Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 64, Issue 5, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00012-20
Keywords
Klebsiella; antibiotic resistance; carbapenemase; plazomicin
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Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) [UM1AI104681]
- NIH [R01AI100560, R01AI063517, R01AI072219, R01AI090155]
- National Institute of Allergy and Infectious Diseases [U19AI110819]
- Cleveland Department of Veterans Affairs from the Biomedical Laboratory Research and Development Service of the VA Office of Research and Development [1I01BX001974]
- Geriatric Research Education and Clinical Center [VISN 10]
- Achaogen
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Plazomicin was tested against 697 recently acquired carbapenemresistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of <= 2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of > 32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.
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