Noncanonical Wnt planar cell polarity signaling in lung development and disease

Loss of Endothelial Derived WNT5A is Associated with Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension

(2019) Ke Yuan et al.   CIRCULATION

Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2019) Alvar Agustí et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fat/Dachsous family cadherins in cell and tissue organisation

(2019) Alexander D. Fulford et al.   CURRENT OPINION IN CELL BIOLOGY

Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity

(2018) Bo Gao et al.   DEVELOPMENT

MYH9: Structure, functions and role of non-muscle myosin IIA in human disease

(2018) Alessandro Pecci et al.   GENE

Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus

(2018) Keishi Kishimoto et al.   Nature Communications

Regulation of human airway epithelial tissue stem cell differentiation by β-catenin, P300, and CBP

(2018) Daniel T. Malleske et al.   STEM CELLS

Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix

(2018) Anna M. Love et al.   DEVELOPMENT

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families

(2017) Oksana Voloshanenko et al.   FASEB JOURNAL

‘WNT-er is coming’ : WNT signalling in chronic lung diseases

(2017) H A Baarsma et al.   THORAX

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

(2016) Hoeke A. Baarsma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration

(2016) Crystal F. Davey et al.   PLoS Genetics

Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis

(2015) Ke Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of lung development and regeneration by the vascular system

(2015) Nicole Woik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt4 is essential to normal mammalian lung development

(2015) Arianna Caprioli et al.   DEVELOPMENTAL BIOLOGY

Multiciliated Cells

(2014) Eric R. Brooks et al.   CURRENT BIOLOGY

Canonical Wnt Signaling Activity in Early Stages of Chick Lung Development

(2014) Rute Silva Moura et al.   PLoS One

Vangl2 Regulates E-Cadherin in Epithelial Cells

(2014) Tadahiro Nagaoka et al.   Scientific Reports

Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

(2014) Simon A. Ramsbottom et al.   PLoS Genetics

Flattop regulates basal body docking and positioning in mono- and multiciliated cells

(2014) Moritz Gegg et al.   eLife

Wntless is required for peripheral lung differentiation and pulmonary vascular development

(2013) Bridget Cornett et al.   DEVELOPMENTAL BIOLOGY

Regulation of Wnt4 in chronic obstructive pulmonary disease

(2013) Andrew L. Durham et al.   FASEB JOURNAL

Regulation of PCP by the Fat signaling pathway

(2013) M. Matis et al.   GENES & DEVELOPMENT

Right Heart Adaptation to Pulmonary Arterial Hypertension

(2013) Anton Vonk-Noordegraaf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila

(2013) Jun Wu et al.   NATURE CELL BIOLOGY

Revisiting planar cell polarity in the inner ear

(2013) Jérôme Ezan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease

(2013) Irene H Heijink et al.   THORAX

Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton

(2013) Cheng Cui et al.   PLOS BIOLOGY

Microtubules Enable the Planar Cell Polarity of Airway Cilia

(2012) Eszter K. Vladar et al.   CURRENT BIOLOGY

Nonmuscle myosin II regulation of lung epithelial morphology

(2012) Erin J. Plosa et al.   DEVELOPMENTAL DYNAMICS

Vertebrate kidney tubules elongate using a planar cell polarity–dependent, rosette-based mechanism of convergent extension

(2012) Soeren S Lienkamp et al.   NATURE GENETICS

Wnt ligands signal in a cooperative manner to promote foregut organogenesis

(2012) M. F. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs

(2012) Kayoko Shimodaira et al.   RESPIRATORY RESEARCH

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans

(2011) Hirotaka Tao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Principles of planar polarity in animal development

(2011) L. V. Goodrich et al.   DEVELOPMENT

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration

(2011) G. S. Walsh et al.   DEVELOPMENT

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

(2011) J. B. Wallingford et al.   GENES & DEVELOPMENT

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear

(2010) Anju Paudyal et al.   BMC DEVELOPMENTAL BIOLOGY

Contribution of VANGL2 mutations to isolated neural tube defects

(2010) Z Kibar et al.   CLINICAL GENETICS

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia

(2010) Boris Guirao et al.   NATURE CELL BIOLOGY

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

(2010) Fadel Tissir et al.   NATURE NEUROSCIENCE

Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis

(2010) Dragana Antic et al.   PLoS One

Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway

(2009) Richard J. B. Francis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The PCP Pathway Instructs the Planar Orientation of Ciliated Cells in the Xenopus Larval Skin

(2009) Brian Mitchell et al.   CURRENT BIOLOGY

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors

(2009) Jean-Remy Courbard et al.   DEVELOPMENTAL BIOLOGY

Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases

(2009) Yasuhiro Minami et al.   DEVELOPMENTAL DYNAMICS

Generation of an allele to inactivateWnt4gene function conditionally in the mouse

(2009) Jingdong Shan et al.   GENESIS

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways

(2009) Vinicio A. de Jesus Perez et al.   JOURNAL OF CELL BIOLOGY

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development

(2009) Ryan S. Gray et al.   NATURE CELL BIOLOGY

Planar Cell Polarity Signaling: The Developing Cell's Compass

(2009) E. K. Vladar et al.   Cold Spring Harbor Perspectives in Biology

The Noncanonical WNT Pathway Is Operative in Idiopathic Pulmonary Arterial Hypertension

(2008) Isabel P. Laumanns et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chick pulmonary Wnt5a directs airway and vascular tubulogenesis

(2008) M. Loscertales et al.   DEVELOPMENT

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

(2008) Sakura Saburi et al.   NATURE GENETICS

Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells

(2008) Tae Joo Park et al.   NATURE GENETICS