Article
Immunology
Milan J. Sonneveld, Bettina E. Hansen, Willem P. Brouwer, Henry L-Y Chan, Teerha Piratvisuth, Ji-Dong Jia, Stefan Zeuzem, Rong-Nan Chien, Robert J. de Knegt, Cynthia Wat, Vedran Pavlovic, Anuj Gaggar, Qing Xie, Maria Buti, Robert A. de Man, Harry L. A. Janssen
Summary: This study investigated the relationship between HBsAg levels and hepatic fibrosis and cirrhosis in patients with chronic hepatitis B. The results showed that lower HBsAg levels were associated with higher rates of fibrosis and cirrhosis in HBeAg-positive patients, but not in HBeAg-negative patients. Additionally, genotype-specific HBsAg cutoffs could be used to rule out the presence of cirrhosis. These findings are important for the diagnosis and treatment of chronic hepatitis B patients.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Tai-Chung Tseng, Chieh Chiang, Chun-Jen Liu, Chun-Ming Hong, Tung-Hung Su, Hung-Chih Yang, Wan-Ting Yang, Chen-Hua Liu, Pei-Jer Chen, Jia-Horng Kao
Summary: This study aimed to explore the association between spontaneous seroclearance of hepatitis B surface antigen (HBsAg) and hepatitis B core-related antigen (HBcrAg) levels. The results showed that lower HBcrAg levels were associated with an increased likelihood of HBsAg seroclearance. Especially for patients with HBsAg levels >1000 IU/mL, HBcrAg levels <10,000 U/mL served as an independent predictor for HBsAg seroclearance.
Article
Immunology
Noe Rico Montanari, Ricardo Ramirez, Nick Van Buuren, Thierry P. P. van den Bosch, Michail Doukas, Jose D. Debes, Becket Feierbach, Andre Boonstra
Summary: This study found a dysregulated liver transcriptome in inactive carriers of chronic hepatitis B virus (HBV) compared to healthy liver donors, despite normal liver function. Diverse levels of HBsAg have minimal impact on the liver transcriptome in inactive carriers, but gene correlation analysis revealed correlations with leukocyte activation, recruitment, and innate responses genes.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Takanori Suzuki, Kentaro Matsuura, Takehisa Watanabe, Takeshi Matsui, Shintaro Ogawa, Hayato Kawamura, Kayoko Kuno, Kei Fujiwara, Shunsuke Nojiri, Hiromi Kataoka, Yasuhito Tanaka
Summary: Two novel assays, iTACT-HBcrAg and iTACT-HBsAg, have been developed to investigate the longitudinal profiles of these antigens in HBsAg seroclearance patients. The presence of HBcrAg may contribute to the progression of chronic hepatitis B.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Analytical
Vivek K. Bajpai, Yuvraj Haldorai, Imran Khan, Sonam Sonwal, Mahendra Pal Singh, Seema Yadav, Bilal Ahamad Paray, Basit Latief Jan, Sung-Min Kang, Yun Suk Huh, Young-Kyu Han, Shruti Shukla
Summary: An ultrasensitive electrochemical immunosensor was developed using an immunofunctionalized zirconium-based metal-organic framework with gold decoration, for the determination of infectious hepatitis B surface antigen. The sensor showed good selectivity and reproducibility, with excellent performance in terms of detection limit.
Review
Gastroenterology & Hepatology
Peter Schemmer, Patrizia Burra, Rey-Heng Hu, Christian M. Hueber, Carmelo Loinaz, Keigo Machida, Arndt Vogel, Didier Samuel
Summary: Chronic HBV infection is a major cause of HCC, with HBsAg playing a direct oncogenic role through various mechanisms. HBV-related HCC recurrence post-surgery may involve expansion of residual tumor cells and independent replication of HBV. The role of HBsAg in HCC development and recurrence post-surgical intervention has implications for immunotherapy.
LIVER INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Satinder P. Kaur, Arslan Talat, Hamidreza Karimi-Sari, Andrew Grees, Hao Wei Chen, Daryl T. Y. Lau, Andreea M. Catana
Summary: Hepatitis B virus (HBV) infection is one of the main risk factors for hepatocellular carcinoma (HCC), and the risk of HCC is not completely eliminated even after viral suppression. Cirrhosis, HBV viral DNA levels, age, male gender, the immune response, and a combination of obesity and diabetes are among the main risk factors for HCC. Active viral replication and long-standing inflammation are associated with a higher risk of HCC. Treatment of HBV with nucleos(t)ide analogues can decrease the risk of HCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Yan-Wei Zhong, Yan-Min Shi, Fang Chu, Jie Liu, Ce Shi, Jiao-Jiao Xu, Peng Liu, Yan-Jie Bai, Xiao-He Xiao, Xiu-Chang Zhang, Min Zhang
Summary: This study showed that baseline serum HBsAg or intrahepatic cccDNA can predict HBsAg seroconversion in children with chronic hepatitis B, which can help clinicians choose more rational therapeutic strategies.
BMC INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Fengping Wu, Rui Lu, Yixin Liu, Yikai Wang, Yan Tian, Yaping Li, Mei Li, Wenjun Wang, Xin Zhang, Xiaoli Jia, Shuangsuo Dang
Summary: This study demonstrates that peg-IFN-alpha monotherapy is highly effective and safe for inactive hepatitis B virus carriers, leading to significantly higher rates of HBsAg clearance and seroconversion in the treatment group compared to the control group.
LIVER INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
Shelina Moonsamy, Melinda Suchard, Pavitra Pillay, Nishi Prabdial-Sing
Summary: The study found that the prevalence of hepatitis B infection in South Africa has been increasing annually, with higher rates in males than females, highest among individuals aged 25 to 49, and highest in the Gauteng province. The HBsAg test positivity rate has been decreasing annually, with higher rates in males, individuals aged 25-49, and those in the Limpopo province.
Article
Immunology
Yali Wu, Xiaoxiao Wang, Xiao Lin, Chengli Shen, Xinyue Chen
Summary: The study suggests that quantitative Anti-HBc levels can serve as a potential predictor for recurrence in patients with CHB after achieving HBsAg clearance. Anti-HBc levels at drug withdrawal show better predictive value than at baseline, with sensitivity and specificity at >2.3386 log10 IU/mL being 80.0% and 71.9% respectively.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Virology
Aixin Song, Xiao Lin, Xinyue Chen
Summary: HBsAg clearance is considered the ideal endpoint for antiviral treatment, with recent advances in combined and extended treatment strategies improving clearance rates. However, durability and clinical outcomes post-clearance remain areas of focus for researchers and clinicians.
Article
Gastroenterology & Hepatology
Mojahidul Islam, Jayesh Kumar Sevak, Manoj Kumar Sharma, Ankur Jindal, Ashish Kumar Vyas, Meenu Bajpai, Gayatri Ramakrishna, Shiv Kumar Sarin, Nirupma Trehanpati
Summary: Hepatitis B reactivation (rHBV) patients show immune differentiation and tolerance abrogation after HBsAg seroconversion. Non-seroconverters exhibit increased inhibitory markers on CD4/CD8 T cells. CD8, Tfh, and B cells and subsets play a critical role in seroclearance during HBV infection.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
S. Reza Mahmoodi, Pengfei Xie, Daniel P. Zachs, Erik J. Peterson, Rachel S. Graham, Claire R. W. Kaiser, Hubert H. Lim, Mark G. Allen, Mehdi Javanmard
Summary: A non-faradaic label-free cortisol sensing platform was developed using a nanowell array design, allowing for rapid and low volume sensing. The sensor, built on a glass substrate, showed a good response to cortisol concentrations and compared well with results from standard ELISA. Nanowell array sensors have potential to be a promising platform for point-of-care testing.
Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Chutimon Akkapinyo, Kittitat Subannajui, Yingyot Poo-arporn, Rungtiva P. Poo-arporn
Summary: A facile synthesis method for rGO-methionine/SPCE disposable sensor was proposed for determination of food colorants, showing enhanced catalytic activity and high performance for real sample analysis. This modified sensor demonstrated good repeatability and high tolerance to interference substances, with optimized detection ranges and limit of detection for each dye.
Article
Chemistry, Physical
Nichapha Senamart, Sirinuch Loiha, Yingyot Poo-arporn, Pimrapas Tawachkultanadilok, Surangrat Tonlublao, Wanwisa Limphirat, Suriya Duangmanee, Phitsamai Kamonpha, Jatuporn Wittayakun, Nattawut Osakoo, Suttipong Wannapaiboon, Rungtiva P. Poo-arporn
Summary: The study investigated the performance of Fe3O4 catalysts with Ni and Cr dopants in ethanol steam reforming reaction, with NiFe2O4 demonstrating the highest catalytic activity and stability for hydrogen production. The incorporation of Ni in the spinel ferrite structure enhanced reduction efficiency of iron compounds, improving catalytic activity and stability during the ESR process. Additionally, NiFe2O4 catalyst showed the ability to regenerate during the ESR process, as confirmed by X-ray absorption spectroscopy.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Chemistry, Physical
Khanittha Kerdpol, Bodee Nutho, Kuakarun Krusong, Rungtiva P. Poo-arporn, Thanyada Rungrotmongkol, Supot Hannongbua
Summary: By using molecular dynamics simulations, this study investigated the encapsulation of alpha-tocopherol with CD26, a supramolecular complex, and found that alpha-tocopherol spontaneously interacts with CD26 within 20 ns and forms a stable inclusion complex during 150-400 ns. The results showed that there were two groups of inclusion complexes, fully and partly encapsulated, which can enhance the solubility and stability of alpha-tocopherol.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Buchitar Nakwanich, Amonchat Koonwong, Anwaraporn Suramitr, Panida Prompinit, Rungtiva P. Poo-arporn, Supa Hannongbua, Songwut Suramitr
Summary: Three colorimetric anion sensors based on salicylidene Schiff bases were comprehensively studied for the detection of fluoride ions, with experimental methods and theoretical calculations revealing differences in performance and detection mechanisms.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Thammanoon Thaweechai, Weekit Sirisaksoontorn, Yingyot Poo-Arporn, Narong Chanlek, Supapan Seraphin, Surachai Thachepan, Rungtiva P. Poo-Arporn, Songwut Suramitr
Summary: The transparent nanocomposite sol of graphene quantum dot and amorphous TiO2 (GQD/a-TiO2) showed enhanced photocatalytic activity in degradation of RhB due to the interactions between surface functional groups on GQD sheets and a-TiO2, leading to band gap narrowing and synergistic effects. The smaller size of GQD facilitated greater extent of interactions at nanoscopic level, resulting in improved photocatalytic performance.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Anwaraporn Suramitr, Songwut Suramitr, Chayada Homhual, Natthakarn Saensanar, Yingyot Poo-arporn, Narong Chanlek, Rungtiva P. P. Poo-arporn
Summary: This study reports the synthesis of cobalt sulfide and reduced graphene oxide-cobalt sulfide composites via a facile hydrothermal method for wastewater remediation. The addition of reduced graphene oxide enhances the photocatalytic activity of cobalt sulfide by shortening the charge transportation time and suppressing electron-hole pair recombination.
Article
Chemistry, Analytical
Saithip Pakapongpan, Yingyot Poo-arporn, Adisorn Tuantranont, Rungtiva P. Poo-arporn
Summary: In this study, a simple one-pot solvothermal synthesis approach was used to fabricate a magnetic iron oxide embed nitrogen-doped graphene nanohybrid. This nanohybrid was then applied in an electrochemical sensor for the ultrasensitive detection of antibiotic residue contamination in milk samples. The sensor demonstrated excellent performance with high sensitivity, selectivity, and fast detection.
Article
Polymer Science
Mattanun Sangkhawasi, Tawun Remsungnen, Alisa S. Vangnai, Rungtiva P. Poo-arporn, Thanyada Rungrotmongkol
Summary: This study compared the structural dynamics and physical properties of bio-based material polyethylene vanillic (PEV) and commonly used polymer polyethylene terephthalate (PET) using computational methods. The results showed that PEV had higher flexibility and glass transition temperature than PET, consistent with experimental evidence.
Article
Chemistry, Multidisciplinary
Suriya Duangmanee, Yingyot Poo-arporn, Pattanaphong Janphuang, Pimchanok Leuasoongnoen, Surangrat Tonlublao, Phitsamai Kamonpha, Natawan Saengchai, Narong Chanlek, Chatree Saisombat, Pinit Kidkhunthod, Rungtiva P. Poo-arporn
Summary: In this study, a simple and facile growth method was used to fabricate vertically aligned ZnO thin films, which were then applied in methane gas sensors. The results showed a good correlation between the film structure and sensor response.
Article
Biology
Duangjai Todsaporn, Panupong Mahalapbutr, Rungtiva P. Poo-arporn, Kiattawee Choowongkomon, Thanyada Rungrotmongkol
Summary: In this study, the effects of EGFR mutations on the susceptibility of different EGFR inhibitors were investigated using comprehensive molecular modeling and in vitro kinase inhibition assays. The results showed that three hot-spot residues were involved in the binding of osimertinib and afatinib to mutated EGFRs, enhancing their inhibitory activity. Furthermore, principal component analysis revealed that the molecular complexation of osimertinib against mutated EGFRs was in a closed conformation, leading to drug resistance.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Termsak Tantiwiwat, Apisitt Thaiprayoon, Ake-Kavitch Siriatcharanon, Chakrit Tachaapaikoon, Nongluk Plongthongkum, Dujduan Waraho-Zhmayev
Summary: This study explores the potential usefulness of E. coli as an alternative expression system for producing the receptor-binding domain (RBD) of SARS-CoV-2, which can be used for the development of a cost-effective and flexible neutralizing antibody detection assay. The results suggest that non-glycosylated RBD produced from E. coli may be a viable alternative to expensive glycosylated RBD produced from human cells in the development of such an assay.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Phoomintara Longsompurana, Thanyada Rungrotmongkol, Nongluk Plongthongkum, Kittikhun Wangkanont, Peter Wolschann, Rungtiva P. Poo-arporn
Summary: The COVID-19 pandemic has created a need for effective therapeutic and diagnostic strategies. In this study, computational techniques were used to develop neutralizing nanobodies (Nbs) that can effectively neutralize SARS-CoV-2 variants. The engineered Nbs show potential for the development of novel treatment, prevention, and diagnostic strategies against SARS-CoV-2.
Article
Chemistry, Multidisciplinary
Kanyani Sangpheak, Dujduan Waraho-zhmayev, Korakod Haonoo, Sarun Torpaiboon, Tarin Teacharsripaiboon, Thanyada Rungrotmongkol, Rungtiva P. Poo-arporn
Summary: The study successfully designed a humanized antibody with enhanced binding affinity and solubility through a single S106D mutation using computational methods. These SDR antibodies showed significantly greater binding affinity and solubility compared to CDR and chimeric mAbs, suggesting greater efficacy for future use in humans.
Proceedings Paper
Agriculture, Multidisciplinary
A. Kamthong, R. P. Poo-arporn, D. Waraho-Zhmayev
6TH INTERNATIONAL CONFERENCE ON AGRICULTURAL AND BIOLOGICAL SCIENCES
(2020)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)