Article
Microbiology
Kati Karvonen, Jonna Nykky, Varpu Marjomaeki, Leona Gilbert
Summary: The study investigated the infection processes of B. burgdorferi in two human cell lines, revealing differences in infection patterns, dose-dependent responses, and morphological variations between the cell lines. The findings suggest a mechanism of immune evasion for the bacteria through invading non-phagocytic cells and lack of cytopathic effects onto the host cells.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Felipe C. Cabello, Monica E. Embers, Stuart A. Newman, Henry P. Godfrey
Summary: Lyme disease is caused by tick-transmitted Borreliella burgdorferi, with an estimated annual incidence of at least 476,000 cases in the United States. 10% to 20% of patients treated with antimicrobial drugs may develop posttreatment Lyme disease syndrome (PTLDS), the etiology and pathogenesis of which remain uncertain.
Article
Microbiology
Paul M. Arnaboldi, Adiya S. Katseff, Mariya Sambir, Raymond J. Dattwyler
Summary: This study evaluated the efficacy of using synthetic peptides containing unique epitopes from B. burgdorferi as antigen targets in Lyme disease seroassay. The results showed that combining epitopes from different antigens significantly increased the sensitivity of the assay without compromising specificity. These findings provide a new approach to improve the laboratory diagnosis of Lyme disease.
Review
Microbiology
Yonathan Arfi, Carole Lartigue, Pascal Sirand-Pugnet, Alain Blanchard
Summary: Mycoplasmas are small, genome-reduced bacteria with the ability to colonize a wide range of host species. They can exist as commensal microbiota or cause pathogenic inflammatory diseases. These bacteria have evolved strategies to evade the host's immune response, including the expression of immunoglobulin-binding proteins to prevent antibody-antigen interaction. Understanding these immune evasion mechanisms is crucial for studying mycoplasma diseases and improving vaccine efficacy.
Article
Medicine, General & Internal
Iwona Wojciechowska-Koszko, Magdalena Mnichowska-Polanowska, Pawel Kwiatkowski, Paulina Roszkowska, Monika Sienkiewicz, Barbara Dolegowska
Summary: The study investigated the immunoreactivity of LD patient sera to Borrelia antigens using an ELISA-IB assay combination. More positive results were obtained in the IgM class in the ELISA assay, while positive results dominated in the IgG class in the IB assay. Positive results in the IB assay most often showed IgM antibodies against specific antigens like OspC and flagellin, and IgG antibodies against antigens like VlsE, BmpA, OspC, p41, and p83.
Article
Immunology
Bijaya Sharma, Julie E. McCarthy, Cecily A. Freliech, Morgen M. Clark, Linden T. Hu
Summary: Unrecognized immunodeficiency may contribute to antibiotics' failure in treating Lyme disease symptoms. The study showed that the efficacy of doxycycline was significantly lower in mice lacking adaptive immunity, especially B cells, with the most pronounced effect seen in immunodeficient C3H mice. Additionally, the addition of a single dose of ceftriaxone to doxycycline treatment effectively cleared infection in severely immunodeficient C3H mice.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Shelby D. Foor, Kalvis Brangulis, Anil K. Shakya, Vipin S. Rana, Sandhya Bista, Chrysoula Kitsou, Michael Ronzetti, Adit B. Alreja, Sara B. Linden, Amanda S. Altieri, Bolormaa Baljinnyam, Inara Akopjana, Daniel C. Nelson, Anton Simeonov, Osnat Herzberg, Melissa J. Caimano, Utpal Pal
Summary: BB0238 protein plays a crucial role in the pathogenesis of Lyme disease by interacting with multiple B. burgdorferi proteins and facilitating the transmission of the pathogen from ticks to mice. The structure and function of BB0238 have been investigated, providing insights into the biology of B. burgdorferi and potential targets for prevention strategies against tick-borne infections.
Review
Microbiology
Cassidy Anderson, Catherine A. Brissette
Summary: Lyme disease caused by Borrelia burgdorferi sensu lato is the most common vector-borne illness in the northern hemisphere. The pathogen is capable of establishing a persistent infection within the host by utilizing various immune evasion tactics. Understanding these methods can provide insights into the pathogenesis of B. burgdorferi and Lyme disease, as well as guide the development of novel and effective treatments.
Article
Microbiology
Maroun M. Sfeir, Jennifer K. Meece, Elitza S. Theel, Dane Granger, Thomas R. Fritsche, Allen C. Steere, John A. Branda
Summary: Modified two-tiered testing algorithms are acceptable alternatives for Lyme disease diagnosis. The study found that these algorithms showed higher sensitivity in patients with acute erythema migrans and comparable specificity in other types of Lyme disease patients and control subjects.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Clinical Neurology
Anne Marit Solheim, Aslaug Rudjord Lorentzen, Audun Olav Dahlberg, Heidi Oyen Flemmen, Synne Brune, Kristine Johanne Nordstrom Forselv, Are Hugo Pripp, Margrete Halvorsen Bo, Randi Eikeland, Harald Reiso, Ase Mygland, Unn Ljostad
Summary: This study compared the efficacy and safety of oral doxycycline for 2 and 6 weeks in European Lyme neuroborreliosis (LNB). The results indicated that there were no benefits of doxycycline treatment beyond 2 weeks in European LNB.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Immunology
Jessica K. Wong, Michael A. Crowley, Troy Bankhead
Summary: This study found that the bbd21 gene and the bbd22 gene are co-transcribed and play an important role in regulating the copy number of the lp17 plasmid. After in vitro passaging, the mutant strain with bbd21 and bbd22 deletion showed a significant increase in lp17 copy number. Under mammalian host-adapted cultivation, the absence of bbd21-bbd22 resulted in significantly decreased copies of lp17 and decreased tissue colonization ability in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Bryna L. Fitzgerald, Barbara Graham, Mark J. Delorey, Adoracion Pegalajar-Jurado, M. Nurul Islam, Gary P. Wormser, John N. Aucott, Alison W. Rebman, Mark J. Soloski, John T. Belisle, Claudia R. Molins
Summary: This study used metabolomics to analyze metabolic responses in patients with Post-treatment Lyme disease symptoms/syndrome (PTLDS) compared to clinically cured non-PTLDS patients. The findings revealed observable metabolic differences between PTLDS and non-PTLDS patients at multiple time points, with distinct patterns of metabolite abundance. A small number of metabolites could be used to define PTLDS versus non-PTLDS patients at specific time points, and these findings were validated in a second patient cohort. These results suggest that metabolite-based measurement can help distinguish patients with PTLDS and provide insights into the underlying biochemistry of PTLDS.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Shaghayegh Jahanbani, Paige S. Hansen, Lisa K. Blum, Effie E. Bastounis, Nitya S. Ramadoss, Mallesh Pandrala, Jessica Marie Kirschmann, Grace Sisemore Blacker, Zelda Z. Love, Irving L. Weissman, Fahimeh Nemati, Michal Caspi Tal, William H. Robinson
Summary: This study sequenced the antibody repertoire of plasmablasts in Bb-infected humans and identified their binding specificities. The researchers found that by conjugating a TLR9-agonist CpG oligo to an anti-BmpA monoclonal antibody, they were able to enhance macrophage phagocytosis of Bb.
CLINICAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
Elisa Kortela, Mari Kanerva, Satu Kurkela, Jarmo Oksi, Asko Jarvinen
Summary: This study evaluated the conditions behind the symptoms in patients with suspected Lyme borreliosis (LB) referred to an infectious diseases clinic. The results showed that LB was unlikely in half of the patients, with most cases having other conditions to explain their symptoms.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Health Care Sciences & Services
Finja Huendersen, Stefanie Forst, Erich Kasten
Summary: The study found that patients with Lyme disease have lower quality of life and sleep, as well as cognitive impairments in attention and memory. Depressive symptoms are common among Lyme patients, and the disease is often diagnosed late.
Article
Biotechnology & Applied Microbiology
Timothy Casselli, Troy Bankhead
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY
(2015)
Article
Multidisciplinary Sciences
Allison E. James, Artem S. Rogovskyy, Michael A. Crowley, Troy Bankhead
Article
Microbiology
Allison E. James, Artem S. Rogovskyy, Michael A. Crowley, Troy Bankhead
Review
Cell Biology
Guy H. Palmer, Troy Bankhead, Sheila A. Lukehart
CELLULAR MICROBIOLOGY
(2009)
Article
Immunology
Timothy Casselli, Yvonne Tourand, Troy Bankhead
INFECTION AND IMMUNITY
(2012)
Article
Immunology
Petronella R. Hove, Gary J. Haldorson, Forgivemore Magunda, Troy Bankhead
INFECTION AND IMMUNITY
(2014)
Article
Immunology
Artem S. Rogovskyy, Troy Bankhead
INFECTION AND IMMUNITY
(2014)
Article
Multidisciplinary Sciences
Artem S. Rogovskyy, Troy Bankhead
Article
Multidisciplinary Sciences
Artem S. Rogovskyy, Timothy Casselli, Yvonne Tourand, Cami R. Jones, Jeb P. Owen, Kathleen L. Mason, Glen A. Scoles, Troy Bankhead
Article
Microbiology
Artem S. Rogoyskyy, Zigui Chen, Robert D. Burk, Troy Bankhead
VETERINARY MICROBIOLOGY
(2014)
Article
Cell Biology
Timothy Casselli, Michael A. Crowley, Margaret A. Highland, Yvonne Tourand, Troy Bankhead
CELLULAR MICROBIOLOGY
(2019)
Article
Cell Biology
Abdul G. Lone, Troy Bankhead
Article
Immunology
Jessica K. Wong, Michael A. Crowley, Troy Bankhead
Summary: This study found that the bbd21 gene and the bbd22 gene are co-transcribed and play an important role in regulating the copy number of the lp17 plasmid. After in vitro passaging, the mutant strain with bbd21 and bbd22 deletion showed a significant increase in lp17 copy number. Under mammalian host-adapted cultivation, the absence of bbd21-bbd22 resulted in significantly decreased copies of lp17 and decreased tissue colonization ability in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Guy H. Palmer, Troy Bankhead, H. Steven Seifert
MICROBIOLOGY SPECTRUM
(2016)