Review
Engineering, Multidisciplinary
Shiva Rangwani, Devarshi R. Ardeshna, Brandon Rodgers, Jared Melnychuk, Ronald Turner, Stacey Culp, Wei-Lun Chao, Somashekar G. Krishna
Summary: The incidence of incidentally detected pancreatic cystic lesions (PCLs) has increased over the past decade, with each subtype carrying a different risk of malignant transformation. Accurate risk stratification of PCLs is crucial for providing appropriate care. However, existing guidelines and diagnostic information fall short in this regard. Clinicians are now turning to artificial intelligence to aid in the management of these challenging lesions.
Article
Oncology
Yingying Cao, Rui Zhao, Kai Guo, Shuai Ren, Yaping Zhang, Zipeng Lu, Lei Tian, Tao Li, Xiao Chen, Zhongqiu Wang
Summary: This study developed a novel metabolic model using both serum and tissue samples for early detection of stage-I pancreatic ductal adenocarcinoma (PDAC). The model showed high diagnostic accuracy and outperformed the traditional CA19-9 marker.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Joanna Jiang, Wei-Lun Chao, Stacey Culp, Somashekar G. Krishna
Summary: Pancreatic cancer is projected to become the second leading cause of cancer-related mortality. Artificial intelligence is being used to improve the screening and prognostication of precancerous lesions in the pancreas. This review summarizes the current literature on the application of AI in the diagnosis and management of premalignant lesions that may progress to pancreatic cancer.
Review
Biochemistry & Molecular Biology
Reiko Yamada, Junya Tsuboi, Yumi Murashima, Takamitsu Tanaka, Kenji Nose, Hayato Nakagawa
Summary: Pancreatic cancer is often diagnosed at late stages, making treatment difficult. Early diagnosis is crucial, but it can be challenging due to nonspecific symptoms. Recent studies suggest that selective screening and biomarkers can improve early detection. This review discusses advancements in imaging, biomarkers, biopsies, surveillance, and machine learning for identifying high-risk individuals. These new methods and techniques have the potential to improve overall survival in pancreatic cancer patients.
Review
Cell Biology
Christian Prinz, Leonard Fehring, Robin Frese
Summary: The dysregulation of microRNAs has been found to be associated with cancer development and progression in pancreatic ductal adenocarcinoma and cystic pancreatic lesions. Specific microRNAs have been investigated as potential predictive biomarkers for cancer presence in solid tumor tissue and blood samples, while different microRNAs have been found to be valuable in differentiating benign and malignant lesions in cystic pancreatic cancer and premalignant lesions. However, further research is needed to fully understand the role of microRNAs in predicting cancer presence and outcomes.
Article
Chemistry, Analytical
Amy Makler, Ramaswamy Narayanan, Waseem Asghar
Summary: Exosomal miRNA may be used for early detection of PDAC and potentially differentiate patients with chronic pancreatitis, neoplasms, and PDAC. The study identified 18 miRNA with strong potential, and 7 mature miRs showed statistical significance in exosomal RNA.
Article
Oncology
Jingru Yu, Alexander Ploner, Maximilian Kordes, Matthias Lohr, Magnus Nilsson, Maria Evangelina Lopez de Maturana, Lidia Estudillo, Harald Renz, Alfredo Carrato, Xavier Molero, Francisco X. Real, Nuria Malats, Weimin Ye
Summary: This study identified and externally validated a panel of eight protein biomarkers that can potentially allow early detection of pancreatic ductal adenocarcinoma (PDAC). The proteins were able to distinguish between early PDAC and healthy individuals, as well as between advanced PDAC and healthy controls, in two populations.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Masahiro Tsujimae, Atsuhiro Masuda, Takuya Ikegawa, Takeshi Tanaka, Jun Inoue, Hirochika Toyama, Keitaro Sofue, Hisahiro Uemura, Shinya Kohashi, Noriko Inomata, Kae Nagao, Shigeto Masuda, Shohei Abe, Masanori Gonda, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Shunta Tanaka, Ryota Nakano, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Maki Kanzawa, Tomoo Itoh, Takumi Fukumoto, Yoshihide Ueda, Yuzo Kodama
Summary: This study found that PDAC concomitant with IPMN has tumor characteristics similar to those of conventional PDAC in terms of major driver gene alterations, tumor microenvironment, and prognosis.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Neus Martinez-Bosch, Helena Cristobal, Mar Iglesias, Meritxell Gironella, Luis Barranco, Laura Visa, Domenico Calafato, Silvia Jimenez-Parrado, Julie Earl, Alfredo Carrato, Noemi Manero-Ruperez, Mireia Moreno, Albert Morales, Carmen Guerra, Pilar Navarro, Pablo Garcia de Frutos
Summary: This study explores the use of sAXL as a biomarker for pancreatic ductal adenocarcinoma (PDAC). The research shows that AXL is increased in PDAC tissues and plasma sAXL concentrations are elevated in PDAC patients. Higher levels of AXL are associated with lower overall survival. sAXL performs better than CA19-9 in discriminating between PDAC and chronic pancreatitis (CP). The combination of sAXL and CA19-9 improves the diagnostic value.
Article
Gastroenterology & Hepatology
Kota Nakamura, Zhongxu Zhu, Souvick Roy, Eunsung Jun, Haiyong Han, Ruben M. Munoz, Satoshi Nishiwada, Geeta Sharma, Derek Cridebring, Frederic Zenhausern, Seungchan Kim, Denise J. Roe, Sourat Darabi, In-Woong Han, Douglas B. Evans, Suguru Yamada, Michael J. Demeure, Carlos Becerra, Scott A. Celinski, Erkut Borazanci, Susan Tsai, Yasuhiro Kodera, Joon Oh Park, John S. Bolton, Xin Wang, Song Cheol Kim, Daniel Von Hoff, Ajay Goel
Summary: This study developed an exosome-based liquid biopsy signature for the noninvasive and robust detection of patients with PDAC, showing high accuracy and specificity through genome-wide profiling and qRT-PCR assays.
Review
Oncology
Swathikan Chidambaram, Michal Kawka, Tamara M. H. Gall, David Cunningham, Long R. Jiao
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the most common malignant pancreatic tumor, often originating from the ducts within the pancreas. This article summarizes the existing evidence on the progression of precancerous lesions to PDAC. Pancreatic intraepithelial lesions were found to be the most common precancerous lesion, leading to approximately 80% of PDAC cases. The lack of characterization of PDAC precursor cystic lesions may result in unnecessary surgeries for patients. Advances in molecular techniques may enable personalized management of pancreatic cancer in the future.
Article
Surgery
Yoshinori Takeda, Hiroshi Imamura, Jiro Yoshimoto, Yuki Fukumura, Ryuji Yoshioka, Yoshihiro Mise, Seiji Kawasaki, Akio Saiura
Summary: The study highlights the clinical entity of T1a invasive intraductal papillary mucinous carcinoma specifically observed in patients with intraductal papillary mucinous carcinoma, associated with excellent postoperative survival outcomes. The survival advantage of invasive intraductal papillary mucinous carcinoma over pancreatic ductal adenocarcinoma is attributed to intrinsic indolent biological behavior, especially in patients without lymphatic invasion or lymph node metastasis.
Article
Oncology
Yan Deng, Bing Ming, Ting Zhou, Jia-long Wu, Yong Chen, Pei Liu, Ju Zhang, Shi-yong Zhang, Tian-wu Chen, Xiao-Ming Zhang
Summary: The study successfully distinguished pancreatic ductal adenocarcinoma and mass-forming chronic pancreatitis using radiomics models based on multiparametric MRI. The results suggest that radiomics models outperform clinical models and radiologists' evaluations in identifying PDAC and MFCP, indicating potential clinical utility.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Valeriya S. Tikhonova, Grigory G. Karmazanovsky, Evvgeny Kondratyev, Ivan S. Gruzdev, Kseniya A. Mikhaylyuk, Mikhail Y. Sinelnikov, Amiran Sh Revishvili
Summary: This study developed a diagnostic radiomic model-based algorithm for predicting the grade of pancreatic ductal adenocarcinoma (PDAC). The results showed that radiomics features vary in PDAC of different grades and increase the accuracy of preoperative CT diagnosis.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amy Makler, Waseem Asghar
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths in the United States, creating a need for sensitive detection methods. Exosomal biomarker panels offer promise for PDAC screening. In this study, a four-marker panel of miRNAs (miR-93-5p, miR-339-3p, miR-425-5p, and miR-425-3p) showed high diagnostic accuracy for PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Amaninder J. Dhaliwal, Banreet S. Dhindsa, Harmeet S. Mashiana, Harlan Sayles, Rajani Rangray, Mohit Girotra, Shailender Singh, Ishfaq Bhat
GASTROINTESTINAL ENDOSCOPY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Amaninder Dhaliwal, Avanija Buddam, Saurabh Chandan, Ishfaq Bhat, Shailender Singh, Harlan Sayles, Derrick Antoniak, Alexander Hewlett, Fedja A. Rochling
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Mohamad I. Mubder, Harmeet Mashiana, Amaninder Dhaliwal, Chad Cross, Banreet Dhindsa, Saurabh Chandan, Mahendran Jayaraj, Gordon Ohning
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Banreet Dhindsa, Mohamad I. Mubder, Amaninder Dhaliwal, Harmeet Mashiana, Jacqueline Choa, Harlan Sayles, Gordon Ohning, Shailender Singh, Ishfaq Bhat, Douglas G. Adler
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Banreet Dhindsa, Amaninder Dhaliwal, Harmeet Mashiana, Jacqueline Choa, Harlan Sayles, Gordon Ohning, Alexander Hewlett, Renee Young, Derrick Eichele
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Banreet Dhindsa, Harmeet Mashiana, Amaninder Dhaliwal, Amaan Shafi, Harlan Sayles, Gordon Ohning, Renee Young, Alexander Hewlett, Derrick Eichele
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Review
Oncology
Vipin Dalal, Joseph Carmicheal, Amaninder Dhaliwal, Maneesh Jain, Sukhwinder Kaur, Surinder K. Batra
Review
Gastroenterology & Hepatology
Banreet Singh Dhindsa, Amaninder Dhaliwal, Babu P. Mohan, Harmeet Singh Mashiana, Mohit Girotra, Shailender Singh, Gordon Ohning, Ishfaq Bhat, Douglas G. Adler
ENDOSCOPY INTERNATIONAL OPEN
(2020)
Review
Gastroenterology & Hepatology
Amaninder Dhaliwal, Sindhura Kolli, Banreet Singh Dhindsa, Harmeet Singh Mashiana, Neil Bhogal, Ishfaq Bhat, Shailender Singh, Douglas G. Adler
ANNALS OF GASTROENTEROLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Amaninder Dhaliwal, Bernie Lamb, Ian Cormier, Harlan Sayles, Derrick Eichele, Renee Young, Alexander Hewlett
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Neil Bhogal, Amaninder Dhaliwal, Elizabeth Lyden, Fedja Rochling, Marco Olivera-Martinez
WORLD JOURNAL OF HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Amaninder Jeet Singh Dhaliwal, Jonathan R. Strosberg, Barbara A. Centeno, Shivakumar Vignesh
ENDOSCOPY INTERNATIONAL OPEN
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Amaninder J. Dhaliwal, Molly Hiatt, Annie Braseth, Harlan Sayles, Renee Young, Derrick Eichelle, Alexander Hewlett
Meeting Abstract
Gastroenterology & Hepatology
Amaninder J. Dhaliwal, Banreet S. Dhindsa, Timothy McCashland, Fedja A. Rochling, Marco Olivera-Martinez