Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Oncology
Da Qin, Qingdong Guo, Rui Wei, Si Liu, Shengtao Zhu, Shutian Zhang, Li Min
Summary: This study proposed a new algorithm to quantitate plasma miRNA for colon cancer diagnosis. By establishing a miRNA-pair matrix and using various algorithms, a 4-miRNA pair model was successfully developed that showed good performance in differentiating CC from normal controls.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Dan Cheng, Jing Wang, Zigang Dong, Xiang Li
Summary: Noncoding RNAs, including circRNAs, play an important role in various diseases, and their potential as biomarkers for cancer prognosis and diagnosis is discussed. The features, classification, and analysis methods of circRNAs are also summarized in this review.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Jiafeng Wang, Yulan Zhou, Yixia Yang, Xiang Gao, Zhibin Liu, Guanhao Hong, Lifen Yao, Jingwen Yin, Xuefeng Gu, Keshen Li
Summary: The study found an association between the rs9722 polymorphism of the S100B gene and genetic susceptibility to Alzheimer's disease, with individuals carrying the rs9722 AA genotype having a higher risk. Further investigation suggested that the rs9722 genotype may affect S100B expression levels by altering miRNA binding capacity, potentially increasing the risk of Alzheimer's disease.
Article
Immunology
Lu Han, Shiyun Chen, Zhe Luan, Mengjiao Fan, Yanrong Wang, Gang Sun, Guanghai Dai
Summary: Colon cancer is a complex disease involving interactions between cancer cells and the immune microenvironment. Recent studies have shown that microRNAs (miRNAs) play a critical role in gene regulation in colon cancer, particularly in modulating the immune microenvironment. Identifying miRNAs associated with colon cancer and their regulation of immune function-related genes could provide insights into prognosis and guide personalized treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Tzitzijanik Madrigal, Jesus Hernandez-Monge, Luis A. Herrera, Claudia Haydee Gonzalez-De la Rosa, Guadalupe Dominguez-Gomez, Myrna Candelaria, Fernando Luna-Maldonado, Karla G. Calderon Gonzalez, Jose Diaz-Chavez
Summary: Mutations in the DNA-binding domain of p53 can give rise to different variants with new functions, known as Gain-of-function p53 mutants. Recent studies have shown that p53 mutants regulate gene expression by unbalancing specific microRNAs levels, affecting cellular processes such as epithelial-mesenchymal transition, chemoresistance, and cell survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jiashu Huang, Shenghao Yu, Lei Ding, Lingyuan Ma, Hongjian Chen, Hui Zhou, Yayan Zou, Min Yu, Jie Lin, Qinghua Cui
Summary: Breast cancer and colon cancer, the two deadliest cancers in the world, share similar genetic backgrounds and regulatory genes. Current treatment measures have suboptimal outcomes, so there is a need for innovation. Studies suggest that circRNAs as miRNA sponges play important roles in malignant behaviors of BC and CRC.
Article
Biochemistry & Molecular Biology
Susanta Chatterjee, Ishita Mukherjee, Shreya Bhattacharjee, Mainak Bose, Saikat Chakrabarti, Suvendra N. Bhattacharyya
Summary: In activated macrophages, miR-146a-5p acts as a primary miRNA that coordinates the biogenesis of secondary miRNAs, such as miR-125b, miR-21, or miR-142-3p, to balance immune responses. The coordinated biogenesis of miRNAs is also observed in different cell types.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Genetics & Heredity
Zhiwen Wang, Xi Zhu, Hongyun Zhai, Yanghai Wang, Gangyue Hao
Summary: The study identified and established an mRNA-SNP-miRNA interaction network in prostate cancer, suggesting that hsa-miR-21, hsa-miR-30b, and ITGB8 may serve as new biomarkers. A nomogram model containing four variables was constructed for predicting the risk of prostate cancer.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Paul A. A. Vallejos, Amber Gonda, Jingjing Yu, Brittany G. G. Sullivan, Arsha Ostowari, Mei Li Kwong, Audrey Choi, Matthew J. J. Selleck, Janviere Kabagwira, Ryan N. N. Fuller, Daniel J. J. Gironda, Edward A. A. Levine, Christopher C. W. Hughes, Nathan R. R. Wall, Lance D. D. Miller, Maheswari Senthil
Summary: In this study, a gene signature of 445 genes (ExoSig445) was identified from the RNA sequencing analysis of plasma exosomes, which can robustly discriminate colon cancer patients, including those with PC, from healthy controls. Furthermore, 58 of these exosomal DEGs were found to be overexpressed in colon tumors. These findings suggest that plasma exosomal RNAs can be developed as a highly sensitive liquid biopsy test in colon cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Gang Zhao, Qijing Wang, Yue Zhang, Rui Gu, Min Liu, Qin Li, Jie Zhang, Hang Yuan, Tianyu Feng, Deqiong Ou, Siqi Li, Shan Li, Kai Li, Chunfen Mo, Ping Lin
Summary: This study found that DEAD box helicase 17 (DDX17) is involved in the initiation and development of colorectal cancer (CRC) and is associated with aggressive phenotypes and poor prognosis in CRC patients. DDX17 promotes CRC cell migration and epithelial to mesenchymal transition (EMT) by downregulating miR-149-3p, leading to increased expression of CYBRD1. These findings reveal a novel mechanism of DDX17-mediated CRC metastasis and EMT through the miR-149-3p/CYBRD1 pathway.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Damian A. Cambiagno, Axel J. Giudicatti, Agustin L. Arce, Delfina Gagliardi, Lei Li, Wei Yuan, Derek S. Lundberg, Detlef Weigel, Pablo A. Manavella
Summary: Studies have shown that HST plays a crucial role in the miRNA pathway in Arabidopsis by facilitating the stability of the DCL1-MED37 complex, thereby regulating the transcription and processing of primary miRNAs.
Article
Biochemistry & Molecular Biology
Seung Jun Park, Suk Won Choi, Gu Min Kim, Christian Moller, Hyun-Sook Pai, Seong Wook Yang
Summary: This study identifies forkhead-associated domain 2 (FHA2) as a light-stabilized suppressor of miRNA biogenesis, which interacts with core microprocessors to inhibit pri-miRNA processing activity and fine-tune miRNA processing during de-etiolation in plants.
Article
Medicine, Research & Experimental
Ying Gao, Jie Zhang, Jiexia Pan, Sanjun Ying, Bang Lou, Qingliang Yang, Weiyong Hong, Gensheng Yang
Summary: The aim of this study is to establish a FOF1-ATP synthase molecular motor biosensor for accurate identification of colon cancer miRNAs. The FOF1-ATP synthase molecular motor was extracted and connected to the colon cancer-specific miR-17 capture probe. Signal probes were designed for dual-signal characterization to increase detection accuracy. The FOF1-ATPase rotation rate decreases when the signaling and capture probes combine with the target miRNA, resulting in a decrease in ATP synthesis.
Review
Plant Sciences
Ning Ding, Bailong Zhang
Summary: In plants, microRNAs (miRNAs) play a role in repressing target gene expression at the post-transcriptional level. They are transcribed by DNA-dependent RNA polymerase II and processed into 21 to 22 nucleotide long sequences. Recent studies have highlighted the interconnectedness and dynamic regulation of miRNA biogenesis. This article summarizes the current understanding of miRNA biogenesis, including gene transcription, pri-miRNA processing, AGO1 loading, nuclear export, as well as miRNA metabolism. It emphasizes the importance of linking different steps and subcellular regulation in plant miRNA biogenesis and function.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Jue-Sheng Ong, Jiyuan An, Xikun Han, Matthew H. Law, Priyanka Nandakumar, Johannes Schumacher, Ines Gockel, Anne Bohmer, Janusz Jankowski, Claire Palles, Catherine M. Olsen, Rachel E. Neale, Rebecca Fitzgerald, Aaron P. Thrift, Thomas L. Vaughan, Matthew F. Buas, David A. Hinds, Puya Gharahkhani, Bradley J. Kendall, Stuart MacGregor
Summary: Researchers identified numerous novel risk loci for GERD and BE using a multitrait GWAS model, providing strong evidence for a genetic basis of disease heterogeneity in GERD. They showed that GERD loci associated with obesity are better predictors of BE/EA compared to those associated with depressive symptoms.
Article
Biochemistry & Molecular Biology
Jianhong Chen, Mourad Wagdy Ali, Li Yan, Shruti G. Dighe, James Y. Dai, Thomas L. Vaughan, Graham Casey, Matthew F. Buas
Summary: This study developed an informatics pipeline to prioritize candidate functional variants in GWAS loci for esophageal adenocarcinoma (EAC), leading to the identification of a functional variant and candidate risk enhancer at chr19p13.11. Experimental validation showed allele-specific enhancer activity and correlation with altered expression of genes CRTC1 and COMP, suggesting their potential role as gene targets in BE/EAC risk association.
HUMAN MOLECULAR GENETICS
(2022)
Article
Medicine, General & Internal
Zachary A. Marcum, Jordana B. Cohen, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: The use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors is associated with a lower risk of dementia. This study examines the impact of exclusively stimulating vs inhibiting antihypertensive medication regimens on mild cognitive impairment (MCI) or dementia. The findings suggest that prevalent users of stimulating medications had lower rates of cognitive impairment.
Article
Cardiac & Cardiovascular Systems
Aubrey E. Jones, Madeleine M. McCarty, Juan P. Brito, Peter A. Noseworthy, Kerri L. Cavanaugh, Kenzie A. Cameron, Geoffrey D. Barnes, Benjamin A. Steinberg, Daniel M. Witt, George H. Crossley, Rod Passman, Preeti Kansal, Ian Hargraves, Monika Schmidt, Elizabeth Jackson, Adriana Guzman, Anthony Ariotti, Mandy L. Pershing, Jennifer Herrick, Victor M. Montori, Angela Fagerlin, Elissa M. Ozanne
Summary: This study aims to compare the effectiveness of patient decision aid (PDA) and encounter decision aid (EDA) in shared decision making. The study will recruit atrial fibrillation (AF) patients and their managing clinicians for stroke prevention strategies in a randomized controlled trial. The results will contribute to improving AF outcomes and patient experiences with stroke prevention strategies.
AMERICAN HEART JOURNAL
(2022)
Article
Clinical Neurology
Sudipto Dolui, John A. Detre, Sarah A. Gaussoin, Jennifer S. Herrick, Danny J. J. Wang, Manjula Kurella Tamura, Monique E. Cho, William E. Haley, Lenore J. Launer, Henry A. Punzi, Anjay Rastogi, Carolyn H. Still, Daniel E. Weiner, Jackson T. Wright, Jeff D. Williamson, Clinton B. Wright, R. Nick Bryan, Adam P. Bress, Nicholas M. Pajewski, Ilya M. Nasrallah
Summary: Intensive antihypertensive treatment is associated with increased cerebral perfusion, particularly in patients with a history of cardiovascular disease.
Review
Medicine, General & Internal
Chase Paulson, Samuel C. Thomas, Orlando Gonzalez, Samuel Taylor, Cole Swiston, Jennifer S. Herrick, Lori McCoy, Karen Curtin, Craig J. Chaya, Brian C. Stagg, Barbara M. Wirostko
Summary: This study is the largest epidemiological study of exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in the Baja Verapaz region of Guatemala among individuals seeking eye exams and interventions. The study found a high prevalence of XFS/XFG, particularly among individuals in rural areas and those who speak the Mayan language.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xiaoyu Wang, Puya Gharahkhani, David M. Levine, Rebecca C. Fitzgerald, Ines Gockel, Douglas A. Corley, Harvey A. Risch, Leslie Bernstein, Wong-Ho Chow, Lynn Onstad, Nicholas J. Shaheen, Jesper Lagergren, Laura J. Hardie, Anna H. Wu, Paul D. P. Pharoah, Geoffrey Liu, Lesley A. Anderson, Prasad G. Iyer, Marilie D. Gammon, Carlos Caldas, Weimin Ye, Hugh Barr, Paul Moayyedi, Rebecca Harrison, R. G. Peter Watson, Stephen Attwood, Laura Chegwidden, Sharon B. Love, David MacDonald, John DeCaestecker, Hans Prenen, Katja Ott, Susanne Moebus, Marino Venerito, Hauke Lang, Rupert Mayershofer, Michael Knapp, Lothar Veits, Christian Gerges, Josef Weismueller, Matthias Reeh, Markus M. Noethen, Jakob R. Izbicki, Hendrik Manner, Horst Neuhaus, Thomas Roesch, Anne C. Boehmer, Arnulf H. Hoelscher, Mario Anders, Oliver Pech, Brigitte Schumacher, Claudia Schmidt, Thomas Schmidt, Tania Noder, Dietmar Lorenz, Michael Vieth, Andrea May, Timo Hess, Nicole Kreuser, Jessica Becker, Christian Ell, Ian Tomlinson, Claire Palles, Janusz A. Jankowski, David C. Whiteman, Stuart MacGregor, Johannes Schumacher, Thomas L. Vaughan, Matthew F. Buas, James Y. Dai
Summary: This study identified novel genetic susceptibility loci for esophageal adenocarcinoma and Barrett esophagus using an eQTL set-based genetic association approach, expanding the pool of genetic susceptibility loci.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medicine, General & Internal
Jordana B. Cohen, Zachary A. Marcum, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Daniel Scharfstein, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: This observational cohort study aimed to evaluate the cognitive outcomes of individuals at risk for mild cognitive impairment and probable dementia after initiating an ARB- vs ACEI-based antihypertensive regimen. The study found no significant difference in the rate of amnestic MCI or PD among new users of ARB compared with ACEI.
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jennifer S. Herrick, Robert S. Rosenson, Bharat Poudel, Monika M. Safford, Todd M. Brown, Elizabeth A. Jackson, Mark Woodward, Stephanie Reading, Kate Orroth, Jason Exter, Salim S. Virani, Paul Muntner, Adam P. Bress
Summary: This study investigated lipid-lowering therapy (LLT) among US veterans after myocardial infarction or elective coronary revascularization. The results showed that less than half of the patients received LLT intensification within one year, indicating a missed opportunity to reduce cardiovascular disease risk.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Peripheral Vascular Disease
Jordan B. King, Catherine G. Derington, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Molly B. Conroy, William C. Cushman, Adam P. Bress
Summary: This study aimed to assess the availability of commercially available single-pill combination (SPC) antihypertensive products for achieving an intensive systolic blood pressure goal of <120 mm Hg. The results showed that most participants in the intensive treatment arm were using antihypertensive regimens that are not available as class-equivalent SPC products. Therefore, improvements in the product landscape are needed to achieve the desired results in real-world settings and reduce medication burden.
Article
Peripheral Vascular Disease
Byron C. Jaeger, Ligong Chen, Kathryn Foti, Shakia T. Hardy, Adam P. Bress, Sean P. Kane, Lei Huang, Jennifer S. Herrick, Catherine G. Derington, Bharat Poudel, Ashley Christenson, Lisandro D. Colantonio, Paul Muntner
Summary: A web-based application was developed to provide hypertension statistics for US adults using data from the US National Health and Nutrition Examination Survey. The study found that the mean systolic blood pressure decreased from 123 mm Hg in 1999-2000 to 120 mm Hg in 2009-2010 and then increased to 123 mm Hg in 2017-2020. The age-adjusted prevalence of hypertension was 47.9% in 1999-2000, 43.0% in 2009-2010, and 44.7% in 2017-2020. The study also estimated that 115.3 million US adults had hypertension in 2017-2020.
Article
Cardiac & Cardiovascular Systems
Catherine G. G. Derington, Adam P. P. Bress, Jennifer S. S. Herrick, Joshua A. A. Jacobs, Alexander R. R. Zheutlin, Ransmond O. O. Berchie, Molly B. B. Conroy, William C. C. Cushman, Jordan B. B. King
Summary: It is found that only one-third of hypertensive patients in the US market can be satisfied with the currently available fixed-dose combination antihypertensive products, indicating the need for further improvement in the pharmaceutical product landscape.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Alexander R. Zheutlin, Daniel K. Addo, Joshua A. Jacobs, Catherine G. Derington, Jennifer S. Herrick, Tom Greene, Eric L. Stulberg, Dan R. Berlowitz, Jeff D. Williamson, Nicholas M. Pajewski, Mark A. Supiano, Adam P. Bress
Summary: Despite evidence supporting the benefits of intensive blood pressure management, older adults have the lowest rates of blood pressure control. The association between age and therapeutic inertia was determined in the SPRINT study, with older age found to be associated with greater therapeutic inertia independent of physical or cognitive function. This suggests age bias in hypertension management.
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)