & Hepatology
A. Caputo, P. Parente, M. Cadei, M. Fassan, A. Rispo, G. Leoncini, G. Bassotti, R. Del Sordo, C. Metelli, M. Daperno, A. Armuzzi, V. Villanacci
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Olga Maria Nardone, Alessandro Armuzzi
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Nutrition & Dietetics
Giulia Rizzo, Samuel Elias Pineda Chavez, Elisa Vandenkoornhuyse, Cindy Lorena Cardenas Rincon, Valeria Cento, Valentina Garlatti, Marek Wozny, Giusy Sammarco, Alessia Di Claudio, Lisa Meanti, Sudharshan Elangovan, Andrea Romano, Giulia Roda, Laura Loy, Arianna Dal Buono, Roberto Gabbiadini, Sara Lovisa, Roberto Rusconi, Alessandro Repici, Alessandro Armuzzi, Stefania Vetrano
Summary: This study found that pomegranate extract has beneficial effects in promoting the recovery phase of colitis and the complete restoration of the intestinal barrier. It also affects pathogen biofilm formation and promotes mucosal regeneration through the regulation of the crosstalk between epithelial and stromal cells.
Review
Medicine, General & Internal
Virginia Solitano, Arianna Dal Buono, Roberto Gabbiadini, Marek Wozny, Alessandro Repici, Antonino Spinelli, Stefania Vetrano, Alessandro Armuzzi
Summary: Fibro-stenosing Crohn's disease (CD) is a common disease presentation that leads to impaired quality of life and often requires endoscopic treatments or surgery. Currently, there are no existing imaging techniques that can accurately quantify the amount of fibrosis within a stricture, and managing patients is challenging, requiring a multidisciplinary team.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ahmad Albshesh, Lian Bannon, Tali Sharar Fischler, Marie Truyens, Stephan R. R. Vavricka, Katja Tepes, Daniela Pugliese, Edoardo V. V. Savarino, Eran Zittan, David Drobne, Xavier Roblin, Ariella Bar-Gil Shitrit, Alessandro Armuzzi, Triana Lobaton, Nitsan Maharshak, Henit Yanai, Shomron Ben-Horin, Uri Kopylov
Summary: The effectiveness of anti-TNF or ustekinumab as a second-line biologic after vedolizumab failure in patients with Crohn's disease was investigated. The results showed that there was no significant difference in the clinical response, remission rate, and discontinuation rate between the use of anti-TNF and ustekinumab as a second-line therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Gastroenterology & Hepatology
Arianna Dal Buono, Alessandro Armuzzi
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Tamas Resal, Peter Bacsur, Csilla Keresztes, Anita Balint, Renata Bor, Anna Fabian, Bernadett Farkas, Kostas Katsanos, George Michalopoylos, Davide Giuseppe Ribaldone, Mohamed Attauabi, Mirabella Zhao, Hadar Amir Barak, Henit Yanai, Cristina Bezzio, Antonio Rispo, Fabiana Castiglione, Ariella Bar-Gil Shitrit, Daniela Pugliese, Alessandro Armuzzi, Edoardo Vincenzo Savarino, Martin Kolar, Milan Lukas, Elena Chashkova, Rafal Filip, Aurore Rozieres, Stephane Nancey, Zeljko Krznaric, Eszter Schafer, Patricia Szamosi, Patricia Sarlos, Matej Franko, David Drobne, Oleg Knyazev, Anna Kagramanova, Jimmy Limdi, Panu Wetwittayakhlang, Peter L. Lakatos, Nitsan Maharshak, Lian Bannon, Tibor Nyari, Zoltan Szepes, Klaudia Farkas, TFB Study Grp, Tamas Molnar
Summary: Background and Aims: This retrospective, international cohort study aimed to evaluate the efficacy and safety of tofacitinib (TFB) in the treatment of moderate-to-severe colitis and acute severe ulcerative colitis (ASUC). The study found that TFB was effective in both indications and resulted in high rates of steroid-free remission in the short and long terms.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Maria Terrin, Giulia Migliorisi, Arianna Dal Buono, Roberto Gabbiadini, Elisabetta Mastrorocco, Alessandro Quadarella, Alessandro Repici, Armando Santoro, Alessandro Armuzzi
Summary: The introduction of immunotherapy, particularly immune checkpoint inhibitors (ICIs), has significantly changed the therapeutic algorithms for solid tumors. ICIs can lead to immune-related adverse events, with the gastrointestinal tract being commonly affected by varying levels of mucosal inflammation. The pathogenesis of checkpoint inhibitors colitis (CIC) is multifactorial and not fully understood, involving both anti-tumor activity and upregulation of specific inflammatory pathways. Treatment options for CIC, including biological therapy such as anti-TNF alpha, need to be further explored and prompt recognition and treatment are crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Carolina Aliai Micol Cavalli, Roberto Gabbiadini, Arianna Dal Buono, Alessandro Quadarella, Alessandro De Marco, Alessandro Repici, Cristina Bezzio, Edoardo Simonetta, Stefano Aliberti, Alessandro Armuzzi
Summary: Inflammatory bowel diseases (IBDs) are associated with respiratory diseases, even in the absence of symptoms. The same embryological origin and exposure to common antigens and cytokine networks may play a role in respiratory involvement. Early identification and treatment of respiratory manifestations are crucial to prevent lung damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Bianca Bartocci, Arianna Dal Buono, Roberto Gabbiadini, Anita Busacca, Alessandro Quadarella, Alessandro Repici, Emanuela Mencaglia, Linda Gasparini, Alessandro Armuzzi
Summary: Inflammatory bowel diseases (IBD) have been shown to be associated with a high prevalence of psychiatric comorbidities, particularly anxiety and depression. Studies have suggested that the prevalence of mental disorders is higher in IBD patients with active intestinal disease. However, these comorbidities are often under-diagnosed and require more attention in the management of IBD patients.
MEDICINA-LITHUANIA
(2023)