Journal
BIOORGANIC CHEMISTRY
Volume 96, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103583
Keywords
Cap analogue; mRNA; Translation initiation; Isoxazol; Cycloaddition reaction
Funding
- National Science Centre, Poland [2016/21/D/ST501654, 2018/31/B/ST5/03544, 2013/08/A/NZ1/00866]
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Herein we describe a synthesis of new isoxazole-containing 5' mRNA cap analogues via a cycloaddition reaction. The obtained analogues show a capability to inhibit cap-dependent translation in vitro and are characterized by a new binding mode in which an isoxazolic ring, instead of guanine, is involved in the stacking effect. Our study provides valuable information toward designing new compounds that can be potentially used as anticancer therapeutics.
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