Article
Obstetrics & Gynecology
L. A. W. Jansen, M. H. Koot, J. van't Hooft, C. R. Dean, P. M. M. Bossuyt, W. Ganzevoort, N. Gauw, B. Y. van der Goes, J. Rodenburg, T. J. Roseboom, R. C. Painter, I. J. Grooten
Summary: Through a mixed-methods approach, a consensus definition for hyperemesis gravidarum was developed through a Delphi survey, a consensus development meeting and consultation. Stakeholders from diverse international backgrounds contributed to forming a unified understanding of hyperemesis gravidarum, aiming to enhance consistency in clinical studies and improve the value of evidence for patient care.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Medicine, General & Internal
Hongjiang Zhao, Linzhen Wu, Bin Yang, Hongkai Shang
Summary: Midgut malrotation is a rare congenital abnormality that can present as hyperemesis gravidarum during pregnancy. Close monitoring and conservative treatment are recommended after diagnosis.
Article
Nutrition & Dietetics
Kate Maslin, Hazel A. Billson, Caitlin R. Dean, Julie Abayomi
Summary: This study explored the role of Registered Dietitians in managing Hyperemesis Gravidarum in the UK. Findings revealed inconsistent use of referral criteria and a lack of specific clinical guidelines, suggesting the need for further training, early recognition of malnutrition, and increased investment in dietitians to enhance nutritional care for HG patients.
Review
Obstetrics & Gynecology
Pinelopi Varela, Anna Deltsidou
Summary: The study aimed to systematically review evidence on the relationship between HG and neonatal outcomes, finding moderate quality studies and concluding that it's still uncertain whether HG has an adverse impact on neonatal outcomes, requiring further research.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Review
Nutrition & Dietetics
Kate Maslin, Caitlin Dean
Summary: Hyperemesis gravidarum (HG) is a severe condition affecting pregnant women, leading to malnutrition and other complications that can have negative impacts on maternal and fetal health. Limited research exists on dietary interventions, and effective treatment requires a multidisciplinary approach.
NUTRITION RESEARCH REVIEWS
(2022)
Article
Obstetrics & Gynecology
Burcu Timur, Gurhan Guney
Summary: This study investigates the levels of ADAMTS-1 and its correlation with ketonuria in patients with hyperemesis gravidarum. The results show that ADAMTS-1 serum levels are increased in hyperemesis gravidarum patients and positively correlated with ketonuria.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Obstetrics & Gynecology
Kate Maslin, Victoria Shaw, Anne Brown, Caitlin Dean, Jill Shawe
Summary: Women with Hyperemesis gravidarum (HG) have significantly poorer dietary intake compared to non-affected pregnant women, consuming less than 50% of recommended intakes for most nutrients. Nutritional intake worsens with increasing severity of symptoms, indicating a risk of malnutrition in women with HG. Future research quantifying nutritional intake in women with HG at different time points during pregnancy is needed to monitor nutritional status and evaluate interventions.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Miina Nurmi, Paivi Rautava, Mika Gissler, Tero Vahlberg, Paivi Polo-Kantola
Summary: This study evaluated the burden of illness caused by hyperemesis gravidarum (HG) and its association with readmissions. The majority of women with HG required repeated medical care and factors such as multiple gestation, high parity, and female fetus were associated with higher odds of readmission. On the other hand, factors like maternal age, pre-pregnancy BMI, smoking, and assisted reproductive technology were related to lower odds of readmission.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Nutrition & Dietetics
Kiwamu Noshiro, Takeshi Umazume, Rifumi Hattori, Soromon Kataoka, Takashi Yamada, Hidemichi Watari
Summary: This study found that serum ketone levels peak in the third trimester of pregnancy, but do not directly correlate with neonatal body shape. Weight loss during pregnancy may be related to morning sickness, with a higher pre-pregnancy body mass index leading to greater weight loss.
Review
Obstetrics & Gynecology
Tilda Moberg, Lennart van der Veeken, Emma Persad, Stefan R. Hansson, Matteo Bruschettini
Summary: This systematic review aimed to investigate the potential correlation between nausea and vomiting in pregnancy (NVP) or hyperemesis gravidarum (HG) with adverse pregnancy outcomes and human chorionic gonadotropin (hCG) levels. The evidence suggests that women with HG may have an increased risk for preeclampsia, preterm delivery, small for gestational age, low birth weight, and a higher fetal female/male ratio. On the other hand, women with NVP may have a lower risk for preterm delivery and low birth weight, but a higher risk for small for gestational age and a higher fetal female/male ratio. However, the evidence for these conclusions is very uncertain.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, Research & Experimental
Stefan L. Popa, Maria Barsan, Alexandra Caziuc, Cristina Pop, Lucian Muresan, Luminita Celia Popa, Lacramioara Perju-Dumbrava
Summary: Hyperemesis gravidarum (HG) can lead to severe complications with a risk of fatality, but there is limited research on this topic.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
O. Kocak, E. Tahir
Summary: Compared to healthy pregnant women, hyperemesis gravidarum negatively affects voice quality and increases gastrointestinal complaints, as shown in this study using subjective parameters. Further studies are needed to make an objective evaluation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
M. B. Divya, N. S. Kubera, Nivedita Jha, Ajay Kumar Jha, Molly Mary Thabah
Summary: Hyperemesis gravidarum can lead to neurological abnormalities that can be treated with parenteral thiamine. Some patients may exhibit atypical symptoms and MRI scans may show abnormalities suggestive of Wernicke encephalopathy.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Chuan Wang, Xing Hu, Ka U. U. Lio, Jianhua Lin, Ning Zhang
Summary: Cerebral venous thrombosis (CVT) in early pregnancy is rare and presents with a wide range of clinical manifestations, often overlapping with symptoms of nausea and vomiting of pregnancy/hyperemesis gravidarum (NVP/HG), making diagnosis challenging. MRI/MRV is crucial for diagnosis, and early anticoagulation is essential for prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Aylin Saglam, Iris Derwig, Mekin Sezik, Sibel Cigdem Tuncer, Mustafa D. Ozcil, Burcu Kasap, Mesut Misirlioglu, Ender Alkan, Namik Ozkan
Summary: This study found an association between biliary sludge (BS) formation and hyperemesis gravidarum (HG) in pregnant women. HG may lead to new sludge formation and severe complications. BS may also independently increase the risk of subsequent preterm delivery.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Anadeijda J. E. M. C. Landman, Emilie V. J. van Limburg Stirum, Janneke van 't Hooft, Aleid G. Leemhuis, Martijn J. J. Finken, Anneloes L. van Baar, Tessa J. Roseboom, Anita C. J. Ravelli, Madelon van Wely, Jaap Oosterlaan, Rebecca C. Painter, Eva Pajkrt, Martijn A. Oudijk, Marjon A. de Boer
Summary: This follow-up study aims to assess the long-term effects of antenatal exposure to low-dose aspirin compared with placebo on survival, (neuro)development, behaviour and general health at 4 years corrected age.
Article
Acoustics
R. J. Burger, S. J. Gordijn, B. W. Mol, W. Ganzevoort, A. C. J. Ravelli
Summary: The study aimed to assess the association between birth-weight centile and intellectual development in term/near-term infants across the entire birth-weight spectrum. The results showed a positive association between birth-weight centile and school performance at the age of 12, highlighting the importance of developing better tools for diagnosing fetal growth restriction and reduced placental function, as well as identifying risks for associated short- and long-term consequences.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Renee J. Burger, Ben W. W. Mol, Wessel Ganzevoort, Sanne J. J. Gordijn, Eva Pajkrt, Joris A. M. Van Der Post, Christianne J. M. De Groot, Anita C. J. Ravelli
Summary: This study examined the impact of labor induction at each week of gestation from 37 to 42 weeks on offspring's school performance at age 12. The results showed that induction of labor was associated with decreased school performance scores and a lower proportion of children reaching higher secondary school level. These long-term effects should be taken into account in counseling and decision making.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Letter
Obstetrics & Gynecology
Renee J. Burger, Anita C. J. Ravelli, Sanne J. Gordijn, Wessel Ganzevoort
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Obstetrics & Gynecology
Larissa A. W. Jansen, Kelly Nijsten, Jacqueline Limpens, Rik van Eekelen, Marjette H. Koot, Iris J. Grooten, Tessa J. Roseboom, Rebecca C. Painter
Summary: This study evaluated the effect of hyperemesis gravidarum on perinatal outcomes and found that it was associated with adverse outcomes such as low birth weight and preterm birth. It also observed that pregnancies complicated by hyperemesis gravidarum were less likely to have macrosomia and stillbirth. However, the underlying mechanisms could not be investigated.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Renee J. Burger, Tessa J. Roseboom, Wessel Ganzevoort, Sanne J. Gordijn, Eva Pajkrt, Ameen Abu-Hanna, Martine Eskes, Aleid G. Leemhuis, Ben W. Mol, Christianne J. M. de Groot, Anita C. J. Ravelli
Summary: This study investigates the association between gestational age, sociodemographic characteristics, and school performance at the age of 12. Results show that longer gestational age is associated with better school performance, regardless of socio-demographic factors. Factors such as maternal education, maternal age, and ethnicity also influence school performance. Preterm children and those from socially or economically disadvantaged backgrounds are more vulnerable to the negative impact of preterm birth on school performance. Caution is needed in interpreting the results due to differential loss to follow-up.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Developmental Biology
T. Yee Khong, Sanne J. Gordijn, Mirthe H. Schoots, Wessel Ganzevoort, Katie M. Groom, Suzette Coat, William M. Hague
Summary: The addition of placental histopathology studies to obstetric trials can be cost-effective and provide insights into functional dysfunctions. We share our experience of adding placental pathological examination to two clinical trials, one retrospectively and one at the outset, to help other investigators. The practical issues involved are regulatory and ethical considerations, operational challenges, and proper reporting. Prospective inclusion of placental pathological examination in clinical trial protocols is easier with sufficient funding.
Article
Multidisciplinary Sciences
Stefanie Elisabeth Damhuis, Hester Dorien Kamphof, Anita C. J. Ravelli, Sanne Jehanne Gordijn, Wessel J. Ganzevoort
Summary: This study aimed to evaluate the burden of hypoxia-related adverse perinatal outcomes among (near) term births, reflected in an association with birth weight centiles as a proxy for placental function. The study found that the incidence of hypoxia-related outcomes was highest in fetuses with lowest birth weight centiles but can be identified throughout the entire spectrum. Additional diagnostic modalities that indicate placental dysfunction at (near) term gestation are urgently needed.
Review
Psychiatry
Aline Marileen Wiegersma, Amber Boots, Miranda w W. Langendam, Jacqueline Limpens, Susan D. D. Shenkin, Aniko Korosi, Tessa J. J. Roseboom, Susanne R. de Rooij
Summary: This systematic review examined the association between prenatal factors and later risk for dementia, finding that prenatal factors related to a suboptimal prenatal environment are associated with an increased risk of dementia.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Kayleigh D. Gultig, Susanne R. de Rooij, Charlotte E. Hilberdink, Miranda Olff, Tessa J. Roseboom, Mirjam van Zuiden
Summary: This study investigated whether genetic variations in the glucocorticoid receptor (GR) modulate the effects of prenatal famine exposure on PTSD symptom severity in late adulthood. The results showed that individuals exposed to famine during early gestation without the GR Bcll haplotype had a stronger association between adulthood trauma and PTSD symptom severity, indicating increased susceptibility to PTSD. These findings highlight the importance of considering genetics and environmental contexts throughout life, including the prenatal environment.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Rene Prime E. J. Burger, Tessa J. Roseboom, Eva Pajkrt, Ameen Abu-Hanna, Martine Eskes, Aleid G. Leemhuis, Ben W. Mol, Wessel Ganzevoort, Sanne J. Gordijn, Christianne de Groot, Anita C. Ravelli
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Renee J. Burger, Eva Pajkrt, Ben W. Mol, Wessel Ganzevoort, Sanne J. Gordijn, Joris van der Post, Christianne de Groot, Anita C. Ravelli
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Stefanie E. Damhuis, Henk Groen, Basky Thilaganathan, Wessel Ganzevoort, Sanne J. Gordijn
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Marjon Feenstra, Mirthe Schoots, Jelmer Prins, Harry van Goor, Wessel Ganzevoort, Sanne J. Gordijn
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
