TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates

Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism

(2019) Rajesh K. Singh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

(2017) Rajesh K. Singh et al.   JOURNAL OF LIPID RESEARCH

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

(2017) Xunde Xian et al.   eLife

Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse

(2016) Rajesh K. Singh et al.   JOURNAL OF CELL SCIENCE

Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells

(2016) Nien-Cheng Chen et al.   Scientific Reports

PI3K isoform-selective inhibitors: next-generation targeted cancer therapies

(2015) Xiang Wang et al.   ACTA PHARMACOLOGICA SINICA

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell FormationSignificance

(2015) Abigail S. Haka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TLR4/NF-κB Signaling Contributes to Chronic Unpredictable Mild Stress-Induced Atherosclerosis in ApoE-/- Mice

(2015) Ya Ling Tang et al.   PLoS One

The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice

(2014) Dávid Győri et al.   Arthritis & Rheumatology

Plasmin Promotes Foam Cell Formation by Increasing Macrophage Catabolism of Aggregated Low-Density Lipoprotein

(2013) Abigail S. Haka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis

(2013) Anna M. Lundberg et al.   CARDIOVASCULAR RESEARCH

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages

(2013) Soo-Ho Choi et al.   PLoS One

The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice

(2012) M Rachel Richards et al.   Innate Immunity

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Class B Scavenger Receptor Types I and II and CD36 Mediate Bacterial Recognition and Proinflammatory Signaling Induced by Escherichia coli, Lipopolysaccharide, and Cytosolic Chaperonin 60

(2011) I. N. Baranova et al.   JOURNAL OF IMMUNOLOGY

Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice

(2010) Mie Higashimori et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aggregated LDL in Contact With Macrophages Induces Local Increases in Free Cholesterol Levels That Regulate Local Actin Polymerization

(2009) Inna Grosheva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4–Dependent Fluid Phase Uptake

(2009) Soo-Ho Choi et al.   CIRCULATION RESEARCH

Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

(2009) Yu Sun et al.   CIRCULATION RESEARCH

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

(2009) Konstantin Stoletov et al.   CIRCULATION RESEARCH

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

(2009) Abigail S. Haka et al.   MOLECULAR BIOLOGY OF THE CELL

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Acid Sphingomyelinase Promotes Lipoprotein Retention Within Early Atheromata and Accelerates Lesion Progression

(2008) Cecilia M. Devlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH