Article
Rheumatology
Salman F. Bhai, Mazen M. Dimachkie, Marianne de Visser
Summary: Idiopathic inflammatory myopathies are a group of systemic inflammatory disorders that primarily affect muscle. Accurate diagnosis requires multiple laboratory and pathological evidence due to the wide variation in signs and symptoms. Misdiagnosis is often attributed to overlapping clinical manifestations and limitations of diagnostic tests. Understanding the limitations of tests and recognizing the shared features between inflammatory and noninflammatory myopathies can help avoid misdiagnosis with other similar conditions.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Sangmee Sharon Bae, Ani Shahbazian, Jennifer Wang, Ilana Golub, Buzand Oganesian, Tyler Dowd, Beata Vayngortin, Ryan Wang, David Elashoff, Srinivasa T. Reddy, Christina Charles-Schoeman
Summary: This study found that the activity of PON1 is significantly reduced in patients with IIM compared to healthy controls, and it is inversely associated with disease activity and the presence of severe ILD. The PON1 Q192R polymorphism is strongly linked to the paraoxonase activity of PON1 in IIM, and patients with the PON1 QQ genotype may have better disease outcomes in IIM.
Article
Rheumatology
Maheswari Muruganandam, Ahsan Iqbal, Eyerusalem B. Akpan, Anthony C. Dolomisiewicz, Yvonne M. Waters, N. Suzanne Emil, Sharon E. Nunez, Matthew K. McElwee, Frank X. O'Sullivan, Roderick A. Fields, Wilmer L. Sibbitt
Summary: This study compared the manifestations of immune-mediated necrotizing myopathy (IMNM) to idiopathic inflammatory myositis (IIM) in Native Americans. It found that IMNM patients were older and more likely to have diabetes, hyperlipidemia, and statin exposure. They also had significantly higher levels of creatine kinase and anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibodies, and a higher prevalence of necrotizing myopathy. However, they had shorter disease duration and fewer cutaneous or vascular manifestations compared to IIM patients.
Article
Rheumatology
Renaud Felten, Margherita Giannini, Benoit Nespola, Beatrice Lannes, Dan Levy, Raphaele Seror, Olivier Vittecoq, Eric Hachulla, Aleth Perdriger, Philippe Dieude, Jean-Jacques Dubost, Anne-Laure Fauchais, Veronique Le Guern, Claire Larroche, Emmanuelle Dernis, Dewi Guellec, Divi Cornec, Jean Sibilia, Xavier Mariette, Jacques-Eric Gottenberg, Alain Meyer
Summary: The study aimed to investigate the prevalence, characteristics, and treatment response of myositis in primary SS (pSS) patients. Results revealed that approximately 1% of the 395 pSS patients studied had myositis. Patients with suspected myositis had higher patient-reported scores, while those with confirmed myositis had a longer disease duration.
Article
Rheumatology
Pitcha Chompoopong, Michael P. Skolka, Floranne C. Ernste, Margherita Milone, Teerin Liewluck
Summary: This study investigated the clinical and pathological spectrum of myopathy in sarcoidosis patients and found that sarcoid myopathy is not the only cause of symptomatic myopathy in these patients. IBM is the second most common cause of myopathies in sarcoidosis, and the frequency of IBM in sarcoidosis is higher than in the general population. The study also identified features associated with non-sarcoid myopathies and found that immunosuppressive therapy has limited efficacy in improving symptoms in non-sarcoid myopathy patients. Abnormal MxA expression was observed in some patients, which warrants further research.
Article
Rheumatology
Kristin M. D'Silva, Lingyi Li, Na Lu, Alexis Ogdie, J. Antonio Avina-Zubieta, Hyon K. Choi
Summary: The study aimed to examine recent trends in diabetes mellitus (DM) and polymyositis (PM), finding that the premature mortality gap has not significantly improved in recent years, indicating a need for better therapeutic interventions.
Article
Rehabilitation
Gabrielle Brokamp, Lauren Hurst, Leigh Hartog, Ferdinand Vilson, Jerold Reynolds, Bakri H. Elsheikh, W. David Arnold
Summary: This study retrospectively investigates the frequency and progression of ventilatory muscle dysfunction in patients with inclusion body myositis. It shows a high frequency of ventilatory pump muscle weakness, which is associated with more severe respiratory symptoms. Baseline muscle strength may indicate the risk of respiratory decline, highlighting the importance of pulmonary function surveillance as ventilatory and limb muscle decline may not progress correspondingly.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Aleksandra Halina Opinc, Marcin Adam Makowski, Zuzanna Malgorzata Lukasik, Joanna Samanta Makowska
Summary: This review provides a detailed study of cardiovascular involvement in idiopathic inflammatory myopathies (IIM), indicating that while such involvement is frequent in IIM, it typically remains subclinical with congestive heart failure being the most common symptomatic form. Further research is needed to investigate the development of cardiovascular diseases and the impact of different treatment options.
HEART FAILURE REVIEWS
(2021)
Review
Immunology
Gioia Merlonghi, Giovanni Antonini, Matteo Garibaldi
Summary: IMNMs are a subgroup of idiopathic inflammatory myopathies characterized by severe clinical presentation with specific histopathological features in muscle biopsy. Careful analysis is needed to differentiate IMNMs from other types of myopathies.
AUTOIMMUNITY REVIEWS
(2022)
Article
Geriatrics & Gerontology
Judith Canto-Santos, Laura Valls-Roca, Ester Tobias, Francesc Josep Garcia-Garcia, Mariona Guitart-Mampel, Anna Esteve-Codina, Beatriz Martin-Mur, Mercedes Casado, Rafael Artuch, Estel Solsona-Vilarrasa, Jose Carlos Fernandez-Checa, Carmen Garcia-Ruiz, Carles Rentero, Carlos Enrich, Pedro J. J. Moreno-Lozano, Jose Cesar Milisenda, Francesc Cardellach, Josep M. M. Grau-Junyent, Gloria Garrabou
Summary: In this study, molecular disturbances were found in fibroblast samples from IBM patients, including abnormal gene expression related to inflammation, mitochondria, and cell cycle regulation, as well as functional changes in inflammatory, autophagy, mitochondrial, and metabolic processes. These findings contribute to a better understanding of the pathogenesis of IBM and provide insights for the identification of new biomarkers and therapeutic strategies.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Medical Laboratory Technology
Konstantinos I. Tsamis, Constantinos Boutsoras, Evripidis Kaltsonoudis, Eleftherios Pelechas, Ilias P. Nikas, Yannis V. Simos, Paraskevi V. Voulgari, Ioannis Sarmas
Summary: Idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders primarily affecting muscles, but other organs can also be involved. Recent updates in diagnostic approach, utilizing circulating autoantibodies, have improved patient management.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Rheumatology
J. C. Milisenda, I Pinal-Fernandez, T. E. Lloyd, J. M. Grau, F. W. Miller, A. Selva-O'Callaghan, L. Christopher-Stine, W. Stenzel, A. L. Mammen, A. M. Corse
Summary: The accumulation of p62 in muscle biopsies is a general response to muscle injury, not specific to sIBM. In sIBM, levels of p62 RNA are decreased, indicating that p62 aggregation in this disease is not due to overexpression.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Review
Clinical Neurology
Chen-Hua Wang, Wen-Chen Liang
Summary: Immune-mediated necrotizing myopathy (IMNM) is a rare inflammatory myopathy in children, causing severe muscle weakness and often unresponsive to corticosteroids alone. Delayed diagnosis is common due to the similarity between IMNM and inherited myopathy. Raising awareness about pediatric IMNM can lead to early diagnosis and effective treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Boel De Paepe, Ken R. Bracke, Jan L. De Bleecker
Summary: This retrospective study explores the potential of novel blood-based biomarkers CXCL10 and GDF15 in myositis patients and finds their effectiveness and relevance in diagnosis. The study suggests adding CXCL10 and GDF15 to the blood-based diagnostic toolkit for myositis.
Review
Immunology
Nestor Lopez Guerra, Ana Matas-Garcia, Laura Serra-Garcia, Daniel Morgado-Carrasco, Joan Padrosa, Iban Aldecoa, Yaiza Duque, Maria Casal-Dominguez, Sandra Munoz-Braceras, Raquel Aranega, Pedro Moreno-Lozano, Judith Canto-Santos, Gloria Garrabou, Estibaliz Ruiz-Ortiz, Ernesto Trallero-Araguas, Albert Selva-O'Callaghan, Josep M. Grau, Susana Puig, Jiram Torres-Ruiz, Andrew L. Mammen, Iago Pinal Fernandez, Jose C. Milisenda
Summary: This study aims to describe three cases of dermatomyositis (DM) triggered by immune checkpoint inhibitors (ICI) and perform a review of the literature. The study found that ICI can trigger DM and lead to different immune-related adverse events. The retrospective evaluation of the three cases suggests that early positivity to anti-TIF1 γ may play a role in the development of DM.
AUTOIMMUNITY REVIEWS
(2023)
