Journal
BIOMARKERS IN MEDICINE
Volume 13, Issue 17, Pages 1439-1446Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2018-0446
Keywords
coronary slow flow syndrome; correlation; homocysteine; predictor; prognosis
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Funding
- Beijing Science and Technology Nova project [2013106]
- Chinese Cardiovascular Association VG Foundation
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Aim: To identify the exact molecular markers related to coronary slow flow syndrome (CSFS) and its prognosis. Patients & methods: Data from 54 patients with CSFS diagnosed by coronary angiography and 101 normal control patients were collected and analyzed. Results: Logistic regression analysis confirmed that homocysteine (Hcy; odds ratio: 1.107; 95% CI: 1.018-1.205; p = 0.018) was associated with CSFS. Receiver-operating characteristic curve analysis identified an Hcy value of 17.1 mu mol/l as an effective cut-off point for predicting CSFS. Cox survival analysis showed a relationship between high admission Hcy level (odds ratio: 1.19; 95% CI = 1.05-1.34; p = 0.005) and recurrent angina. Conclusion: Our results showed positive correlations of Hcy with CSFS and cardiac events.
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