Article
Biochemistry & Molecular Biology
Kailing Xu, Jie Ma, Chuan Li, Chuangjun Li, Yingda Zang, Xingyan Sun, Xiaoguang Chen, Xiaoliang Wang, Dongming Zhang
Summary: Six pairs of enantiomeric obovatol dimeric neolignans were isolated from the bark of Magnolia officinalis var. biloba, with one enantiomer showing cytotoxic activity against human cancer cell lines and two others exhibiting neuroprotective effects on glutamic acid-induced cellular damage.
Article
Plant Sciences
Xi-Lan Jiang, Yu-Jiao He, Xiao-Yu Hou, Bin-Bin Yang, Lun Wang, Fu Li, Bin Chen, Aftab Yaseen, Ming-Kui Wang
Summary: Chemical investigation of Paris polyphylla smith var. yunnanensis led to the discovery of two new polyhydroxylated steroidal glycosides, named Parisyunnanosides K and L (1-2), along with nine known compounds. The new compounds, Parisyunnanosides K and L (1-2), are rare C-27 steroidal glycosides. Furthermore, cytotoxic activity evaluation revealed that compounds 5-11 exhibited potent cytotoxic activity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Food Science & Technology
Silvie Rimpelova, Tomas Zimmermann, Pavel B. Drasar, Bohumil Dolensky, Jiri Bejcek, Eva Kmonickova, Petra Cihlarova, Sona Gurska, Lucie Kuklikova, Marian Hajduch, Tomas Ruml, Lubomir Opletal, Petr Dzubak, Michal Jurasek
Summary: Cardiac glycosides (CGs) are a diverse group of natural compounds, with most being potent inhibitors of Na+/K+-ATPase used in treating cardiac conditions. Some lesser known CGs may have anticancer potential, but currently used CGs have limitations in cancer treatment. This study focused on two poorly described CGs, hyrcanoside and deglucohyrcanoside, with the hope of them serving as research tools and novel cancer therapeutics.