Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 21, Pages 8148-8152Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202002399
Keywords
elastin; fibrous proteins; protein fibers; protein engineering; wet spinning
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Funding
- Scientific Instrument Developing Project of the Chinese Academy of Sciences [ZDKYYQ20180001]
- Jilin Province Science Fund for Excellent Young Scholars [20190103072JH]
- K. C. Wong Education Foundation [GJTD-2018-09]
- National Natural Science Foundation of China [21704099, 21877104, 21834007]
- National Key R&D Program of China [2018YFA0902600]
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Silk-protein-based fibers have attracted considerable interest due to their low weight and extraordinary mechanical properties. Most studies on fibrous proteins focus on the recombinant spidroins, but these fibers exhibit moderate mechanical performance. Thus, the development of alternative structural proteins for the construction of robust fibers is an attractive goal. Herein, we report a class of biological fibers produced using a designed chimeric protein, which consists of the sequences of a cationic elastin-like polypeptide and a squid ring teeth protein. Remarkably, the chimeric protein fibers exhibit a breaking strength up to about 630 MPa and a corresponding toughness as high as about 130 MJm(-3), making them superior to many recombinant spider silks and even comparable to some native counterparts. Therefore, this strategy is a novel concept for exploring bioinspired ultrastrong protein materials through the development of new types of structural chimeric proteins.
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