Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 12, Pages 4851-4855Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201914500
Keywords
B-H activation; carborane; catalysis; migration; palladium
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Funding
- National Natural Science Foundation of China [21772223]
- Science and Technology Commission of Shanghai Municipality [18590760800]
- Chinese Academy of Sciences
- Hong Kong RGC [14305018, 14305918]
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A palladium-catalyzed highly selective 3,4-bifunctionalization of 3-I-o-carborane has been developed, leading to the preparation of 3-alkenyl-4-R-o-carboranes (R=alkyl, alkynyl, aryl, allyl, CN, and amido) in high to excellent yields. This protocol combines the sequential activation of cage B(3)-I and B(4)-H bonds by Pd migration from exo-alkenyl sp(2) C to cage B(4), which is driven by thermodynamic force. This represents a brand-new strategy for selective bifunctionalization of carboranes with two different substituents.
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