Article
Chemistry, Multidisciplinary
Yongli Li, Dalong Shen, Hao Zhang, Zhenxing Liu
Summary: Due to the increasing demand for sustainable organic chemistry, the development of green and powerful methods for C-C and C-B bond formation is highly desired. Transition-metal-free coupling reactions of gem-diborylalkanes have emerged as valuable tools for organic chemists in the past decade. This review presents selected representative examples and compares these reactions to transition-metal-catalyzed reactions. The recent formation of alpha-boryl radicals from gem-diborylalkanes is also briefly discussed.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Medicinal
Feiyan Zhan, Jingjie Zhu, Shaowen Xie, Jinyi Xu, Shengtao Xu
Summary: Bioorthogonal coupling reactions have gained significant interest for their substrate selectivity and less restrictive reaction conditions, making them powerful tools in drug development. This review discusses the current applications of bioorthogonal coupling reactions in compound library building, druggability optimization, and intracellular self-assembly platforms, presenting a new trend in drug development for accelerating lead compound screening and expanding the variety of designed compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Naish Lalloo, Conor E. Brigham, Melanie S. Sanford
Summary: Transition-metal-catalyzed decarbonylative coupling reactions using carboxylic acid derivatives as electrophiles have the advantages of abundant and inexpensive reactants. This Account highlights the development of base-free decarbonylative coupling reactions catalyzed by group 10 metals and discusses the catalyst design guided by stoichiometric organometallic studies. The article also discusses the challenges and future directions in this field.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Physical
Yu Yan, Xiaonan Zheng, Xiaoxiao Li, Yuan Yao, Yang Liu
Summary: This study investigates the use of adjacent single-metal sites as a way to improve the activity of single-atom catalysts through a modulation effect. By using first-principle calculations, a CoN4-ZnN4/C catalyst anchored on nitrogen-doped graphene is predicted to show promising electrocatalytic activity for oxygen reduction and evolution reactions, outperforming commercial benchmarks. The enhanced catalytic activity is attributed to the asymmetric deformation and pseudo-Jahn-Teller vibronic coupling effect induced by the Zn site.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Han Byeol Kim, Hee Jin Jeong, Jae Eun Jung, Jae Kyun Lee, Duck-Hyung Lee, Seo-Jung Han
Summary: A mild, efficient, and transition-metal-free three-component coupling reaction involving arynes, phosphites, and aldehydes was established. It produced 3-mono-substituted benzoxaphosphole 1-oxides. A range of 3-mono-substituted benzoxaphosphole 1-oxides was obtained from both aryl- and aliphatic-substituted aldehydes in moderate to good yields. The reaction's synthetic utility was demonstrated by a Gram-scale reaction and the transformation of the products into various P-containing bicycles.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Organic
Yaseen Hussain, Tamanna, Manisha Sharma, Akshay Kumar, Pankaj Chauhan
Summary: Organocatalysts have shown potential in facilitating remote functionalizations, with the 1,6-addition reaction as a key strategy for creating stereocenters. Furthermore, organocatalysis has enabled the development of complex synthesis through domino reactions.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Multidisciplinary
You Wang, Yuli He, Shaolin Zhu
Summary: Migratory cross-coupling via metal migration is a significant process in academic and industrial fields, providing an attractive alternative for the synthesis of challenging structures. This Account outlines recent progress and developments in the field, including migration-functionalization modes, diverse functionalizations, and strategies for regio- and stereocontrol.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Physical
Yanhong Liu, Aili Feng, Rongxiu Zhu, Chengbu Liu, Dongju Zhang
Summary: Density functional theory (DFT) calculations were performed to investigate the mechanism of copper-catalyzed four-component borocarbonylative coupling of alkenes with alkyl halides using bis(pinacolato)diboron as the boron reagent under CO atmosphere. The theoretical results revealed an unexpected reaction mechanism involving CuI as the sole catalyst, with a two-ligand relay mechanism and no radical participation, proceeding through SN2-type C-C coupling. The experimental observations of regio- and chemoselectivities, as well as the inhibition of the reaction by radical trapping reagents, were rationalized by the theoretical analysis.
JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Analytical
Haizhi Zhang, Huanyu Yang, Pei Liu, Xinguang Qin, Gang Liu
Summary: A rapid colorimetric method for detecting sodium benzoate in food products was established based on D-amino acid oxidase (DAAO) and 2D metal organic framework (2D MOF) nanosheets mediated cascade enzyme reactions. The method showed wide linear range, low limit of detection, high accuracy, and satisfied selectivity, and was successfully used for analyzing sodium benzoate concentration in juice, wine, and vinegar by naked eyes.
Article
Engineering, Electrical & Electronic
Tianhong Tan, Tao Jiang, Haolin Jiang, Tianhao Wang, Mingjuan Cai
Summary: In this paper, the uncertainty quantification of a crosstalk calculation model of braided-shielded cable is explored using polynomial chaos expansions (PCE) method. The model is expanded by PCE and the truncation degrees of polynomials and sample size are determined. The statistical characteristic parameters of crosstalk are obtained by combining the coefficients of polynomials. The results obtained by PCE method show obvious advantages in calculation efficiency compared with the Monte Carlo method.
APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Kaan Karaoglu, Zehra Ozcifci, Melike Caliskan, Hakki Turker Akcay, Talat Baran
Summary: In this study, a ZnO-Pd nanocatalyst was prepared on activated carbon sourced from polymer debris for use in Heck-type coupling reactions. The hybrid material was characterized using techniques such as TEM, XRD, and BET surface area analysis. The designed hybrid catalyst exhibited a reaction yield of more than 90% in cross-coupling reactions and demonstrated remarkable stability up to 5 cycles in recycling tests.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Food Science & Technology
Jung-Whan Chon, Kun-Ho Seo
Summary: A new medium for detection of Bacillus cereus, B. cereus chromogenic agar (BCCA), showed similar or better recoverability and inclusivity/exclusivity compared to conventional and commercial chromogenic media. BCCA also exhibited enhanced levels of recoverability and superior selectivity of B. cereus from ready-to-eat food products, particularly radish sprouts and a sprout mix, making it a useful option for isolation and enumeration of B. cereus from commercial foods.
Article
Chemistry, Multidisciplinary
Clementine Pescheteau, Matthieu Place, Alexandru Sava, Lea Nunes, Lenuta Profire, Sylvain Routier, Frederic Buron
Summary: The first access to 3,5-disubstituted imidazo[1,2-d][1,2,4]thiadiazole derivatives is reported. The method involves the synthesis of a key intermediate from 2-mercaptoimidazole and the regioselective electrophilic iodination in the C-5 position using the Suzuki-Miyaura reaction. Palladium-catalyzed cross-coupling reactions with various boronic acids were optimized to establish the scope and limitations of the method.
Article
Biochemistry & Molecular Biology
Asma Hrizi, Manon Cailler, Moufida Romdhani-Younes, Yvan Carcenac, Jerome Thibonnet
Summary: This study describes a method for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction. The reactivity of indole derivatives with iodine at position 3 was studied using various cross-coupling reactions. Sonogashira, Suzuki-Miyaura, Stille, and Heck cross-couplings provided a variety of di-, tri- and tetra-substituted indole-2-carbonitriles.
Article
Biochemistry & Molecular Biology
Takumi Yanase, Junko Okuda-Shimazaki, Ryutaro Asano, Kazunori Ikebukuro, Koji Sode, Wakako Tsugawa
Summary: The aim of this research is to develop a versatile method for creating a DET-type oxidoreductase complex based on the SpyCatcher/SpyTag technique. By combining SpyCatcher-fused heme c and SpyTag-fused non-DET-type oxidoreductases, DET-type oxidoreductase complexes with retained enzymatic activity and electron transfer ability to the electrode were successfully formed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Saranya Krishnan, Shina Sasi, Preshobha Kodakkattumannil, Salima Al Senaani, Geetha Lekshmi, Martin Kottackal, Khaled M. A. Amiri
Summary: This study aimed to develop an efficient DNA extraction protocol suitable for diverse plant species and tissues. A reliable and consistent protocol was described for the extraction of high-quality DNA from difficult-to-extract plant species. The optimized protocol was successful in extracting high-quality DNA from various plant species and tissues, making it useful for genomic studies of recalcitrant plants.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Eisaku Hokazono, Saori Fukumoto, Takeshi Uchiumi, Susumu Osawa
Summary: This study proposes a method for detecting nucleic acid amplification using pyrophosphate, which requires only two reagents and an automated analyzer. The technique has high sensitivity and reproducibility, and can detect pyrophosphate within 10 minutes. Therefore, this method has the potential to be a new, rapid, and simple detection technique for amplified nucleic acids.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Drew S. Sowersby, L. Kevin Lewis
Summary: SURE electrophoresis is a new method for concentrating samples in gels, which allows efficient detection of highly dilute DNA samples. This approach generates single bands with enhanced signal intensities and minimal band broadening.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Hongyi Liang, Guoliang Yin, Guangxi Shi, Zhiyong Liu, Xiaofei Liu, Jingwei Li
Summary: The mechanism of Echinacoside (ECH) in treating breast cancer (BC) was explored through network pharmacology and experimental validation. It was found that ECH plays an important role in anti-BC by regulating the PI3K/AKT/HIF-1 alpha/VEGF signaling pathway, and it exhibits multi-target and multi-pathway effects.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Daniel S. Kantner, Emily Megill, Anna Bostwick, Vicky Yang, Carmen Bekeova, Alexandria Van Scoyk, Erin L. Seifert, Michael W. Deininger, Nathaniel W. Snyder
Summary: This study compared the results of different methods for measuring the amount of acetyl-Coenzyme A. The colorimetric ELISA kit did not produce interpretable results, while the fluorometric enzymatic kit showed comparable results to the LC-MS-based methods depending on the matrix and extraction conditions. LC-MS/MS and LC-HRMS methods produced well-aligned results, especially when using stable isotope-labeled internal standards.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Jingyan Xu, Hanying Tan, Xionghui Ma, Linjing Su, Zhi Zhang, Yuhao Xiong
Summary: This study investigates the co-catalytic capabilities of MoO3 nanosheets in enhancing the enzyme-like catalytic activity of a two-dimensional ultrathin Fe(III)-modified covalent triazine framework (Fe-CTF) under neutral pH conditions. The Fe-CTF/MoO3 co-catalytic system exhibits enzyme-mimicking activity and enables the development of a colorimetric method for glucose detection. Furthermore, a straightforward one-pot colorimetric method is established for screening XOD inhibitors.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Lichao Zhang, Kang Xiao, Xueting Wang, Liang Kong
Summary: A novel fusion technology was designed to identify FAD-binding sites, achieving the best results on two independent test datasets and outperforming existing methods significantly. The high performance and certainty of the method were demonstrated through statistical tests and cross-entropy loss analysis.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Abdulkadir Kilic, Mehmet Aslan, Abdulkadir Levent
Summary: This study developed a simple, rapid, sensitive, and selective voltammetric technique for the electrochemical characterization and detection of the highly risky drug Edoxaban. The optimized voltammetric method showed good analytical working range and was successfully applied to urine and tablet samples.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Su Hyun Kim, Nara Shin, Jong-Min Jeon, Jeong-Jun Yoon, Jeong Chan Joo, Hee Taek Kim, Shashi Kant Bhatia, Yung-Hun Yang
Summary: To address environmental issues caused by traditional plastics, bioplastics have gained attention as alternatives. Although bioplastics have better degradability, their degradation still takes longer than anticipated. This study proposes a novel screening method to identify bioplastic degraders faster, saving time and providing more quantitative data.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Irem Okman Kocoglu, Pinar Esra Erden, Esma Kilic
Summary: In this study, an electrochemical biosensor based on carbon nanofibers and ionic liquid modification was constructed for tyramine detection. The biosensor showed linear response, low detection limit, high sensitivity, and exhibited good reproducibility, stability, and anti-interference ability.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Liana U. Akhmetzianova, Timur M. Davletkulov, Assol R. Sakhabutdinova, Alexey Chemeris, Irek M. Gubaydullin, Ravil R. Garafutdinov
Summary: A new program called LAMPrimers iQ has been developed for high-quality LAMP primer design, and its advantages in providing higher specificity and reliable detection of viral RNA were validated using SARS-CoV-2 coronavirus RNA as a model target.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Tommaso Pileri, Alberto Sinibaldi, Agostino Occhicone, Norbert Danz, Elena Giordani, Matteo Allegretti, Frank Sonntag, Peter Munzert, Patrizio Giacomini, Francesco Michelotti
Summary: This study developed a biosensing device based on one-dimensional photonic crystal to detect HER2 in breast cancer. The device combines label-free and fluorescence operation modes, allowing for real-time and accurate detection in less than 20 minutes. It offers a promising technique for combined label-free and fluorescence detection in disease diagnosis and therapeutic monitoring.
ANALYTICAL BIOCHEMISTRY
(2024)