Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 4, Pages 1496-1500Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201912169
Keywords
design of experiments; dynamic covalent chemistry; macrocycles; self-assembly; supramolecular chemistry
Categories
Funding
- US National Science Foundation (NSF) [CHE-1609926]
- NSF Graduate Research Fellowship Program [1309047]
- NSF [CHE-1625529]
- Bradshaw and Holzapfel Research Professorship in Transformational Science and Mathematics
Ask authors/readers for more resources
Cyclophanes are a venerable class of macrocyclic and cage compounds that often contain unusual conformations, high strain, and unusual properties. However, synthesis of complex, functional derivatives remains difficult due to low functional group tolerance, high dilution, extreme reaction conditions, and sometimes low yields using traditional stepwise synthetic methods. Design of experiments (DOE) is a method employed for the optimization of reaction conditions, and we showcase this approach to generate a dramatic increase in the yield of specific targets from two different self-assembling systems. These examples demonstrate that DOE provides an additional tool in tuning self-assembling, dynamic covalent systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available