Article
Biochemistry & Molecular Biology
Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Summary: Ivermectin can induce apoptotic cell death in human neuroblastoma cells, promoting ROS production, mitochondrial dysfunction, and autophagy, while inhibiting the Akt/mTOR pathway. Autophagy inhibition improved Ivermectin-induced oxidative stress and apoptotic cell death in these cells.
Article
Endocrinology & Metabolism
Zhijing Ni, Weiqi Sun, Rui Li, Mingjun Yang, Fen Zhang, Xiuli Chang, Weihua Li, Zhijun Zhou
Summary: This study investigated the mechanism of FLC-induced reproductive toxicity in male mice, focusing on the role of autophagy in TM4 Sertoli cells. FLC exposure caused testicular injuries and increased autophagosome formation, ROS accumulation, and autophagy marker protein expression. In vitro, FLC triggered autophagy in TM4 cells by upregulating autophagosome formation and marker protein levels, while inhibiting AKT/mTOR signaling pathways. NAC and SC79 treatments reversed the effects of FLC-induced autophagy and increased cell viability in TM4 cells.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haibo Zhang, Lei Ma, Eungyung Kim, Junkoo Yi, Hai Huang, Hyeonjin Kim, Muhammad Atif Raza, Sijun Park, Soyoung Jang, Kirim Kim, Sung-Hyun Kim, Youngkyun Lee, Eunkyong Kim, Zae Young Ryoo, Myoung Ok Kim
Summary: This study aimed to investigate the potential anticancer activity and underlying mechanisms of rhein, a natural compound extracted from rhubarb, on oral cancer cells. The results showed that rhein significantly inhibited oral cancer cell growth by inducing apoptosis and S-phase cell cycle arrest. It also inhibited migration and invasion of oral cancer cells through the regulation of epithelial-mesenchymal transition-related proteins. Rhein exerted its anticancer activity by inducing oral cancer cell apoptosis and ROS accumulation via the AKT/mTOR signaling pathway in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yu He, Yuchuan Shi, Yang Yang, Huanhuan Huang, Yifan Feng, Yunmeng Wang, Lei Zhan, Bing Wei
Summary: Chrysin shows potential therapeutic effects on EC by inducing both cell autophagy and apoptosis to inhibit cell proliferation and promote cell death. Additionally, chrysin induces intracellular ROS production, leading to autophagy activation. The study revealed that chrysin-induced autophagy in EC cells is mediated through the inhibition of the ROS-mediated Akt/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Li-Hsien Wu, Christian R. Pangilinan, Che-Hsin Lee
Summary: Thyroid cancer is the most common endocrine malignancy, and Salmonella can inhibit the growth of anaplastic thyroid cancer by activating the autophagy signaling pathway.
Article
Environmental Sciences
Yi Feng, Jubo Wang, Bing Cai, Ximin Bai, Yiru Zhu
Summary: The study found that IVM accelerates autophagic death of glioma cells by inhibiting glycolysis and promoting autophagy, possibly through blocking the GLUT4-mediated JAK/STAT signaling pathway activation.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Xuemei Han, Yan Zhuang
Summary: The study found that PM2.5 significantly decreased lung function in mice, induced inflammatory responses, oxidative injury, and bronchial epithelium cell apoptosis. PM2.5 also increased IL-1β, IL-6 expression, reactive oxygen species production, and induced PI3K, AKT, and mTOR expression in MBECs.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Qianxu Jin, Jiahui Zhao, Zijun Zhao, Shiyang Zhang, Zhimin Sun, Yunpeng Shi, Hongshan Yan, Yizheng Wang, Liping Liu, Zongmao Zhao
Summary: CAMK1D is expressed at lower levels in glioma tissues and is positively correlated with the WHO classification of gliomas. Knockdown of CAMK1D promotes the proliferation, migration, and invasion of glioma cells, while overexpression has the opposite effect. Mechanistically, CAMK1D regulates glioma cell function through the PI3K/AKT/mTOR pathway. These findings suggest that CAMK1D may serve as a prognostic predictor and a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
So Young Kim, Hyun Hwangbo, Min Yeong Kim, Seon Yeong Ji, Hyesook Lee, Gi-Young Kim, Chan-Young Kwon, Sun-Hee Leem, Su Hyun Hong, JaeHun Cheong, Yung Hyun Choi
Summary: The study revealed that coptisine induces autophagy in HCC Hep3B cells through regulating PI3K/Akt/mTOR signaling and mitochondrial ROS production, leading to autophagic cell death and suppression of autophagosome-lysosome fusion.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Kexiang Zhang, Song Wu, Hongwei Wu, Li Liu, Jiahui Zhou
Summary: The study demonstrated that activation of Notch1 by doxycycline effectively suppressed cell proliferation and induced S phase arrest in osteosarcoma cells, while also triggering apoptosis and autophagy. Notch1 activation inhibited the PI3K/Akt/mTOR signaling pathway to induce apoptosis and autophagy.
Article
Biochemistry & Molecular Biology
Jing Zhang, Zhi-Yong Guo, Chang-Lun Shao, Xue-Qing Zhang, Fan Cheng, Kun Zou, Jian-Feng Chen
Summary: This study characterizes the anti-cancer potential of Nigrosporins B, a derivative from marine fungus, in human cervical cancer cells. It was found that Nigrosporins B inhibited cell proliferation, induced apoptosis and autophagy, and suppressed the PI3K/AKT/mTOR signaling pathway. This suggests that Nigrosporins B may be a promising alternative therapeutic agent for cervical cancer.
Article
Oncology
Moumita Kundu, Subhayan Das, Chandan Kanta Das, Gaurav Kulkarni, Soumen Das, Dibakar Dhara, Mahitosh Mandal
Summary: Glioma is difficult to treat due to its invasive nature and the blood-brain barrier. This study discovered that Magnolol, a neolignan, plays an important role in inducing apoptosis and modulating autophagy in glioma cells. The study also found that Magnolol inhibits the PI3K/AKT/mTOR pathway to induce autophagy. The results suggest that Magnolol could be a promising therapeutic agent for glioma management.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xiaohua Wang, Meng Jiang, Hui Lin, Shuyun Zheng, Weiling Wang, Fang Li, Shuying Li
Summary: In this study, it was found that JB inhibited proliferation and migration of HB cells, and induced apoptosis and autophagy. The mechanism of JB's effect on HB cells may involve modulation of the PI3K/AKT/mTOR signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
Summary: The study revealed that high expression of E2F2 in gastric cancer is associated with poor prognosis, and it promotes cancer cell migration and invasion by inhibiting autophagy through the PI3K/Akt/mTOR pathway. E2F2 may also modulate tumor immunity.