Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Medicine, General & Internal
Andrea Cuervo, Raquel Celis, Antonio Julia, Alicia Usategui, Regina Fare, Julio Ramirez, Ana Belen Azuaga, Andres Lorenzo, Raimon Sanmarti, Jose L. Pablos, Juan D. Canete
Summary: The study found that the cellular composition of synovium in undifferentiated arthritis (UA) patients differs from rheumatoid arthritis (RA) and psoriatic arthritis (PsA), with higher cellular infiltrate density in the UA group. Initial expression of the interferon inducible gene MxA may serve as a biomarker for progression to RA, while higher mast cell and fibroblastic density may be associated with PsA progression.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Katerina Chatzidionysiou, Alexandra Circiumaru, Bence Rethi, Vijay Joshua, Marianne Engstrom, Aase Hensvold, Erik af Klint, Anca Catrina
Summary: Tocilizumab reduced synovial T-cell counts but not macrophages in rheumatoid arthritis patients. A significant increase in serum IL-6 was observed in responders to tocilizumab.
Article
Rheumatology
Sascha L. Heckert, Sytske Anne Bergstra, Xanthe M. E. Matthijssen, Yvonne P. M. Goekoop-Ruiterman, Faouzia Fodili, Saskia Ten Wolde, Cornelia F. Allaart, Tom W. J. Huizinga
Summary: In patients with rheumatoid arthritis, baseline joint swelling was significantly associated with swelling in the same joint during follow-up, and it was found to better predict local joint swelling compared to baseline swelling in other joints. This suggests that local factors play a role in the recurrence of joint swelling over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Yi Qin, Ming-Long Cai, Hui-Zhi Jin, Wei Huang, Chen Zhu, Aline Bozec, Jingang Huang, Zhu Chen
Summary: This study found that ABCs contribute to the pathogenesis of RA by inducing the activation of FLS via TNF-alpha-mediated signaling pathways.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Silvia Hayer, Margriet J. Vervoordeldonk, Maria C. Denis, Marietta Armaka, Markus Hoffmann, Johan Backlund, Kutty Selva Nandakumar, Birgit Niederreiter, Christina Geka, Anita Fischer, Nina Woodworth, Stephan Blueml, George Kollias, Rikard Holmdahl, Florence Apparailly, Marije Koenders
Summary: Animal models for inflammatory arthritides like rheumatoid arthritis and psoriatic arthritis are widely used for research, but many publications lack detailed descriptions and evaluations of arthritis pathology. The European consortium BeTheCure developed SMASH recommendations for standardised histological evaluation to improve information and promote reproducibility in preclinical research on inflammatory arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Clement Triaille, Gaelle Tilman, Tatiana Sokolova, Axelle Loriot, Joelle Marchandise, Stephanie De Montjoye, Adrien Nzeusseu-Toukap, Laurent Meric de Bellefon, Caroline Bouzin, Christine Galant, Patrick Durez, Bernard R. Lauwerys, Nisha Limaye
Summary: This study used transcriptomic profiling to explore clinically relevant subgroups in early, untreated rheumatoid arthritis (RA) patients. The synovial transcriptome closely mirrored clinical disease activity, and the ratio of M2:M1 macrophages was inversely correlated with inflammation and disease activity, suggesting a protective role for tissue resident macrophages in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Alen Zabotti, Gabriele De Marco, Laure Gossec, Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco, Paolo Gisondi, Peter Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S. Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Ruben Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A. Stamm, Paul Studenic, Ilaria Tinazzi, Filip E. Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S. Smolen, Dennis G. McGonagle
Summary: This study proposes EULAR guidelines for the early diagnosis of psoriatic arthritis (PsA) by conducting research on multiple patients. It also establishes standardized operating procedures for clinical practice and trials, providing guidance and consensus in the field of prevention and interception of PsA for psoriasis patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Smadar Gertel, Ari Polachek, Victoria Furer, David Levartovsky, Ori Elkayam
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with T cell dysregulation. LAG-3 expression on CD4(+) T cells was found to be lower in patients with active disease compared to those with minimal disease activity, and anti-TNF treatment was able to restore the levels of LAG-3(+) T cells in non-MDA patients. Lower soluble LAG-3 levels were also observed in the sera of PsA patients compared to healthy controls.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Rheumatology
Nadia M. T. Roodenrijs, Melinda Kedves, Attila Hamar, Gyorgy Nagy, Jacob M. van Laar, Desiree van der Heijde, Paco M. J. Welsing
Summary: This study summarized the evidence on diagnostic issues in difficult-to-treat rheumatoid arthritis (D2T RA) and found a scarcity of high-quality studies, no diagnostic tests with sufficient validity and accuracy identified, with ultrasonography (US) showing promise for assessing inflammatory activity.
Review
Rheumatology
Aurelie Najm, Felicie Costantino, Catherine Weill, Andrew Filer, Maria Antonieta D'Agostino
Summary: This study aims to summarize the impact of biopsy procedures, tissue handling, tissue quality, and disease-specific factors on synovial tissue outcome. The study found that study design, population, sample handling, randomization, and analysis can affect the final results of synovial tissue research.
Article
Rheumatology
Raphael Micheroli, Muriel Elhai, Sam Edalat, Mojca Frank-Bertoncelj, Kristina Buerki, Adrian Ciurea, Lucy MacDonald, Mariola Kurowska-Stolarska, Myles J. Lewis, Katriona Goldmann, Cankut Cubuk, Tadeja Kuret, Oliver Distler, Costantino Pitzalis, Caroline Ospelt
Summary: This study integrated single-cell RNA sequencing data to assess the contribution of synovial fibroblast subsets to synovial pathotypes and clinical characteristics in treatment-naive early arthritis. The findings revealed a previously unexplored association between specific synovial pathologies and subtypes of synovial fibroblasts.
Article
Immunology
Claudia Macaubas, Shamma S. Rahman, Idit Lavi, Amir Haddad, Muna Elias, Deepanwita Sengupta, Devy Zisman, Elizabeth D. Mellins
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that affects a significant portion of patients with psoriasis. In this study, high dimensional mass cytometry was used to analyze the levels of phosphorylated STAT3 (pSTAT3) in different immune cell subpopulations from PsA patients. The results showed that during active PsA, multiple immune cell subpopulations had increased levels of pSTAT3, potentially playing a role in the pathophysiology of PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Alessandra Nerviani, Marie-Astrid Boutet, Wang Sin Gina Tan, Katriona Goldmann, Nirupam Purkayastha, Tamas Ajtos Lajtos, Rebecca Hands, Myles Lewis, Stephen Kelly, Costantino Pitzalis
Summary: This study revealed distinct differences in gene expression between synovial and skin tissues in PsA patients, particularly in the heterogeneous expression of the IL-23 axis. IL-23 transcriptomic/protein expression was strongly linked to patients with high-grade synovitis, aiding in identifying those who may respond better to IL-23 inhibitors.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
