Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 8, Pages 3131-3136Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915046
Keywords
aggregation-induced emission; human serum albumin; paper-based analytical devices; point-of-care; ratiometric detection
Categories
Funding
- National Natural Science Foundation of China [21602139, 21575045]
- Australia Research Council [FT160100039]
- Australian Research Council [FL150100060]
- UNSW
- Australian Research Council [FL150100060, FT160100039] Funding Source: Australian Research Council
Ask authors/readers for more resources
Monitoring of human serum albumin (HSA) in a point-of-care fashion is urgently needed in particular for elderly or chronically ill patients. Herein, a dual-state emissive chalcone probe having the feature of aggregation-induced emission was designed and synthesized. The concentration of HSA can be evaluated by the ratios of emission from probes in aggregated and monomeric state, which gives a visually discernible red-to-green color change. A simple, portable paper-based analytical device have been fabricated by integration of the recognition probe in the detection pad and employed for HSA test using the whole blood samples. This paper-based assay shows the analytical capability comparable to the standard testing methods but is in a point-of-care fashion, providing a promising tool for at-home HSA detection and HSA-related disease diagnosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available