Article
Virology
Sebastien Barral, Aline Mamin, Carole Dantin, Stavroula Masouridi-Levrat, Yves Chalandon, Laurent Kaiser, Diem-Lan Vu
Summary: This retrospective observational study found that rhinovirus infections are the most common in allo-HSCT patients, including pre-transplant infections. However, the mortality rate due to pre-transplant RVIs is low.
Review
Infectious Diseases
Kasama Manothummetha, Thanuthong Mongkolkaew, Punyot Tovichayathamrong, Rabhas Boonyawairote, Tanaporn Meejun, Karan Srisurapanont, Kasidis Phongkhun, Anawin Sanguankeo, Pattama Torvorapanit, Chatphatai Moonla, Rongpong Plongla, Olivia S. Kates, Robin K. Avery, Saman Nematollahi, Nitipong Permpalung
Summary: This study summarized the efficacy of ribavirin in treating respiratory syncytial virus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients. The results showed that ribavirin use did not significantly affect all-cause mortality and RSV-associated mortality, but it was associated with lower mortality and progression to lower respiratory tract infection in certain subgroups.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Biophysics
Rosalia De la Puerta, Juan Montoro, Carla Aznar, Ignacio Lorenzo, Eva Maria Gonzalez-Barbera, Aitana Balaguer-Rosello, Manuel Guerreiro, Lara Dominguez, Miguel Salavert, Cristobal Aguilar, Javier de la Rubia, Jaime Sanz, Maria Dolores Gomez, Jose Luis Pinana
Summary: During the SARS-COV-2 pandemic, there was a significant decrease in the circulation of common seasonal respiratory viruses in allo-HSCT recipients. This suggests that prevention measures in the general population are highly effective in reducing the prevalence of CSRV and its complications in immunocompromised patients.
BONE MARROW TRANSPLANTATION
(2021)
Article
Respiratory System
Patrick M. Wieruszewski, Heather P. May, Steve G. Peters, Ognjen Gajic, William J. Hogan, Ross A. Dierkhising, Hassan B. Alkhateeb, Hemang Yadav
Summary: PERDS is a common complication following autologous HCT, associated with higher mortality and healthcare utilization. Radiographic evidence of pulmonary involvement precedes hematopoietic recovery. Risk factors for PERDS include female sex, number of platelet transfusions, and more rapid engraftment.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Hematology
Katie Maurer, Anna Saucier, Haesook T. Kim, Utkarsh Acharya, Clifton C. Mo, Julie Porter, Cindy Albert, Corey Cutler, Joseph H. Antin, John Koreth, Mahasweta Gooptu, Rizwan Romee, Catherine J. Wu, Robert J. Soiffer, Sarah Nikiforow, Caron Jacobson, Vincent T. Ho
Summary: The impact of the COVID-19 pandemic on operations and clinical outcomes for HSCT and CAR-T cellular therapies was assessed, with no significant differences observed in outcomes between patients treated during and before the pandemic. Proper safeguards allowed for the safe administration of cellular therapies throughout the ongoing pandemic.
Article
Oncology
Courtney M. Rowan, Julie C. Fitzgerald, Asya Agulnik, Matt S. Zinter, Matthew P. Sharron, James E. Slaven, Erin M. Kreml, Rajinder P. S. Bajwa, Kris M. Mahadeo, Jerelyn Moffet, Keiko M. Tarquinio, Marie E. Steiner
Summary: Respiratory rate at 4 hours and vasoactive use were identified as independent risk factors of NIPPV failure in this study. Additionally, 14% of patients experienced a cardiac arrest during intubation, with some others arresting prior to intubation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wanessa Miranda-Silva, Vinicius Campos de Molla, Franciele Hinterholz Knebel, Tania Regina Tozetto-Mendoza, Celso Arrais-Rodrigues, Anamaria Aranha Camargo, Paulo Henrique Braz-Silva, Eduardo Rodrigues Fregnani
Summary: This study investigated the oral shedding of herpes viruses in patients who underwent alloHSCT and found that the presence of certain herpesviruses in the oral cavity was associated with clinical outcomes such as acute graft-versus-host disease, relapse, and overall survival.
Article
Microbiology
Baptiste Demey, Clement Brault, Julien Maizel, Catherine Francois
Summary: Adenovirus infection is rare in adults, but more common in immunocompromised individuals. Patients undergoing allogenic haploidentical hematopoietic stem cell transplantation are at high risk, and prevention, early diagnosis, and treatment continue to pose challenges.
Article
Virology
Chikara Ogimi, Hu Xie, Alpana Waghmare, Keith R. Jerome, Wendy M. Leisenring, Filippo Milano, Janet A. Englund, Michael Boeckh
Summary: This study evaluated whether the initial viral burden of upper respiratory tract infection (URTI) viruses predicts the risk of progression to lower respiratory tract infection (LRTI) in adult allogeneic hematopoietic cell transplant (HCT) recipients. The study found that higher viral burden was associated with an increased risk of progression to LRTI for influenza, but not for other viruses.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
D. G. Partridge, A. Sori, D. J. Green, R. Simpson, B. Poller, M. Raza, H. Kaur, H. Jessop, B. Colton, A. Nield, C. M. Evans, A. Lee
Summary: This study, conducted before the COVID-19 pandemic, examined the impact of a universal mask use policy on respiratory viral infection rates in stem cell transplant patients. The findings showed a significant decrease in respiratory viral infections after the implementation of the policy. Education was highlighted as a key factor in the successful implementation of the policy.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Hematology
Yae-Jean Kim, Alpana Waghmare, Hu Xie, Leona Holmberg, Steven A. Pergam, Keith R. Jerome, Wendy M. Leisenring, Chikara Ogimi, Angela P. Campbell, Janet A. Englund, Michael Boeckh
Summary: Pretransplant respiratory virus infections have a negative impact on hematopoietic cell transplantation outcomes. The controversy remains regarding the impact and need for delay of transplantation for pretransplant infection with human rhinovirus (HRV) or endemic human coronavirus (HCoV). In this study, it was found that pretransplant upper respiratory tract infection with HRV and endemic HCoV was not associated with increased mortality or fewer days alive and out of hospital (DAOH). However, for allogeneic recipients receiving myeloablative conditioning, lower respiratory tract disease (LRD) due to any respiratory virus, including HRV alone, was associated with increased overall mortality and fewer DAOH.
Article
Immunology
Michael Koldehoff, Peter A. Horn, Monika Lindemann
Summary: This study demonstrates that vaccination with Shingrix (TM) enhances cellular, VZV-specific immunity in hematopoietic stem cell transplant (HSCT) recipients. Shingles and male sex were identified as factors leading to increased immunity.
Article
Virology
Barbara N. Porto, Michael L. Litvack, Yuchen Cen, Irene Lok, Sheena Bouch, Michael J. Norris, Wenming Duan, Cameron Ackerley, Martin Post, Theo J. Moraes
Summary: The study demonstrates that ALMs generated from pluripotent stem cells can prevent RSV infection by phagocytosis of virus particles and releasing an antiviral factor. ALMs protect mice from virus-induced weight loss and reduce lung inflammation in experiments, indicating their potential prophylactic role in RSV infection.
Article
Medicine, Research & Experimental
Erin W. Meermeier, Leif Bergsagel
Summary: Multiple myeloma is a malignant disease characterized by bone marrow tumors and bone lesions. Autologous stem cell transplantation followed by lenalidomide maintenance therapy is the standard treatment for multiple myeloma. However, relapse is common. In this study, the addition of a checkpoint inhibitor to lenalidomide maintenance therapy was investigated and found to enhance the immune response and improve the efficacy of the treatment in a mouse model of multiple myeloma.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Michael Koldehoff, Britta Eiz-Vesper, Britta Maecker-Kolhoff, Nina K. Steckel, Ulf Dittmer, Peter A. Horn, Monika Lindemann
Summary: The effect of virus-specific T cells (VSTs) in treating BK virus (BKV)-related cystitis in hematopoietic stem cell transplant (HSCT) recipients was compared to other treatment options in this study. BKV-specific cellular responses were observed in HSCT recipients treated with VSTs, and the ELISpot assay was found suitable for monitoring BKV-specific cellular immunity in HSCT recipients. The absolute CD4+ T-cell numbers and renal function were correlated with BKV-specific cellular responses in HSCT recipients treated for BKV-related cystitis.
Article
Hematology
Deepak Singhal, Monika M. Kutyna, Rakchha Chhetri, Li Yan A. Wee, Sophia Hague, Lakshmi Nath, Shriram V. Nath, Romi Sinha, Nicholas Wickham, Ian D. Lewis, David M. Ross, Peter G. Bardy, Luen Bik To, John Reynolds, Erica M. Wood, David J. Roxby, Devendra K. Hiwase
Letter
Oncology
Kyaw Ze Ya Maung, Paul J. Leo, Mahmoud Bassal, Debora A. Casolari, James X. Gray, Sarah C. Bray, Stephen Pederson, Deepak Singhal, Saumya E. Samaraweera, Tran Nguyen, Gokhan Cildir, Mhairi Marshall, Adam Ewing, Emma L. Duncan, Matthew A. Brown, Russell Saal, Vinay Tergaonkar, Luen Bik To, Paula Marlton, Devinder Gill, Ian Lewis, Andrew J. Deans, Anna L. Brown, Richard J. D'Andrea, Thomas J. Gonda
BLOOD CANCER JOURNAL
(2018)
Letter
Hematology
Rakchha Chhetri, Li Yan A. Wee, Romi Sinha, Monika M. Kutyna, Anh Pham, Helen Stathopoulos, Lakshmi Nath, Shriram V. Nath, Nicholas Wickham, Tim Hughes, Deepak Singhal, David J. Roxby, Devendra K. Hiwase
Article
Oncology
Deepak Singhal, Li Yan A. Wee, Monika M. Kutyna, Rakchha Chhetri, Joel Geoghegan, Andreas W. Schreiber, Jinghua Feng, Paul P. -S. Wang, Milena Babic, Wendy T. Parker, Smita Hiwase, Suzanne Edwards, Sarah Moore, Susan Branford, Teodora Kuzmanovic, Nimit Singhal, Raghu Gowda, Anna L. Brown, Peer Arts, Luen B. To, Peter G. Bardy, Ian D. Lewis, Richard J. D'Andrea, Jaroslaw P. Maciejewski, Hamish S. Scott, Christopher N. Hahn, Devendra K. Hiwase
Article
Oncology
Angela Molga, Michelle Wall, Rakchha Chhetri, Li Yan Wee, Deepak Singhal, Suzanne Edwards, Nimit Singhal, David Ross, Luen Bik To, Gillian Caughey, Sepehr Shakib, Ulrich Germing, Timothy To, Devendra Hiwase
JOURNAL OF GERIATRIC ONCOLOGY
(2020)
Letter
Hematology
Teodora Kuzmanovic, Bhumika J. Patel, Srinivasa R. Sanikommu, Yasunobu Nagata, Hassan Awada, Cassandra M. Kerr, Bartlomiej P. Przychodzen, Babal K. Jha, Devendra Hiwase, Deepak Singhal, Anjali S. Advani, Aziz Nazha, Aaron T. Gerds, Hetty E. Carraway, Mikkael A. Sekeres, Sudipto Mukherjee, Jaroslaw P. Maciejewski, Tomas Radivoyevitch
Article
Oncology
Kirsty Sharplin, Li Yan A. Wee, Deepak Singhal, Suzanne Edwards, Silke Danner, Ian Lewis, Daniel Thomas, Andrew Wei, Agnes S. M. Yong, Devendra K. Hiwase
Summary: In older patients with acute myeloid leukemia (AML), intensive chemotherapy and hypomethylating agents are associated with significantly higher median overall survival compared to best supportive care. These treatments also lower the likelihood of spending a significant portion of survival time in the hospital. Despite most patients being referred to palliative care, a considerable percentage still die in the hospital setting.
JOURNAL OF GERIATRIC ONCOLOGY
(2021)
Article
Hematology
Kathleen P. L. Cheok, Rakchha Chhetri, Li Yan A. Wee, Oisin Friel, Anh Pham, Arabelle Salvi, Simon McRae, Peter Bardy, Deepak Singhal, David J. Roxby, Erica M. Wood, Devendra K. Hiwase
Article
Oncology
Deepak Singhal, Christopher N. Hahn, Simone Feurstein, Li Yan A. Wee, Luke Moma, Monika M. Kutyna, Rakchha Chhetri, Leila Eshraghi, Andreas W. Schreiber, Jinghua Feng, Paul P-S Wang, Milena Babic, Wendy T. Parker, Song Gao, Sarah Moore, Soma Das, David Thomas, Swetansu Pattnaik, Anna L. Brown, Richard J. D'Andrea, Nicola K. Poplawski, Daniel Thomas, Hamish S. Scott, Lucy A. Godley, Devendra K. Hiwase
Summary: The study found that 13% of patients with hematological malignancies and other independent cancers had pathogenic germline variants (PGVs), with the most common being in CHEK2, BRCA1, DDX41, and TP53. Screening for PGVs can be triggered by a history of multiple cancers.
Review
Pathology
Anoop K. Enjeti, Rishu Agarwal, Piers Blombery, Lynette Chee, Chong Chyn Chua, Andrew Grigg, Nada Hamad, Harry Iland, Steven Lane, Andrew Perkins, Deepak Singhal, Courtney Tate, Ing Soo Tiong, David M. Ross
Summary: This review provides an expert consensus statement on the role of gene-panel testing in the diagnosis, prognosis, and management of adult MDS/MPN overlap syndromes in Australia. The consensus statement was developed by an expert group actively involved in gene-panel testing in the field of MDS/MPN in Australia. The authors were selected based on their laboratory involvement in gene-panel testing, specific interest in MDS/MPN, and publication record in the field. At least two authors reviewed each section, and a diagnostic algorithm was developed through consensus among all authors.
Article
Hematology
Caner Saygin, Gregory Roloff, Christopher N. Hahn, Rakchha Chhetri, Saar Gill, Hany Elmariah, Chetasi Talati, Emma Nunley, Guimin Gao, Aelin Kim, Michael Bishop, Satyajit Kosuri, Soma Das, Deepak Singhal, Parvathy Venugopal, Claire C. Homan, Anna Brown, Hamish S. Scott, Devendra Hiwase, Lucy A. Godley
Summary: There is growing recognition that pathogenic germ line variants play a role in the development of hematopoietic cancers. Patients with myeloid malignancies and deleterious germ line DDX41 variants have a higher incidence of severe acute GVHD. The use of posttransplant cyclophosphamide can reduce the risk of severe acute GVHD in these patients.
Article
Immunology
Philip R. Selby, Morgyn S. Warner, Sandra L. Peake, Peter Bardy, Devendra Hiwase, Deepak Singhal, Ashanka Beligaswatte, Uwe Hahn, Jason A. Roberts, David Yeung, Sepehr Shakib
Summary: A retrospective observational cohort study evaluated the tolerability, efficacy, and cost of a new antifungal prophylaxis pathway in early post allogeneic hematopoietic stem cell transplant. The study found that the new prophylaxis pathway resulted in reduced adverse effects, decreased need for higher-line prophylaxis, and reduced drug costs.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Letter
Hematology
Natalie Montarello, Alasdair Leslie, Rakchha Chhetri, Oisin Friel, Deepak Singhal, David Ross, David Yeung, Chung H. Kok, Peter J. Psaltis, Devendra K. Hiwase
Article
Hematology
Devendra K. Hiwase, Deepak Singhal, Corinna Strupp, Rakchha Chhetri, Monika M. Kutyna, L. Amilia Wee, Peter B. Harrison, Shriram V. Nath, Nicholas Wickham, Chi-Hung Hui, James X. Gray, Peter Bardy, David M. Ross, Ian D. Lewis, John Reynolds, L. Bik To, Ulrich Germing
AMERICAN JOURNAL OF HEMATOLOGY
(2017)