Article
Multidisciplinary Sciences
Definate Nhamo, Sinegugu Duma, Elizabeth Ojewole, Dixon Chibanda, Frances Cowan
Summary: This study aimed to understand the factors motivating female sex workers (FSWs) to initiate PrEP in Harare, Zimbabwe. The findings revealed that intrinsic motivators included self-protection from HIV infection and condom bursting, while external motivators included occupational risk, increased chance of offering unprotected sex, positive encouragement from others, the need to take care of children, prior participation in HIV prevention research, and gender-based violence.
Article
Immunology
Liem B. Luong Nguyen, Kenneth A. Freedberg, Sitima Wanjala, David Maman, Elisabeth Szumilin, Pierre Mendiharat, Yazdan Yazdanpanah
Summary: In a generalized HIV epidemic in Western Kenya, improving the care continuum from 90-90-90 to 95-95-95 is more effective than providing preexposure prophylaxis (PrEP). Continued improvement in the care continuum will have the greatest impact on decreasing new HIV infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Sinead Delany-Moretlwe, James P. Hughes, Peter Bock, Samuel Gurrion Ouma, Portia Hunidzarira, Dishiki Kalonji, Noel Kayange, Joseph Makhema, Patricia Mandima, Carrie Mathew, Elizabeth Spooner, Juliet Mpendo, Pamela Mukwekwerere, Nyaradzo Mgodi, Patricia Nahirya Ntege, Gonasagrie Nair, Clemensia Nakabiito, Harriet Nuwagaba-Biribonwoha, Ravindre Panchia, Nishanta Singh, Bekezela Siziba, Jennifer Farrior, Scott Rose, Peter L. Anderson, Susan H. Eshleman, Mark A. Marzinke, Craig W. Hendrix, Stephanie Beigel-Orme, Sybil Hosek, Elizabeth Tolley, Nirupama Sista, Adeola Adeyeye, James F. Rooney, Alex Rinehart, William R. Spreen, Kimberly Smith, Brett Hanscom, Myron S. Cohen, Mina C. Hosseinipour
Summary: The study aimed to assess the safety and efficacy of injectable cabotegravir compared with daily oral tenofovir diphosphate plus emtricitabine for HIV prevention in HIV-uninfected women. The results showed that cabotegravir was superior to TDF-FTC in preventing HIV infection among women.
Article
Multidisciplinary Sciences
Geetha Beauchamp, Sybil Hosek, Deborah J. Donnell, Kwun C. G. Chan, Brian P. Flaherty, Peter L. Anderson, Bonnie J. Dye, Nyaradzo Mgodi, Linda-Gail Bekker, Sinead Delany-Moretlwe, Connie Celum
Summary: This study developed an HIV prevention readiness measure to identify African adolescent girls and young women who are motivated to take pre-exposure prophylaxis (PrEP) and in need of adherence support. The measure showed good reliability and validity in assessing medication adherence and prevention readiness. These findings are important for the development and implementation of PrEP adherence support programs.
Article
Multidisciplinary Sciences
Rasheeta Chandler, Dominique Guillaume, Sherilyn Francis, Eric Xue, Kewal Shah, Andrea Parker, Natalie Hernandez
Summary: This study found that Black women had high levels of acceptability towards the HIV prevention app SavvyHER and used it moderately. The most frequently used features were live groups, viewing resources and educational information, and mental health monitoring, while pregnancy symptom monitoring and STI symptom monitoring features were less used. Women expressed their fondness of the app design and interface as it was reflective of the diversity of Black women.
Article
Public, Environmental & Occupational Health
Anne M. Presanis, Ross J. Harris, Peter Kirwan, Ada Miltz, Sara Croxford, Ellen Heinsbroek, Christopher H. Jackson, Hamish Mohammed, Alison E. Brown, Valerie C. Delpech, O. Noel Gill, Daniela De Angelis
Summary: This study estimated trends in HIV prevalence and undiagnosed HIV cases in England from 2013 to 2019, showing an increase in the total number of people living with HIV but a decrease in the number and proportion of undiagnosed cases. Steep declines in undiagnosed prevalence were observed in subgroups of gay, bisexual, and other men who have sex with men, as well as in most subgroups of Black African heterosexuals.
LANCET PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Raphael J. Landovitz, Deborah Donnell, Meredith E. Clement, Brett Hanscom, Leslie Cottle, Lara Coelho, Robinson Cabello, Suwat Chariyalertsak, Eileen F. Dunne, Ian Frank, Jorge A. Gallardo-Cartagena, Aditya H. Gaur, Pedro Gonzales, Ha V. Tran, Juan C. Hinojosa, Esper G. Kallas, Colleen F. Kelley, Marcelo H. Losso, J. Valdez Madruga, Keren Middelkoop, Nittaya Phanuphak, Breno Santos, Omar Sued, Javier Valencia Huamani, Edgar T. Overton, Shobha Swaminathan, Carlos del Rio, Roy M. Gulick, Paul Richardson, Philip Sullivan, Estelle Piwowar-Manning, Mark Marzinke, Craig Hendrix, Maoji Li, Zhe Wang, Jeanne Marrazzo, Eric Daar, Aida Asmelash, Todd T. Brown, Peter Anderson, Susan H. Eshleman, Marcus Bryan, Cheryl Blanchette, Jonathan Lucas, Christina Psaros, Steven Safren, Jeremy Sugarman, Hyman Scott, Joseph J. Eron, Sheldon D. Fields, Nirupama D. Sista, Kailazarid Gomez-Feliciano, Andrea Jennings, Ryan M. Kofron, Timothy H. Holtz, Katherine Shin, James F. Rooney, Kimberly Y. Smith, William Spreen, David Margolis, Alex Rinehart, Adeola Adeyeye, Myron S. Cohen, Marybeth McCauley, Beatriz Grinsztejn
Summary: The study showed that injectable Cabotegravir was more effective in preventing HIV infection among MSM and transgender women compared to daily oral Tenofovir Disoproxil Fumarate-Emtricitabine. Strategies are needed to prevent INSTI resistance in cases of Cabotegravir PrEP failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, Research & Experimental
Wilian Correa-Macedo, Vinicius M. Fava, Marianna Orlova, Pauline Cassart, Ron Olivenstein, Joaquin Sanz, Yong Zhong Xu, Anne Dumaine, Renata Hm Sindeaux, Vania Yotova, Alain Pacis, Josee Girouard, Barbara Kalsdorf, Christoph Lange, Jean-Pierre Routy, Luis B. Barreiro, Erwin Schurr
Summary: The study indicates that PLWH and those receiving ART have a weaker response to Mycobacterium tuberculosis compared to HIV-free individuals, with chromatin accessibility and transcriptional responsiveness of alveolar macrophages being more pronounced in the HC group.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Kate M. Mitchell, Dobromir Dimitrov, Romain Silhol, Lily Geidelberg, Mia Moore, Albert Liu, Chris Beyrer, Kenneth H. Mayer, Stefan Baral, Marie-Claude Boily
Summary: During the COVID-19 pandemic, reductions in HIV services for MSM in the USA could lead to increased new HIV infections, but this effect can be partially offset by maintaining lower sexual partner numbers. Initiations and adherence to ART are crucial for maintaining viral suppression and minimizing excess HIV-related mortality due to COVID-19 restrictions.
Article
Multidisciplinary Sciences
Ronald A. Brooks, Omar Nieto, Martin Santillan, Amanda Landrian, Anne E. Fehrenbacher, Alejandra Cabral
Summary: The additional benefits of using PrEP for Latino GBM include reduced fear and anxiety about HIV, feeling empowered to control their HIV risk, greater sexual risk behavior and sexual health awareness, more sexual exploration and pleasure, and a stronger connection to the community.
Article
Immunology
Maria Garcia-Cremades, Katarina Vucicevic, Craig W. Hendrix, Priya Jayachandran, Leah Jarlsberg, Robert Grant, Connie L. Celum, Michael Martin, Jared M. Baeten, Jeanne Marrazzo, Peter Anderson, Kachit Choopanya, Suphak Vanichseni, David Glidden, Radojka M. Savic
Summary: This study aimed to estimate the protective plasma concentration of tenofovir and found that high-risk women need higher levels of plasma tenofovir to prevent HIV acquisition than men.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Haisheng Wu, Qiuyan Yu, Liping Ma, Lin Zhang, Yuliang Chen, Pi Guo, Peng Xu
Summary: This study evaluated the health economics of antiretroviral-based strategies for HIV-serodiscordant couples in China, finding that antiretroviral interventions were more likely to provide clinical benefits but were difficult to improve quality of life. The current strategy of early ART was found to be the most cost-effective option.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Emily R. Bowman, Cheryl Cameron, Brian Richardson, Manjusha Kulkarni, Janelle Gabriel, Aaren Kettelhut, Lane Hornsby, Jesse J. Kwiek, Abigail Norris Turner, Carlos Malvestutto, Jose Bazan, Susan L. Koletar, Susanne Doblecki-Lewis, Michael M. Lederman, Mark Cameron, Nichole R. Klatt, Jordan E. Lake, Nicholas T. Funderburg
Summary: The study found that exposure of leukocytes to TDF or FTC in the context of PrEP resulted in decreased mitochondrial function and altered functional and transcriptional profiles. These findings may have important implications for the metabolic and immunologic consequences of PrEP in populations at risk for HIV acquisition.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Kelong Han, Paul Wannamaker, Hongzhou Lu, Biao Zhu, Meixia Wang, Melanie Paff, William R. Spreen, Susan L. Ford
Summary: Long-acting cabotegravir demonstrated safety, tolerability, and pharmacokinetic profile in Chinese adult men, indicating its potential as an effective option for HIV-1 preexposure prophylaxis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Parya Saberi, Marie C. D. Stoner, Kristin Ming, Nadra E. Lisha, J. Carlo Hojilla, Hyman M. Scott, Albert Y. Liu, Wayne T. Steward, Mallory O. Johnson, Torsten B. Neilands
Summary: The HIV preexposure prophylaxis optimization intervention study used a panel management intervention with PrEP coordinators and a web-based panel management tool to support healthcare providers in optimizing PrEP prescription and ongoing care. The study found that this intervention increased the number of PrEP prescriptions and improved PrEP-related counseling.