Review
Chemistry, Multidisciplinary
Chao Zhang, Tarun Belwal, Zisheng Luo, Bin Su, Xingyu Lin
Summary: This article comprehensively discusses the application of different nanomaterials in isothermal nucleic acid amplification, including the roles of 0D, 1D, 2D, and 3D nanomaterials, as well as recent progress in the field. Nanomaterials are commonly used for reaction enhancement, signal generation/amplification, or surface loading. Additionally, 3D nanomaterials can serve as isolated chambers for digital nucleic acid amplification and DNA sequencing tools, while challenges and recommendations are proposed for future applications.
Article
Chemistry, Multidisciplinary
Linzhe Chen, Jingyi Ding, Hao Yuan, Chi Chen, Zida Li
Summary: The authors developed a deep learning-enabled polydisperse emulsion-based digital loop-mediated isothermal amplification (deep-dLAMP) for label-free and low-cost nucleic acid quantification. This technology accurately predicts the occupancy status of each emulsion and provides measurements of nucleic acid concentrations. It significantly reduces instrument costs and has a wide range of potential applications.
Article
Chemistry, Analytical
Hongchao Gou, Qijie Lin, Haiyan Shen, Kaiyuan Jia, Yucen Liang, Junhao Peng, Chunhong Zhang, Xiaoyun Qu, Yanbin Li, Jianhan Lin, Jianmin Zhang, Ming Liao
Summary: A novel linear displacement isothermal amplification (LDIA) method was developed for specific gene detection, which has advantages of simple primer design, high sensitivity and specificity, and applicability for point-of-care testing (POCT).
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Nanoscience & Nanotechnology
Donglin Xu, Xiaodan Jiang, Tianli Zou, Guijun Miao, Qiang Fu, Fei Xiang, Liang Feng, Xiangzhong Ye, Lulu Zhang, Xianbo Qiu
Summary: A microfluidic system based on real-time convective PCR has been developed for rapid and automated nucleic acid extraction, amplification, and in-situ detection, demonstrating improved detection efficiency and accuracy.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Thermodynamics
Ke Wang, Xin-Xin Liu, Zu-Guo Shen, Huan-Huan Duan, Qun-Sheng Liu, Yan-Sheng Wu
Summary: The natural convective heat loss characteristics in isothermal cylindrical cavities were studied, and it was found that the heat loss is influenced by the aperture ratio and tilt angle. A strategy of controlling the air velocity to control the convective heat loss was proposed.
APPLIED THERMAL ENGINEERING
(2022)
Article
Virology
Wataru Yamazaki, Yasufumi Matsumura, Uraiwan Thongchankaew-Seo, Yasuko Yamazaki, Miki Nagao
Summary: The study has successfully developed a simple and rapid method for extracting RNA from saliva and conducting COVID-19 testing, which can be used in field settings to potentially reduce the risk of infection.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Chemistry, Analytical
Ya-Ling Tan, Hongjian Chen, Zhen-Kun Wu, Jianjun He, Jian-Hui Jiang
Summary: The study developed a sensitive HEADLAMP method based on HpaII for accurate detection of DNA methylation levels. Compared to traditional methods, HEADLAMP can more accurately detect low levels of DAPK1 methylation and show potential clinical applications in clinical tissue samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jyoti Jawla, Rajiv Ranjan Kumar, S. K. Mendiratta, R. K. Agarwal, Sarita Kumari, Vikas Saxena, Dhananjay Kumar, Praveen Singh, Nongthombam Boby, Preeti Rana
Summary: The study developed a rapid detection method for identifying cattle tissue with high specificity and analytical sensitivity. Laboratory validation and comparison with PCR detection methods demonstrated the accuracy of the developed assay. Additionally, the assay was shown to provide rapid results in field applications.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Rui Mao, Tianzuo Wang, Yue Zhao, Xinyao Wu, Shun Zhang, Ting Cai
Summary: The article presents a novel isothermal amplification method called closed dumbbell mediated isothermal amplification (CDA) for nucleic acids. The method offers the advantages of simple primer design, high amplification efficiency, and successful detection of virus genes and bacterial pathogens. Real-time and colorimetric CDA detection methods have also been developed and proven effective.
Article
Biophysics
Bin Zhang, Mingyu Chen, Jiasheng Cao, Yitao Liang, Tingting Tu, Jiahao Hu, Tianyu Li, Yu Cai, Shijie Li, Boqiang Liu, Junjie Xu, Bo Liang, Xuesong Ye, Xiujun Cai
Summary: The study presents a fully integrated electrochemical POCT platform using Au nanoflowers and PNA modification for circRNA detection, demonstrating low detection limit and high specificity, with good capability to handle one-base mismatch.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biotechnology & Applied Microbiology
Rui Mao, Xinyao Wu, Qing Miao, Ting Cai
Summary: Nucleic acid-based assays, such as Loop-mediated isothermal amplification (LAMP), have been widely used in clinical diagnostics, food safety, and environmental monitoring. A novel method called asymmetric stem-loop-mediated isothermal amplification (ASLAMP) was developed to overcome the challenges of specific primer design and non-specific amplification associated with LAMP. ASLAMP showed promising results in detecting the H1N1 gene fragment with simple primer design, short target sequence, and high amplification efficiency, offering potential for point-of-care DNA isothermal amplification.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Ravil R. Garafutdinov, Dmitry A. Chemeris, Assol R. Sakhabutdinova, Konstantin Moiseev, Said F. Urmancheev, Constantin Mikhaylenko, Lavrentyi Yu Privalov, Alexey Chemeris
Summary: Polymerase chain reaction (PCR) is widely used for nucleic acids amplification. This study reports the use of convective PCR (cPCR) in standard microtubes for efficient amplification of nucleic acids. By optimizing reaction conditions, high sensitivity detection and accumulation of amplification products were achieved, enabling reliable detection of SARS-CoV-2 coronavirus RNA from COVID-19 patients' nasopharyngeal swabs.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Guijun Miao, Meng Guo, Ke Li, Xiangzhong Ye, Michael G. Mauk, Shengxiang Ge, Ningshao Xia, Duli Yu, Xianbo Qiu
Summary: Convective PCR (CPCR) utilizes thermal convection to continuously drive reagent in a capillary tube, enabling spatially separate melting, annealing, and extending. By incorporating an FTA membrane filter, CPCR constructs a single reactor for both sample preparation and amplification. The system performance is optimized by analyzing critical issues such as wash scheme and reaction temperature.
Article
Biophysics
Jingjing Qian, Qinming Zhang, Meng Lu
Summary: In recent years, paper-based nucleic acid sensors have been used to detect DNA and RNA molecules extracted from viruses and bacteria. These sensors require the release of nucleic acids from lipid membranes and the removal of interfering molecules for accurate analysis. A portable sensor system has been developed to combine thermolysis and paper-based nucleic acid amplification tests (NAATs) for the detection of viral and exosomal RNA molecules. The system achieved quantitative analysis of influenza A virus (IAV) RNA and exosome microRNA within 1 hour, making it a promising point-of-care test for viral and bacterial infections.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Multidisciplinary
Khursheed Muhammad, T. Hayat, Alsaedi
Summary: This study focuses on mathematical modeling and analysis of mixed convection nanofluids flow around a stretching cylinder, with carbon nanotubes dispersed in water-based liquid as nanomaterial. The results show that fluid velocity increases with the rise in certain parameters, while temperature of the fluid varies with different parameters.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Immunology
Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T. Goodman, Nancy A. Hessol, Beatriz Grinsztejn, Ana P. Ortiz, Fanghui Zhao, Erna M. Kojic, Rupert Kaul, Isabelle Heard, Imran O. Morhason-Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M. Palefsky, Luana L. S. Rodrigues, Racheal S. Dube Mandishora, Reshmie A. Ramautarsing, Silvia Franceschi, Sheela Godbole, Fernanda K. Tso, Lynette J. Menezes, Chunqing Lin, Gary M. Clifford
Summary: Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections may persist longer, or occur later in life, in the anus than cervix. This has important implications for using cervical screening results to direct anal cancer prevention.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Feixue Wei, Marc T. Goodman, Ningshao Xia, Jun Zhang, Anna R. Giuliano, Gypsyamber D'Souza, Nancy A. Hessol, Maarten F. Schim van der Loeff, Jianghong Dai, Karin Neukam, Alexandra de Pokomandy, I. Mary Poynten, Ronald B. Geskus, Joaquin Burgos, Isabelle Etienney, Anna Barbara Moscicki, Maria Gabriella Dona, Maura L. Gillison, Alan G. Nyitray, Rebecca G. Nowak, Evy Yunihastuti, Huachun Zou, Carmen Hidalgo-Tenorio, Nittaya Phanuphak, Jean Michel Molina, Alice M. Schofield, Stephen Kerr, Song Fan, Yong Lu, Jason J. Ong, Admire T. Chikandiwa, Sirinya Teeraananchai, Nicola Squillace, Dorothy J. Wiley, Joel M. Palefsky, Damien Georges, Catharina J. Alberts, Gary M. Clifford
Summary: This study provides a comprehensive analysis of the natural history of anal high-risk HPV infection and identifies differences among different risk groups. These findings are crucial for designing effective anal cancer prevention programs.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Zihao Chen, Shaoqi Guo, Guanghui Li, Dong Ying, Guiping Wen, Mujin Fang, Yingbin Wang, Zimin Tang, Zizheng Zheng, Ningshao Xia
Summary: This study presents a design strategy for ORF2(S) expression and indicates that ORF2(S) (tPA) can be used for functional and structural studies of the HEV life cycle. The research also maps the functional antigenic sites in ORF2(S) candidates and demonstrates the antigenicity and immunogenicity of ORF2(S) (tPA).
Article
Engineering, Biomedical
Hao Li, Shengda Yu, Dong Wang, Xinying Huang, Qiang Fu, Donglin Xu, Lulu Zhang, Shizhi Qian, Xianbo Qiu
Summary: An automated microfluidic system with functionalized beads was developed for multiplexed TORCH detection. The system consists of a concise microfluidic chip, a liquid handling module, a ram pump, and a sensitive CMOS camera. Experimental results showed that efficient, sensitive, and accurate multiplexed TORCH detection can be conveniently achieved with this integrated microfluidic system.
BIOMEDICAL MICRODEVICES
(2022)
Review
Immunology
Wenhui Xue, Tingting Li, Ying Gu, Shaowei Li, Ningshao Xia
Summary: The global changes have led to the emergence and transmission of various biological factors, resulting in the rise of emerging and reemerging infectious diseases. The study highlights recent advancements in molecular biology, virology, and genomics that have facilitated the development of innovative molecular tools for vaccine research. The strategic application of advanced molecular engineering tools can overcome traditional vaccine limitations and enhance vaccine efficacy.
EXPERT REVIEW OF VACCINES
(2023)
Article
Computer Science, Interdisciplinary Applications
Dongxu Zhang, Yang Yan, Yulin Huang, Bowen Liu, Qingbing Zheng, Jun Zhang, Ningshao Xia
Summary: We proposed an iterative denoising and clustering method based on a deep convolutional variational autoencoder and K-means++ to improve the clustering accuracy of cryo-EM images. Experimental results showed that the proposed method can generate reliable class average images and achieve better clustering accuracy and normalized mutual information than current methods.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Review
Virology
Yang Shi, Zihan Wang, Shengxiang Ge, Ningshao Xia, Quan Yuan
Summary: The HBcAg is a highly immunogenic antigen and the anti-HBc is traditionally considered as a serological marker of HBV infections. However, recent studies have shown the predictive value of quantitative anti-HBc level in the treatment response and clinical outcome of chronic HBV infections. This review summarizes the clinical values of qAnti-HBc in differentiating CHB phases, predicting treatment response, and providing disease prognosis.
Article
Chemistry, Analytical
Yi-Quan An, Shao-Lei Huang, Bang-Chao Xi, Xiang-Lian Gong, Jun-Hao Ji, You Hu, Yi-Jie Ding, Dong-Xu Zhang, Sheng-Xiang Ge, Jun Zhang, Ning-Shao Xia
Summary: This article proposes a temperature control strategy to significantly increase the ramp rates of solution temperature by switching microfluidic chips between multiple temperature zones and increasing the temperature difference between zones and the solution. A thermocycler with ultrafast nucleic acid amplification capabilities has been designed. The results show that the ramp rates of solution temperature are linearly related to temperature differences, with larger differences resulting in faster ramp rates. The thermocycler achieves 92% reduction in nucleic acid amplification time compared to conventional methods.
Review
Microbiology
Mengling Hao, Jiabao Tang, Shengxiang Ge, Tingdong Li, Ningshao Xia
Summary: Herpesviruses are important pathogens that infect humans and animals. Bacterial artificial chromosome (BAC) technology has advanced the manipulation of herpesvirus genomes, but the efficiency still needs improvement. This review summarizes the advancements and limitations of BAC-based gene editing and its application in viral research.
Review
Immunology
Yarong Zeng, Feihong Zou, Ningshao Xia, Shaowei Li
Summary: Researchers have recognized the important role of Vaccine Adjuvant Delivery Systems (VADS) in vaccine research. This paper reviews common types of vaccine adjuvant delivery carriers, discusses current research status and future trends, and emphasizes the importance of VADS in novel vaccine research. Understanding various delivery vehicles will facilitate the development of vaccine adjuvant research.
EXPERT REVIEW OF VACCINES
(2023)
Article
Immunology
Yue Huang, Jiabao Tang, Huan Yu, Qiaoqiao Song, Mengling Hao, Han Wang, Junxian Liu, Yue Dong, Mufeng Liang, Sijie Zhuang, Caihong Li, Jiangding Wang, Caihong Liang, Yingying Su, Tingdong Li, Ting Wu, Shengxiang Ge, Jun Zhang, Ningshao Xia
Summary: This study examines the value of maternal CMV serological testing in predicting intrauterine transmission in regions with high seropositivity rates. The study found no statistical association between maternal IgM antibodies and IgG avidity during pregnancy and intrauterine transmission. The presence of CMV DNAemia indicated a higher risk of cCMV infection. However, the difference in CMV shedding rates in urine was not significant.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Letter
Biochemistry & Molecular Biology
Yizhen Wang, Feibo Song, Siling Wang, Miaolin Lan, Tingdong Li, Huilin Guo, Yali Zhang, Shengxiang Ge, Zizheng Zheng, Ningshao Xia
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemical Research Methods
Shaolei Huang, Yiquan An, Bangchao Xi, Xianglian Gong, Zhongfu Chen, Shan Shao, Shengxiang Ge, Jun Zhang, Dongxu Zhang, Ningshao Xia
Summary: Nucleic acid detection is a method that directly identifies the presence of pathogenic microorganisms and has advantages of high sensitivity, commendable specificity, and a short window period. A real-time PCR system based on multiple temperature zones was proposed to solve the time-consuming problem, enabling fast detection speed and high sensitivity under extreme conditions.
Article
Biochemical Research Methods
Zihao Chen, Nan Liu, Yang Huang, Xiaoping Min, Xiangxiang Zeng, Shengxiang Ge, Jun Zhang, Ningshao Xia
Summary: In this study, a protein docking evaluation method called PointDE is proposed, which utilizes a 3D point cloud neural network. PointDE is able to capture the geometry of the point cloud and learn the interaction information from the protein interface, showing superior performance on public datasets and an antibody-antigen dataset.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2023)
Article
Engineering, Electrical & Electronic
Yunan Han, Zhaohan Liu, Qiang Cui, Xianbo Qiu
Summary: This article presents a nesting cavities test method for determining the electromagnetic shielding effectiveness of enclosures on a PCB. The method is simple, efficient, accurate, and low-cost. The SE is determined by comparing the transfer parameter S21, and the results are verified through simulation and measurement.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
