Article
Biochemistry & Molecular Biology
Ji-In Ryu, Byoung-Eun Yang, Sang-Min Yi, Hyo-Geun Choi, Sung-Woon On, Seok-Jin Hong, Ho-Kyung Lim, Soo-Hwan Byun
Summary: The study demonstrated that 3D-printed custom HA/TCP graft with rhBMP-2 showed bone regeneration effects similar to that of particulate Bio-Oss with rhBMP-2, suggesting its potential application in various fields of bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Veterinary Sciences
Daniel Cardoso Garcia, Larissa Eckmann Mingrone, Marcelo Jorge Cavalcanti De Sa
Summary: This study summarized the clinical and experimental studies using β-TCP as a bone substitute, showing promising results in bone integration with predictable, sustainable and adequate new bone formation. However, there is a lack of information on its application in veterinary medicine, and more research is needed to evaluate its osseoconductive and osseointegrative characteristics in animals.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Materials Science, Ceramics
Wu Wei, Shahd Bakhet, Naomi Addai Asante, Shefiu Kareem, Omar Ramadhan Kombo, Li Binbin, Dai Honglian
Summary: Beta tricalcium phosphate (ss-TCP) ceramic substituted materials have attracted attention due to their similarity with bone inorganic components and good biocompatibility. In this study, different microsphere materials of tricalcium phosphate/trimagnesium phosphate composites were prepared and evaluated for their degradation rate, biocompatibility, angiogenesis, and osteogenesis. The results showed that microspheres with 25% TMP and 50% TMP had better cell compatibility and promoted angiogenesis and osteogenesis.
JOURNAL OF INORGANIC MATERIALS
(2023)
Article
Polymer Science
Kseniya Stepanova, Daria Lytkina, Rustam Sadykov, Kseniya Shalygina, Toir Khojazoda, Rashidjon Mahmadbegov, Irina Kurzina
Summary: The primary purpose of this study was to develop a composite cement material for bone regeneration. The authors obtained β-tricalcium phosphate powder through a liquid-phase method and achieved the solidification and hardening of the cement system by adding calcium sulfate hemihydrate. Polymer components such as polyvinyl alcohol and polyvinylpyrrolidone were used, and their miscibility was determined by intermolecular hydrogen bonds. The solubility of the composite materials was influenced by the solubility of calcium sulfate dihydrate, and the viability of human macrophages in the presence of the samples varied from 80% to 125% compared to the control.
Article
Cell Biology
Rayan Fairag, Li Li, Jose Luis Ramirez-GarciaLuna, M. Scott Taylor, Brian Gaerke, Michael H. Weber, Derek H. Rosenzweig, Lisbet Haglund
Summary: The study found that 100M and 7415 scaffolds with added beta-tricalcium phosphate can significantly enhance mesenchymal stem cells differentiation and mineralized matrix deposition in vitro. In a rat femur window defect model, 100M(+beta-TCP) implants showed positive biosafety profile and enhanced new bone formation compared to 100M implants, indicating great potential for clinical translation. Further evaluation in larger animal models with long-term follow-up is needed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Berna Kankilic, Erdal Bayramli, Petek Korkusuz, Hakan Eroglu, Burcin Sener, Pelin Mutlu, Feza Korkusuz
Summary: This study developed vancomycin-containing PDLLA/β-TCP and PLGA/β-TCP composites that can inhibit early biofilm formation and promote cell proliferation and osteogenic differentiation in the absence of an osteogenic medium. However, the expression of osteogenesis-related transcription factors RUNX2 and SOX9 was not strongly expressed within 14 days.
FRONTIERS IN SURGERY
(2022)
Article
Polymer Science
Beiyuan Gao, Yoshitomo Honda, Yoichi Yamada, Tomonari Tanaka, Yoshihiro Takeda, Takayuki Nambu, Shunsuke Baba
Summary: The newly developed material vhEc-GS-beta showed high stability and bone-forming ability in experiments, achieved through thermal cross-linking induced in gelatin sponges by vacuum heating treatment. This insight could potentially lead to the development of novel materials with good operability and bone-forming ability in bone regenerative medicine.
Article
Materials Science, Composites
Trimeche Monia, Ben Cheikh Ridha, Keskes Hassib
Summary: Researchers developed a bioresorbable synthetic bone substitute (beta-TCP/DCPD)-PHBV and evaluated its ability to trigger bone regeneration through bone implant experiments on 12 New Zealand white male rabbits.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2023)
Article
Orthopedics
Junichi Sumii, Tomoyuki Nakasa, Yuichi Kato, Shigeru Miyaki, Nobuo Adachi
Summary: Microfracture (MF) is a commonly used treatment for articular cartilage defects, but it may lead to poor clinical outcomes due to subchondral bone deterioration. This study analyzed the histological findings of the osteochondral unit after performing MF on subchondral bone in different states (normal, absorption, and sclerosis) in a rat model. The results showed that MF induced enlargement of MF holes, cyst formation, and delayed cartilage defect coverage. Implantation of beta-tricalcium phosphate (beta-TCP) in the MF holes improved the repair of the osteochondral unit compared to MF alone.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Engineering, Biomedical
Elisa Fiume, Alessandro Schiavi, Gissur Orlygsson, Cristina Bignardi, Enrica Verne, Francesco Baino
Summary: Proper microstructural and transport properties are crucial for scaffold design in tissue engineering applications. Evaluating permeability remains a challenge, while pore characteristics are relatively easier to assess.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Paper & Wood
Asif Ali, Abshar Hasan, Yuvraj Singh Negi
Summary: This study investigates the effect of cellulose nanocrystals on xylan/chitosan/beta-tricalcium phosphate matrix for bone tissue construct. The results show that the pore size can be altered by adjusting the filler concentration. The addition of 1% cellulose nanocrystals significantly enhances the compressive modulus and crystalline content of the material. Samples with 5% cellulose nanocrystals exhibit the highest thermal stability, and all composites with beta-TCP content demonstrate improved cell viability, alkaline phosphatase activity, and mineralization tendency.
Article
Engineering, Biomedical
Gyeongjin Joo, Myeongki Park, Seong-su Park, Garima Tripathi, Byong-Taek Lee
Summary: An alginate-tasted polycaprolactone-gelatin-beta-tricalcium phosphate dual membrane was fabricated to enhance new bone formation under guided bone regeneration (GBR) process. The dual layered membrane exhibited compatibility with cells and suppressed fibrous tissue infiltration while promoting bone growth.
BIOMEDICAL MATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Dhanalakshmi Jeyachandran, Marta Cerruti
Summary: Porosity plays a significant role in the performance of scaffolds for bone tissue engineering. Different pore sizes, such as macropores, micropores, and even nanopores, have distinct effects on cellular infiltration, adhesion, nutrient absorption, and cell-material interactions. This review discusses fabrication techniques, pore nomenclature, and the influence of scaffold porosity on mechanical properties and biological activity. It also explores future advancements in this field, including the use of computational modeling and artificial intelligence.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Physical
Lara Schorn, Anna Sine, Karin Berr, Jorg Handschel, Rita Depprich, Norbert R. Kuebler, Christoph Sproll, Majeed Rana, Julian Lommen
Summary: The effect of alloplastic and xenogeneic bone grafting materials on the growth rates and viability of human unrestricted somatic stem cells was investigated in vitro. The results showed that xenogeneic materials promoted the greatest proliferation and improved viability of the cells. Furthermore, the pore size and bioactive characteristics of the scaffolds influenced the proliferation and attachment of the stem cells.
Article
Biotechnology & Applied Microbiology
Qiangqiang Duan, Huiling Liu, Lixia Zheng, Daozhang Cai, Guangxin Huang, Yu Liu, Rui Guo
Summary: Traditional non-resorbable bone wax has been used for over 100 years in clinical surgery, but it can lead to various complications. To address this issue, a novel resorbable bone wax composed of alkylene oxide copolymers, beta-tricalcium phosphate, and starch microspheres was developed. This new material has the potential to be a substitute for traditional bone wax and can enhance bone regeneration and hemostatic ability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)