Article
Medicine, General & Internal
Casey Lee McAtee, Joseph Lubega, Kristen Underbrink, Kristen Curry, Pavlos Msaouel, Martha Barrow, Eyal Muscal, Timothy Lotze, Poyyapakkam Srivaths, Lisa R. Forbes, Carl Allen, Brooke Bernhardt
Summary: Rituximab, a commonly used immunotherapy in pediatrics, is well tolerated among young people with few serious adverse events. However, infections are common, leading to a prolonged period of B cell count recovery often lasting for longer than a year. Further strategies to prevent infections following rituximab should be explored.
Review
Nutrition & Dietetics
Pengzhu Li, Nikolaus Alexander Haas, Robert Dalla-Pozza, Andre Jakob, Felix Sebastian Oberhoffer, Guido Mandilaras
Summary: This review investigates the adverse health events associated with energy drink (ED) consumption in children and adolescents. It found that ED intake may be associated with cardiovascular and neuropsychiatric health events in minors. Additional triggers and preexisting health conditions also play a critical role. To prevent future adverse events, it is important to educate children and adolescents about risk factors and responsible consumption behaviors.
Article
Psychiatry
Laura Ylitervo, Juha Veijola, Anu-Helmi Halt
Summary: The objective of this study was to examine whether parents' adverse childhood events (ACEs) increase the child's risk of experiencing emotional neglect. The results showed that only the father's ACEs were associated with the child's emotional neglect score. This suggests that childhood adversities may be transferred from fathers to children, but larger samples are needed to confirm these findings.
EUROPEAN PSYCHIATRY
(2023)
Review
Pediatrics
Alessandra Bosch, Manuela Albisetti
Summary: Venous thromboembolism (VTE) is becoming increasingly significant in pediatric patients. Current standardized anticoagulants have not been comprehensively tested in pediatric patients. Direct oral anticoagulants (DOACs) have shown to be safe and effective in the treatment and secondary prevention of pediatric VTE. This review focuses on adverse events (AEs) of specific DOACs reported in clinical trials in children and compares them to standard care, aiding clinicians in selecting the right anticoagulation for pediatric patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Keith M. Harris, Lu Wang, Guanglun M. Mu, Yanxia Lu, Cheryl So, Wei Zhang, Jing Ma, Kefei Liu, Wei Wang, Melvyn Wei-bin Zhang, Roger C. Ho
Summary: Clinicians face challenges in providing accurate and useful mental health assessments, especially in emergency situations. The development of a reliable and accessible Suicidality Scale (SS) addresses the urgent need for better suicide risk assessment tools. Through rigorous testing and validation, the SS has demonstrated strong psychometric properties and is applicable to diverse populations. This open-source scale represents a significant advancement in accurate assessment for individuals aged 13 and older.
Article
Dermatology
David-Dan Nguyen, Maya Marchese, Eugene B. Cone, Marco Paciotti, Shehzad Basaria, Naeem Bhojani, Quoc-Dien Trinh
Summary: This study investigated the potential association between finasteride use and suicidal tendencies, depression, and anxiety, finding a disproportional signal primarily in younger patients with alopecia. The findings suggest that younger patients and those with alopecia may be more vulnerable to these adverse effects of finasteride, but further research is needed to confirm these findings.
Article
Pediatrics
Marie-Line Menard, Philippe Auby, Coralie Cruzel, David Cohen, Olivier Bonnot, Florence Askenazy, Susanne Thummler
Summary: An additional analysis from the French ETAPE study highlights the prevalence of psychiatric adverse events in the pediatric population, emphasizing the need to consider the potential risks in the evaluation and follow-up.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2022)
Article
Medicine, General & Internal
Sonya Negriff, Mercie J. DiGangi, Margo Sidell, Jialuo Liu, Karen J. Coleman
Summary: The implementation of an intervention that included additional screening questions and incorporated social workers into the process of evaluation and referral for behavioral health needs following ACEs screening resulted in an increased receipt of behavioral health services among children and adolescents with a positive ACEs screening.
Article
Health Care Sciences & Services
Christopher M. Worsham, Jaemin Woo, Anupam B. Jena, Michael L. Barnett
Summary: Understanding the risks associated with opioid prescription in adolescents is crucial for informing opioid policy. Using a regression discontinuity design, a study found that adolescents just over age eighteen were more likely to be prescribed opioids and have adverse opioid-related events compared to those just under age eighteen. The results suggest that differences in care provided in pediatric versus adult care settings may play an important role in understanding prescribers' roles in the opioid epidemic.
Article
Immunology
Chae Won Lee, Soonok Sa, Myunghee Hong, Jihyun Kim, Sung Ryul Shim, Hyun Wook Han
Summary: A recent study compared the incidence of adverse events in adolescents and adults after vaccination with COVID-19 vaccine BNT162b2 (Pfizer-BioNTech). The study found that the risk of myocarditis or pericarditis among adolescents was significantly higher in men than in women, especially after the second dose of the vaccine. Additionally, severe adverse events such as multisystem inflammatory syndromes were significantly higher in adolescents than in adults.
Article
Medicine, General & Internal
Helene Kildegaard, Lars Christian Lund, Mikkel Hojlund, Lone Graff Stensballe, Anton Pottegard
Summary: This study in Denmark found that the risk of acute and post-acute adverse events after SARS-CoV-2 infection in children and adolescents was generally low, but the occurrence of MIS-C was slightly higher. The real world effectiveness of the BNT162b2 mRNA vaccine showed good results in reducing the risk of infection among adolescents with the delta variant.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Family Studies
Eunice M. Areba, Lindsay A. Taliaferro, Myriam Forster, Barbara J. McMorris, Michelle A. Mathiason, Marla E. Eisenberg
Summary: The study highlights the impact of ACEs on suicidal ideation and attempts, with school connectedness potentially serving as a protective factor. Further research is needed to identify factors that can moderate the effects of ACEs among adolescents of diverse ethnic backgrounds.
CHILDREN AND YOUTH SERVICES REVIEW
(2021)
Review
Criminology & Penology
Yuri Flach, Timothy S. Razza
Summary: This article conducted a systematic review of the literature to investigate potential factors associated with suicidality among homeless children and adolescents. The review identified significant risk factors, such as gender, sexual orientation, history of abuse, mental health diagnoses, negative coping styles, duration of homelessness, and survival sex. In contrast, protective factors associated with suicidality among homeless youth were found to include resilience, positive coping strategies, and supportive school environment.
AGGRESSION AND VIOLENT BEHAVIOR
(2022)
Article
Psychology, Developmental
Verena Hinze, Anke Karl, Tamsin Ford, Bergljot Gjelsvik
Summary: This study used data from the British Child and Adolescent Mental Health Survey to investigate the relationship between different pain trajectories and suicidality in young people. The study found that pain trajectories were associated with demographic and clinical factors, and the persistent/recurrent pain trajectory had a higher association with suicidality and predicted future suicidality.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Michael W. Lippert, Katharina Sommer, Tabea Flasinski, Verena Pflug, Angela Rolver, Hanna Christiansen, Tina In-Albon, Susanne Knappe, Marcel Romanos, Brunna Tuschen-Caffier, Silvia Schneider
Summary: In treating childhood anxiety disorders, therapists use personalized anxiety hierarchies, while standardized questionnaires prioritize comparability. The AVAC questionnaire, based on a precise, personalized assessment approach, shows good reliability in measuring anxiety and avoidance in children.
FRONTIERS IN PSYCHOLOGY
(2021)
Correction
Psychology, Clinical
Pascal-M Aggensteiner, Nathalie E. Holz, Boris W. Bottinger, Sarah Baumeister, Sarah Hohmann, Julia E. Werhahn, Jilly Naaijen, Shahrzad Ilbegi, Jeffrey C. Glennon, Pieter J. Hoekstra, Andrea Dietrich, Renee Kleine Deters, Melanie C. Saam, Ulrike M. E. Schulze, David J. Lythgoe, Arjun Sethi, Michael C. Craig, Mathilde Mastroianni, Ilyas Sagar-Ouriaghli, Paramala J. Santosh, Mireia Rosa, Nuria Bargallo, Josefina Castro-Fornieles, Celso Arango, Maria J. Penzol, Jorge Vidal, Barbara Franke, Marcel P. Zwiers, Jan K. Buitelaar, Susanne Walitza, Tobias Banaschewski, Daniel Brandeis
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Alexis Revet, Johannes Hebebrand, Dimitris Anagnostopoulos, Laura A. Kehoe, Gertraud Gradl-Dietsch, Paul Klauser
Summary: This report presents the findings from a survey on the impact of COVID-19 on child and adolescent psychiatry services in Europe. While service delivery was significantly affected at the beginning of the pandemic, the second survey showed a minor impact on care delivery. However, there was a dramatic increase in the perceived impact on the mental health and psychopathology of children and adolescents. Suicidal crises, anxiety disorders, eating disorders, and major depressive episodes were particularly affected. There was a substantial increase in referrals or requests for assessments, and CAP department heads expressed concerns about the long-term consequences of the crisis.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Esther Via, Anna Calvo, Elena de la Serna, Anna Blazquez, Luisa Lazaro, Susana Andres-Perpina, Maria Teresa Plana, Itziar Flamarique, Esteve Martinez, Jose Pariente, Elena Moreno, Nuria Bargallo, Josefina Castro-Fornieles
Summary: Resting-state connectivity in the cortico-striatal system (CSTS) and default mode network (DMN) is altered in adolescent patients with anorexia nervosa (AN). These alterations improve with weight and symptom improvement and may be associated with changes in inhibitory processing performance.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Psychology, Developmental
David Coghill, Tobias Banaschewski, Samuele Cortese, Philip Asherson, Daniel Brandeis, Jan Buitelaar, David Daley, Marina Danckaerts, Ralf W. Dittmann, Manfred Doepfner, Maite Ferrin, Chris Hollis, Martin Holtmann, Santosh Paramala, Edmund Sonuga-Barke, Cesar Soutullo, Hans-Christoph Steinhausen, Saskia van der Oord, Ian C. K. Wong, Alessandro Zuddas, Emily Simonoff
Summary: ADHD is a common neurodevelopmental disorder in children and adolescents, and timely interventions are a priority. However, current research reports and reviews on interventions for ADHD often lack consistency and are difficult to interpret. Clinicians need to consider methodological issues and gaps in the evidence when evaluating treatments for ADHD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Neurosciences
Nuria Prades, Eva Varela, Itziar Flamarique, Ramon Deulofeu, Inmaculada Baeza
Summary: Nutrition is crucial for brain development, and this study investigates the levels of water-soluble vitamins (WSV) and the effects of supplementation on psychiatric symptoms in children and adolescents with psychiatric disorders. The results show that individuals with Autism Spectrum Disorders (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) have lower levels of vitamin B-12 and higher levels of folate. Supplementation with WSV leads to a decrease in symptoms as measured by clinical scales.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Cecile Louveau, Pierre Ellul, Anton Iftimovici, Julien Dubreucq, Charles Laidi, Quentin Leyrolle, Diane Purper-Ouakil, Sebastien Jacquemont, Stanislas Lyonnet, Catherine Barthelemy, Marie-Odile Krebs, Jing Bai, Paul Olivier, Boris Chaumette
Summary: The 2nd Webinar Neurodevelopmental Disorders (NDD) without boundaries was held in June 2022 at the Imagine Institute in Paris, discussing NDD in a dimensional approach. Various speakers presented their research on NDD classifications and psychiatric disorders. The continuum between NDD and adult psychiatric presentations was emphasized, which could impact therapeutic strategies and the development of new psychotherapies. The complexity and heterogeneity of NDD present challenges for future scientific and political efforts to expand knowledge boundaries.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Editorial Material
Psychology, Developmental
Diane Purper-Ouakil
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Ann Ozsivadjian, Victoria Milner, Hannah Pickard, Matthew J. Hollock, Sebastian B. Gaigg, Emma Colvert, Francesca Happe, Iliana Magiati
Summary: Autistic children and young people have poorer mental health and well-being compared to their non-autistic peers. Navigating the complex aspects of school can be challenging for autistic young people, contributing to their poorer mental well-being. The COVID-19 pandemic provided an opportunity to understand the impact of school changes on the well-being of both autistic and non-autistic young people. Surveys were conducted with caregivers and young people aged 11-18, revealing both benefits and challenges of school changes. Insights from the pandemic and recommendations for more flexible and individualized educational practices are discussed.
Article
Psychology, Developmental
Lucy Adams, Nicoletta Adamo, Matthew J. Hollocks, Jennifer Watson, Aylana Brewster, Lucia Valmaggia, Emma Jewitt, Jodie Edwards, Maisie Krisson, Emily Simonoff
Summary: Remote psychological interventions have both challenges and benefits for individuals with autism spectrum disorder. A study interviewed autistic individuals and clinicians, finding that there are barriers and challenges to remote delivery, but also potential benefits for some individuals. Most participants supported the provision of hybrid delivery post-pandemic.
Article
Clinical Neurology
Larissa S. van Bodegom, Suzanne E. Gerritsen, Gwendolyn C. Dieleman, Mathilde M. Overbeek, Giovanni de Girolamo, Paolo Scocco, Manon H. J. Hillegers, Dieter Wolke, Dimitris Rizopoulos, Rebecca Appleton, Patrizia Conti, Tomislav Franic, Francesco Margari, Jason Madan, Fiona McNicholas, Renata Nacinovich, Adriana Pastore, Moli Paul, Diane Purper-Ouakil, Melanie C. Saam, Paramala J. Santosh, Anne Sartor, Ulrike M. E. Schulze, Giulia Signorini, Swaran P. Singh, Cathy Street, Priya Tah, Elena Tanase, Sabine Tremmery, Helena Tuomainen, Athanasios Maras
Summary: This study investigated the awareness of clinicians and parents regarding adolescent suicidal behavior in a sample of 763 Child and Adolescent Mental Health Service (CAMHS) users from eight European countries. The results showed that a significant proportion of clinicians and parents were unaware of the suicidal behavior reported by the adolescents. However, this lack of awareness did not have an impact on mental health problems or the use of mental health services by the adolescents.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Behavioral Sciences
Elie Khoury, Eric Acquaviva, Diane Purper-Ouakil, Richard Delorme, Pierre Ellul
Summary: This meta-analysis demonstrates a clear overlap between ADHD and BD, with shared genetic, neurobiological, and clinical factors. Personal history of ADHD increases the risk of BD, and individuals with BD also have an increased risk of ADHD. First-degree relatives of both disorders also have an increased risk of the other disorder. This highlights the importance of systematic screening for ADHD and BD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Martina Puzio, Niamh Moreton, Mairead Sullivan, Caitriona Scaife, Jeffrey C. Glennon, John J. O'Connor
Summary: Metabolic stress and ROS production contribute to neuronal damage and synaptic plasticity in acute ischemic stroke. MnTMPyP has a neuroprotective effect in hippocampal slices and regulates synaptic transmission during hypoxia and OGD. This study investigates the molecular changes and mechanisms involved in the effect of MnTMPyP, revealing impairments in vesicular trafficking and cell differentiation signaling. These findings provide insights into the role of MnTMPyP in synaptic transmission and plasticity during ischemia.
Article
Clinical Neurology
Andrew Laurin, Samuel Bulteau, Pascal Caillet, Pascal Artari, Anne Sauvaget, Fanny Gollier-Briant, Jean-Franois Huon, Olivier Bonnot
Summary: The COVID-19 pandemic and lockdowns in France had a negative impact on mental health, especially in vulnerable subgroups. Monitoring psychotropic drugs consumption is a reliable tool for analyzing French people's mental health. A historical cohort study found an increase in weekly trend of psychotropic drugs users from 2019 to 2020, with the greatest increase in young people and patients not being socially deprived. The French drugs delivery system was able to adapt and maintain its capacity to deliver psychotropic treatments despite the increase in consumers and restrictive health measures during lockdowns.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Antoine Oudin, Redwan Maatoug, Alexis Bourla, Florian Ferreri, Olivier Bonnot, Bruno Millet, Felix Schoeller, Stephane Mouchabac, Vladimir Adrien
Summary: Digital phenotype refers to the digital footprint left by patient-environment interactions. It has potential benefits in mental health and psychiatry, enabling treatment and empowering patients, but also poses a risk of excluding the human element of care by potentially excluding health care professionals.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
