Article
Immunology
Xizi Yang, Ziyu He, Ruizhi Hu, Jiahao Yan, Qianjin Zhang, Baizhen Li, Xupeng Yuan, Hongfu Zhang, Jianhua He, Shusong Wu
Summary: Dietary supplementation of beta-carotene can contribute to postpartum uterine recovery by reducing postpartum uterine hemorrhage and inhibiting the production of inflammatory cytokines potentially through modulating gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Daniela Karasova, Magdalena Crhanova, Vladimir Babak, Martin Jerabek, Lubos Brzobohaty, Zuzana Matesova, Ivan Rychlik
Summary: The study revealed that certain microbial populations before weaning may increase the risk of piglets developing diarrhea, while other microbial populations after weaning may enhance piglet health and disease resistance. Therefore, changes in microbiota before and after weaning are crucial for piglet resistance to postweaning diarrhea under field conditions.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Erin Oi-Yan Wong, Emma Joan Elizabeth Brownlie, Katharine Michelle Ng, Sornnujah Kathirgamanathan, Feiqiao Brian Yu, Bryan D. Merrill, Kerwyn Casey Huang, Alberto Martin, Carolina Tropini, William Wiley Navarre
Summary: The microbiota's role in animal physiology has been extensively studied in humans, but there is a lack of isolated lab mouse-associated bacteria. Gut inflammation affects commensal gut microbes and can lead to long-term changes in microbiota composition. To address this, the Collection of Inflammation-Associated Mouse Intestinal Bacteria (CIAMIB) was created, providing a diverse range of isolates, including many previously uncultivated species. This collection allows for the study of host-microbiota interactions.
Review
Food Science & Technology
Xin-Yu Li, Lei Meng, Liang Shen, Hong-Fang Ji
Summary: Vitamin C (VC), vitamin E (VE), and beta-carotene (beta C) are dietary antioxidants that can enhance the body's antioxidant capacity. Their effects on the gut microbiota were reviewed in this article, with 19 studies included. VC, VE, and beta C can modulate the composition and activity of the gut microbiota, improve intestinal barrier function, and support the normal function of the immune system, providing health benefits to the host. Future studies should further investigate the antioxidant activity of vitamins on the gut microbiota and explore the causal relationships between vitamin regulation of the gut microbiota and host health.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Furong Huang, Xiujie Liu, Sheng Xu, Sitao Hu, Sisi Wang, Dibang Shi, Kaicheng Wang, Zhongxiang Wang, Qiongqiong Lin, Shan Li, Siyuan Zhao, KeKe Jin, Chuang Wang, Lei Chen, Fangyan Wang
Summary: The study demonstrates that P. histicola can alleviate estrogen deficiency-induced depression by improving intestinal microbiota, repairing intestinal damage, and inhibiting central inflammation.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yerin Kim, Sunil Jung, Gwoncheol Park, Hakdong Shin, Seung Chul Heo, Yuri Kim
Summary: This study found that beta-carotene supplementation can inhibit cancer cachexia-related changes, including decreased carcass weight, adipose weight, and muscle weight. Additionally, it can suppress cancer cachexia-induced lipolysis, fat browning, hepatic gluconeogenesis, and systemic inflammation. Beta-carotene treatments can also reverse the down-regulated adipogenesis and dysregulated mitochondrial respiration and glycolysis in adipocytes and colon cancer organoid co-culture systems.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Microbiology
Renzhao Lin, Chanping Zhi, Yalin Su, Jiaxin Chen, Debao Gao, Sihan Li, Dayou Shi
Summary: Immunosuppression increases the susceptibility of animals to diseases and disrupts intestinal flora balance, posing a threat to farming industry. This study examined the impact of Echinacea extract (EE) on gut microbiota in immunosuppressed ducks using 16s-RNA sequencing. The results showed that EE significantly improved weight gain, immune organ index, and levels of TNF-alpha, IFN-gamma, and IL-2. The EE group exhibited a closer trend to the healthy group in terms of microbiota diversity. Echinacea extract enhanced intestinal immune function by increasing the abundance of beneficial bacterial genera in the ducks' intestine.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Furong Huang, Hao Pan, Zenglin Tan, Lei Chen, Ting Li, Yangbo Liu
Summary: Wear particles from joint replacements cause chronic osteolysis due to inflammation, which leads to implant failure. Recent studies have shown that the gut microbiota plays a role in modulating metabolism and the immune system, affecting bone mass. Treatment with P. histicola reduces osteolysis in titanium-treated mice by improving the gut microbiota, reducing systemic and local inflammation, and inhibiting bone resorption. These findings suggest that P. histicola may be therapeutically beneficial for particle-induced osteolysis.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Microbiology
Miwei Lv, Jiawei Zhang, Jiaxin Deng, Jiancong Hu, Qinghua Zhong, Mingli Su, Dezheng Lin, Tian Xu, Xuhao Bai, Juan Li, Xuefeng Guo
Summary: This study aimed to analyze the differences in gut microbiome composition between adenoma and control populations. The results showed that Prevotella enterotype was only present in the adenoma group and was an independent risk factor for colorectal adenoma.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Min-Jin Kwak, Sun-Woo Choi, Yong-Soon Choi, Hanbae Lee, Kwang-Youn Whang
Summary: This study demonstrates that adding appropriate SPL supplementation in early-weaned piglets can improve growth performance, histological indices, and gene expression levels related to mucin secretion and local inflammation. Furthermore, SPL supplementation increases the population of beneficial bacteria Prevotella and its short-chain fatty acid production, leading to a reduced occurrence of diarrhea in piglets after weaning.
BMC VETERINARY RESEARCH
(2022)
Article
Genetics & Heredity
Wenjie Ma, Long H. Nguyen, Mingyang Song, Dong D. Wang, Eric A. Franzosa, Yin Cao, Amit Joshi, David A. Drew, Raaj Mehta, Kerry L. Ivey, Lisa L. Strate, Edward L. Giovannucci, Jacques Izard, Wendy Garrett, Eric B. Rimm, Curtis Huttenhower, Andrew T. Chan
Summary: A higher intake of dietary fiber is associated with a decreased risk of chronic inflammatory diseases by altering gut microbiome composition and mitigating systemic inflammation. Specific gut microbial configurations correspond with higher levels of C-reactive protein.
Article
Obstetrics & Gynecology
Yajing Wei, Hao Tan, Ruyu Yang, Fan Yang, Duo Liu, Biqi Huang, Linglong Ouyang, Shuntian Lei, Zehai Wang, Shaoru Jiang, Heng Cai, Xiaofei Xie, Shuzhong Yao, Yanchun Liang
Summary: This study explored the role of gut dysbiosis-derived beta-glucuronidase (GUSB) in the development of endometriosis. By sequencing stool samples from women with and without endometriosis, as well as a mouse model, it was found that beta-glucuronidase had higher expression in bowel lesions and uterosacral ligament lesions. Experimental results showed that beta-glucuronidase promoted the development of endometriosis, possibly by causing macrophage dysfunction.
FERTILITY AND STERILITY
(2023)
Review
Agriculture, Dairy & Animal Science
Fatemeh Balouei, Bruno Stefanon, Sandy Sgorlon, Misa Sandri
Summary: This review paper provides a recent perspective on the gut microbiome of newborn puppies. It suggests that microbial colonization of newborns begins at birth and can be influenced by various factors such as parturition, maternal microbiota, and diet. The maternal microbiota and diet are particularly important for the development and growth of puppies' gut microbiota.
Article
Biochemistry & Molecular Biology
Zhengzhong Luo, Li Ma, Tao Zhou, Yixin Huang, Liben Zhang, Zhenlong Du, Kang Yong, Xueping Yao, Liuhong Shen, Shumin Yu, Xiaodong Shi, Suizhong Cao
Summary: This study aimed to evaluate the effects of 13-glucan (BG) supplementation on gut microbiome and plasma metabolites of dairy calves. The results showed that BG promoted growth and health of pre-weaning dairy calves by affecting the interaction between the host and gut microbiota.
Review
Food Science & Technology
Manuel Bernabeu, Seyed Mohammad Taghi Gharibzahedi, Arsheed A. Ganaie, Muzafar A. Macha, Basharat N. Dar, Juan M. Castagnini, Cristina Garcia-Bonillo, Antonio J. Melendez-Martinez, Zeynep Altintas, Francisco J. Barba
Summary: Gut microbiota plays a crucial role in immune checkpoint therapy, and carotenoids can modulate the microbiome effectively to reduce chronic disease risks. This review focuses on the bio-functional effects of carotenoids on gut microbiota and utilizes the PRISMA methodology to analyze papers published in the past two decades. The results show that carotenoids can lead to quantitative changes in intestinal bacteria, and their modulation of gut microbiota promotes the appearance of beneficial bacteria and protects the intestinal epithelium.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Wuying Lang, Pan Hong, Ruonan Li, Hao Zhang, Yusheng Huang, Xin Zheng
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2019)
Article
Cell Biology
Ruonan Li, Junnan Hui, Gan Luo, Pan Hong, Lingqian Li, Yu Yang, Xin Zheng, Hainan Lan
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
Ruonan Li, Yu Yang, Pan Hong, Ziqi Zhang, Lingqian Li, Junnan Hui, Xin Zheng
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2020)
Article
Endocrinology & Metabolism
Ruonan Li, Yu Yang, Hainan Lan, Yuesi Wang, Zihan Ge, Xingjie Liu, Yixuan Zhou, Wei Zhang, Li Xian, Hongxuan Yuan
Summary: Prolactin and its receptor play important roles in breast cancer. A receptor antagonist, hPRL-G129R, has been found to have dual functions by inhibiting intracellular signaling and blocking nuclear localization of the receptor. In vitro and in vivo experiments showed that hPRL-G129R can inhibit the proliferation and migration of breast cancer cells. These findings lay a foundation for the development of effective drugs against breast malignancies.