Article
Cardiac & Cardiovascular Systems
Hirono Nishiyama, Yoshihiro Kanemitsu, Johsuke Hara, Kensuke Fukumitsu, Norihisa Takeda, Ryota Kurokawa, Keima Ito, Tomoko Tajiri, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: This study evaluated the efficacy of bronchial thermoplasty (BT) for cough in severe uncontrolled asthma. The results showed that BT significantly improved cough-related indices and cough sensitivity, especially in patients with cough-predominant symptoms. However, larger cohort studies are needed to confirm the effect of BT for cough in asthma.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Peter S. P. Cho, Hannah Fletcher, Irem S. Patel, Richard D. Turner, Caroline J. Jolley, Surinder S. Birring
Summary: Patients with COPD-chronic cough and CRC both exhibited heightened cough reflex sensitivity, but only those with CRC were unable to suppress capsaicin-evoked cough. This indicates differing mechanisms of cough between patients with COPD and CRC, highlighting the need for disease-specific approaches to management.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Audiology & Speech-Language Pathology
Carolyn K. Novaleski, Karen Wheeler Hegland, Mikala M. Aleksandruk, Pamela H. Dalton, Joel D. Mainland
Summary: The purpose of this study was to investigate whether healthy individuals demonstrate a quantifiable cough response after inhaling a volatile ester and if breath control techniques modify this chemically induced cough response. The results showed that 70% of participants experienced coughing after inhaling ethyl butyrate. Higher concentrations of ethyl butyrate resulted in stronger urge to cough and more coughing episodes. Breath control techniques significantly reduced the urge to cough. The study found that airborne ethyl butyrate serves as a tussigenic agent in humans.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2023)
Article
Allergy
Ryota Kurokawa, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Tomoko Tajiri, Hirono Nishiyama, Jennifer Maries Yap, Keima Ito, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: The study found that higher HARQ scores may be useful in predicting airway neuronal dysfunction in patients with asthma and are associated with worsening of asthma condition.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Allergy
Keima Ito, Yoshihiro Kanemitsu, Takeshi Kamiya, Kensuke Fukumitsu, Norihisa Takeda, Tomoko Tajiri, Ryota Kurokawa, Hirono Nishiyama, Jennifer Yap, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: This study examines the physiological relationships between severe uncontrolled asthma and functional gastrointestinal disorders (FGIDs). The results show that patients with comorbid FGIDs have higher levels of capsaicin cough sensitivity, a higher prevalence of gastroesophageal reflux disease, and may represent an important manifestation of the airway neuronal dysfunction phenotype of severe uncontrolled asthma.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Respiratory System
Jianmeng Zhou, Fang Yi, Feng Wu, Pusheng Xu, Meihua Chen, Huahao Shen, Lin Lin, Yunhui Zhang, Suyun Li, Changgui Wu, Yadong Yuan, Gang Wang, Xianwei Ye, Ping Zhang, Huaping Tang, Qianli Ma, Lanqing Huang, Zhongmin Qiu, Haiyan Deng, Chen Qiu, Guochao Shi, Jiayu Pan, Wei Luo, Kian Fan Chun, Nanshan Zhong, Kefang Lai
Summary: This study compared the clinical and pathophysiological characteristics of different phenotypes of asthma, and found differences in cough sensitivity and airflow obstruction between patients with cough predominant asthma and patients with cough variant asthma.
RESPIRATORY RESEARCH
(2022)
Article
Allergy
Freda Yang, John Busby, Liam G. Heaney, Andrew Menzies-Gow, Paul E. Pfeffer, David J. Jackson, Adel H. Mansur, Salman Siddiqui, Christopher E. Brightling, Robert Niven, Neil C. Thomson, Rekha Chaudhuri
Summary: This study aimed to identify factors associated with frequent exacerbations in severe asthma patients, and found that factors included ACQ-6 score, smoking history, and fractional exhaled nitric oxide levels. A high ACQ-6 score had the strongest association with frequent exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Neurosciences
Jaclyn A. Smith, Imran Satia, Huda Badri, Paul Marsden
Summary: In recent years, our understanding of the neurophysiological basis of cough has increased, as well as the concepts surrounding chronic coughing. Dysregulation of neuronal pathways mediating cough has been recognized to play a crucial role in certain phenotypes of chronic cough. This review aims to summarize current clinical evidence supporting the hyperexcitability of neuronal pathways contributing to chronic coughing and suggest their alignment with clinical features observed in patients.
NEUROSCIENCE LETTERS
(2023)
Article
Respiratory System
Esther Herrera-Luis, Angel C. Y. Mak, Javier Perez-Garcia, Elena Martin-Gonzalez, Celeste Eng, Kenneth B. Beckman, Scott Huntsman, Donglei Hu, Ruperto Gonzalez-Perez, Jose M. Hernandez-Perez, Elena Mederos-Luis, Yang Yie Sio, Paloma Poza-Guedes, Olaia Sardon, Paula Corcuera, Inmaculada Sanchez-Machin, Javier Korta-Murua, Carlos Martinez-Rivera, Joaquim Mullol, Xavier Munoz, Antonio Valero, Joaquin Sastre, Judith Garcia-Aymerich, Sabrina Llop, Maties Torrent, Maribel Casas, Jose R. Rodriguez-Santana, Jesus Villar, Victoria del Pozo, Fabian Lorenzo-Diaz, L. Keoki Williams, Erik Melen, Fook Tim Chew, Luisa N. Borrell, Esteban G. Burchard, Maria Pino-Yanes
Summary: This study used admixture mapping analyses and fine mapping to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups. The results showed limited transferability of these variants to other populations and their potential regulation of DPYSL3 and SCGB3A2 genes.
Article
Allergy
Jonathan M. Gaffin, Carter R. Petty, Ronald L. Sorkness, Loren C. Denlinger, Brenda R. Phillips, Ngoc P. Ly, Benjamin Gaston, Kristie Ross, Anne Fitzpatrick, Leonard B. Bacharier, Mark D. DeBoer, W. Gerald Teague, Sally E. Wenzel, Sima Ramratnam, Elliot Israel, David T. Mauger, Wanda Phipatanakul
Summary: This study aimed to identify phenotypic factors associated with FEV1 in children with asthma. The results showed that baseline FENO, response to triamcinolone acetonide, and bronchodilator reversibility were associated with FEV1. Additionally, age, obesity, and exacerbation frequency predicted FEV1 over time. There was also a significant interaction between age and sex, with boys experiencing more significant effects of exacerbation frequency on FEV1 compared to girls.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pediatrics
Laurel Teoh, Mark D. Chatfield, Jason P. Acworth, Gabrielle B. McCallum, Anne B. Chang
Summary: The study aimed to evaluate the determinants of prolonged cough and poorer quality of life questionnaires in children with asthma exacerbations during the recovery phase. Results showed that children on regular inhaled corticosteroids were more likely to have prolonged cough and poorer quality of life during recovery.
PEDIATRIC PULMONOLOGY
(2021)
Article
Physiology
Tissot Low, Chien-Hui Lee, Yen-Cheng Chen, Chun-Lan Lo, Ya-Chen Huang, Jyun-Yi Lin, Siao-Syuan Wu, Ching Jung Lai
Summary: The study found that prolonged mechanical ventilation can lead to decreased cough function, including lower cough reflex sensitivity and reduced cough strength of respiratory muscles.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Article
Allergy
Steven G. Kelsen, Ioana O. Agache, Weily Soong, Elliot Israel, Geoffrey L. Chupp, Dorothy S. Cheung, Wiebke Theess, Xiaoying Yang, Tracy L. Staton, David F. Choy, Alice Fong, Ajit Dash, Michael Dolton, Rajita Pappu, Christopher E. Brightling
Summary: The study evaluated the efficacy and safety of Astegolimab in patients with severe asthma, showing that the drug reduced asthma exacerbation rate and had a good effect on patients with low blood eosinophils, while maintaining safety and tolerability.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Isabella Annesi-Maesano, Lorenzo Cecchi, Benedetta Biagioni, Kian Fan Chung, Bernard Clot, Martine Collaud Coen, Gennaro D. Amato, Athanasios Damialis, Javier Dominguez-Ortega, Carmen Galan, Stefanie Gilles, Stephen Holgate, Mohamed Jeebhay, Stelios Kazadzis, Nikolaos G. Papadopoulos, Santiago Quirce, Joaquin Sastre, Fiona Tummon, Claudia Traidl-Hoffmann, Jolanta Walusiak-Skorupa, Pablo Alonso-Coello, Carlos Canelo-Aybar, Yahveth Cantero-Fortiz, David Rigau, Josefina Salazar, Francisca Verdugo-Paiva, Marek Jutel, Cezmi A. Akdis, Ioana Agache
Summary: This study aimed to investigate the impact of pollen exposure on asthma exacerbations and found that outdoor pollen exposure may have an effect on asthma exacerbation, particularly in children under 18 years of age. Further research is needed to evaluate the effects of pollen on asthma exacerbation, considering factors such as pollen sensitization, hay fever, air pollution, green spaces, and pre-existing medications, in order to improve preventive measures.
Review
Allergy
Nidhya Navanandan, Jonathan Hatoun, Juan C. Celedon, Andrew H. Liu
Summary: Accurate prediction of severe exacerbations in children with asthma is essential for reducing healthcare utilization, improving symptoms, and quality of life. Identified risk factors include demographic characteristics, asthma control, environmental exposures, inflammatory biomarkers, genetic polymorphisms, and other omic technologies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Yoshihiro Kanemitsu, Motohiko Suzuki, Kensuke Fukumitsu, Takamitsu Asano, Norihisa Takeda, Yoshihisa Nakamura, Yoshiyuki Ozawa, Ayako Masaki, Junya Ono, Ryota Kurokawa, Jennifer Yap, Hirono Nishiyama, Satoshi Fukuda, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Kenji Izuhara, Masaya Takemura, Akio Niimi
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Article
Allergy
Yoshihiro Kanemitsu, Ryota Kurokawa, Junya Ono, Kensuke Fukumitsu, Norihisa Takeda, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Jennifer Yap, Hirono Nishiyama, Ayako Masaki, Yoshiyuki Ozawa, Kenji Izuhara, Motohiko Suzuki, Akio Niimi
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2020)
Article
Allergy
Ryota Kurokawa, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Jennifer Maries Yap, Motohiko Suzuki, Yuta Mori, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: The FSSG questionnaire is useful for diagnosing GERD-related cough, especially in patients with low blood or sputum eosinophil counts. The sensitivity and specificity of the diagnosis can be increased in these patients, highlighting the utility of the subjective questionnaire in such cases.
Article
Allergy
Ryota Kurokawa, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Jennifer Maries Yap, Yoshiyuki Ozawa, Ayako Masaki, Junya Ono, Kenji Izuhara, Hirono Nishiyama, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Motohiko Suzuki, Akio Niimi
Summary: The study found that eosinophilic chronic rhinosinusitis and FeNO levels can serve as important biomarkers for predicting asthma symptoms following ESS in CRS patients. Some patients developed asthma symptoms post-surgery, with higher levels of sinus tissue eosinophils and FeNO. Changes in eosinophilic chronic rhinosinusitis and FeNO levels were significant post-ESS, but comparable between the groups.
Article
Allergy
Kensuke Fukumitsu, Hirono Nishiyama, Yoshihiro Kanemitsu, Norihisa Takeda, Ryota Kurokawa, Tomoko Tajiri, Keima Ito, Jenifer Maries Go Yap, Sayaka Yamamoto, Yoshitsugu Inoue, Satoshi Fukuda, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Motohiko Suzuki, Masaya Takemura, Akio Niimi
Summary: This study found that levels of CANO, but not FeNO50, predict changes in pulmonary function in ICS-naive asthmatics. Additionally, persistently high levels of CANO may be related to poor responsiveness to treatments assessed by Delta FEV1.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Ryota Kurokawa, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Tomoko Tajiri, Hirono Nishiyama, Jennifer Maries Yap, Keima Ito, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: The study found that higher HARQ scores may be useful in predicting airway neuronal dysfunction in patients with asthma and are associated with worsening of asthma condition.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Respiratory System
Yoshihiro Kanemitsu, Ryota Kurokawa, Taisuke Akamatsu, Kensuke Fukumitsu, Satoshi Fukuda, Yutaka Ito, Norihisa Takeda, Hirono Nishiyama, Keima Ito, Tomoko Tajiri, Yuta Mori, Takehiro Uemura, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Tetsuya Oguri, Toshihiro Shirai, Akio Niimi
Summary: The cough reflex sensitivity and blood eosinophil count are predictive risk factors for hospitalisation due to acute exacerbations of COPD or community-acquired pneumonia. Decreased capsaicin cough reflex sensitivity may play a role in the prevention of severe AE or pneumonia requiring hospitalisation.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Correction
Allergy
Hirono Nishiyama, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Ryota Kurokawa, Tomoko Tajiri, Keima Ito, Jenifer Maries Go Yap, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
ASIA PACIFIC ALLERGY
(2022)
Article
Allergy
Hirono Nishiyama, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Ryota Kurokawa, Tomoko Tajiri, Keima Ito, Jenifer Maries Go Yap, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: This study aimed to determine which definitions of severe uncontrolled asthma are associated with an additional treatment of biologics or bronchial thermoplasty. The results showed that poor asthma control, frequent exacerbations, and admissions were important factors for additional intensive treatment for severe uncontrolled asthma.
ASIA PACIFIC ALLERGY
(2022)
Review
Allergy
Ji-Hyang Lee, Sung-Yoon Kang, Youngsang Yoo, Jin An, So-Young Park, Ji-Ho Lee, Seung-Eun Lee, Min-Hye Kim, Yoshihiro Kanemitsu, Yoon-Seok Chang, Woo-Jung Song
Summary: Chronic cough is now considered a pathologic state characterized by deviation from the intrinsic protective functions of the cough reflex, with various factors underlying its reflex hypersensitivity and persistence. Researchers are exploring cough epidemiology using large population data and advancing research methodology to gain a deeper understanding of the disease pathophysiology.
ASIA PACIFIC ALLERGY
(2021)
Article
Respiratory System
Jennifer Maries Go Yap, Takashi Ueda, Yoshihiro Kanemitsu, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Testsuya Oguri, Shinya Ugawa, Akio Niimi
Summary: The study discovered that AITC has a protective effect on TGF-β1-induced α-SMA expression by activating the ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts, overcoming corticosteroid insensitivity. TRPA1 antagonists modulate the suppressive effect but do not completely prevent it. AITC and TRPA1 antagonists may serve as therapeutic agents for chronic respiratory diseases.
RESPIRATORY RESEARCH
(2021)