Review
Gastroenterology & Hepatology
Arjun Gandhi, Ayesha Shah, Michael P. Jones, Natasha Koloski, Nicholas J. Talley, Mark Morrison, Gerald Holtmann
Summary: The systematic review and meta-analysis indicated that methane-positive SIBO is more prevalent in IBS, particularly in IBS-C, compared to controls, while it is less common in patients with IBD. In patients with IBD, methane-positive SIBO was significantly lower in Crohn's disease compared to ulcerative colitis. More studies are needed to establish a causal relationship due to the low quality of evidence and clinical heterogeneity in the current studies.
Review
Cell Biology
Xin Feng, Xiao-Qing Li
Summary: This systematic review and meta-analysis found that the prevalence of SIBO in diabetic patients was 29%, and the risk of SIBO in diabetic patients was 2.91 times higher than that in patients without diabetes. The prevalence of SIBO in diabetes was higher in studies using jejunal aspirate culture for diagnosis and in studies conducted in Western countries.
Review
Gastroenterology & Hepatology
Ayesha Shah, Parag Thite, Teressa Hansen, Bradley J. Kendall, David S. Sanders, Mark Morrison, Michael P. Jones, Gerald Holtmann
Summary: This study found a link between small intestinal bacterial overgrowth (SIBO) and celiac disease (CeD) through a systematic review and meta-analysis. The prevalence of SIBO is higher in CeD patients, and antibiotic therapy for SIBO positive CeD patients leads to improvement in gastrointestinal symptoms.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Review
Medicine, General & Internal
Cristian-Ioan Babos, Daniel-Corneliu Leucuta, Dan Lucian Dumitrascu
Summary: This study assessed the effectiveness of meditation/mindfulness in improving symptoms severity, quality of life, and other associated mental conditions in patients with irritable bowel syndrome (IBS). The meta-analysis results showed statistically significant improvements in symptom score, quality of life, spiritual scale, and pain score in the mindfulness group compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Anna Gudan, Dominika Jamiol-Milc, Victoria Hawrylkowicz, Karolina Skonieczna-Zydecka, Ewa Stachowska
Summary: Bacterial overgrowth in the small intestine (SIBO) is associated with non-alcoholic fatty liver disease (NAFLD). This systematic review and meta-analysis found that the prevalence of SIBO in patients with chronic non-alcoholic liver diseases can be as high as 35%, and it increases with the percentage of men in the population. However, further research is needed due to the moderate to low quality of included studies and high heterogeneity.
Review
Gastroenterology & Hepatology
Ayesha Shah, Veenaa Pakeerathan, Michael P. Jones, Purna C. Kashyap, Kate Virgo, Thomas Fairlie, Mark Morrison, Uday C. Ghoshal, Gerald J. Holtmann
Summary: This systematic review and meta-analysis investigated the prevalence of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc), as well as the risk factors and the effects on gastrointestinal symptoms. The study found that SIBO prevalence in SSc patients is 39.9%, with a 10-fold increased prevalence compared to controls. It also suggested that antimicrobial therapy should be considered for SSc patients with SIBO and diarrhea.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Xiaoqing Li, Xin Feng, Zhongxiang Jiang, Zheng Jiang
Summary: This meta-analysis study found a strong association between SIBO and PD, with approximately half of PD patients testing positive for SIBO. These relationships significantly differed based on diagnostic test and geographic area.
Review
Medicine, General & Internal
Michelle Y. Nabi, Samal Nauhria, Morgan Reel, Simon Londono, Anisha Vasireddi, Mina Elmiry, Prakash V. A. K. Ramdass
Summary: The study aimed to estimate the pooled odds ratio of endometriosis and irritable bowel syndrome, and the pooled prevalence of irritable bowel syndrome in patients with endometriosis. The results showed that patients with endometriosis have a threefold increased risk of developing irritable bowel syndrome, and the prevalence of irritable bowel syndrome in women with endometriosis was 23.4%.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Gianluca Ianiro, Judy Nee, Anthony J. Lembo, Paul Moayyedi, Christopher J. Black, Alexander C. Ford
Summary: This study aimed to evaluate the efficacy and safety of peppermint oil in the treatment of IBS. The results showed that peppermint oil was more effective than placebo, but adverse events occurred more frequently.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Review
Immunology
Tao Zhang, Cunzheng Zhang, Jindong Zhang, Feng Sun, Liping Duan
Summary: This network meta-analysis found that B.coagulans exhibited significant efficacy in treating IBS patients, L.plantarum ranked first in improving quality of life, and L.acidophilus had the lowest incidence of adverse events. Treatment length significantly influenced the efficacy of probiotics in improving abdominal pain and straining.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
David J. Cangemi, Brian E. Lacy, Journey Wise
Summary: This study found poor agreement between lactulose breath test (LBT) and duodenal aspiration (DA) in the evaluation of small intestinal bacterial overgrowth (SIBO). LBT may be more favorable than DA due to being safer, cheaper, and less likely to yield a contaminated result. Patients with diabetes mellitus or proton pump inhibitor (PPI) use were more likely to have a positive result in DA, while those with a history of small bowel resection were more likely to have a positive result in LBT.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. Quigley
Summary: The concept of SIBO has undergone significant changes and challenges, with uncertainty and controversy surrounding its diagnosis. This review aims to discuss the current pathophysiology of SIBO.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2021)
Review
Rheumatology
Xin Feng, Xiao-Qing Li, Zheng Jiang
Summary: The prevalence of SIBO is high in SSc patients, and diarrhea may be a predictor. Antibiotic therapy is effective in treating SIBO in SSc patients.
CLINICAL RHEUMATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Erin R. Shanahan, Seungha Kang, Heidi Staudacher, Ayesha Shah, Anh Do, Grace Burns, Veronique S. Chachay, Natasha A. Koloski, Simon Keely, Marjorie M. Walker, Nicholas J. Talley, Mark Morrison, Gerald J. Holtmann
Summary: This study indicates a link between duodenal microbiota, gastric emptying, and FD symptoms, and this link is largely independent of long-term dietary intake.
Article
Gastroenterology & Hepatology
Natasha A. Koloski, Michael Jones, Marjorie M. Walker, Michael Horowitz, Gerald Holtmann, Nicholas J. Talley
Summary: Diabetes is an independent risk factor for an increased frequency of gastrointestinal symptoms, adjusting for lifestyle and psychological factors.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Letter
Gastroenterology & Hepatology
Ahmad H. Ali, Cynthia W. Buness, Ryan Fischer, Gerald J. Holtmann, Ayesha Shah, Peter Lewindon, Shamita Shah, Amol S. Ragnekar, Amy E. Taylor, Aparna Goel, Kenneth L. Cox, Leina Alrabadi, Steve Wadsworth, Sakil S. Kulkarni, Keith D. Lindor
Review
Gastroenterology & Hepatology
Michael P. Jones, Gerald Holtmann
Summary: Placebo responses provide insights into mechanisms beyond the intervention and affect the potential efficacy of new interventions in clinical trials. This mini-review discusses the systematic review and meta-analysis conducted by Bosman and colleagues on placebo response in functional dyspepsia clinical trials. It also explores potential mechanisms of placebo response in the context of brain-gut interaction disorders and extra-gastrointestinal disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Adam I. I. Kaplan, Yoav Mazor, Gillian M. M. Prott, Carol Sequeira, Michael P. Jones, Allison Malcolm
Summary: Recent community-based studies have found that having multiple concurrent functional gastrointestinal disorders (FGIDs) is associated with increased somatization, worse quality of life (QoL), and greater healthcare utilization. However, the presence of multiple overlapping FGIDs specifically in chronic constipation and functional defecation disorders (FDD) has not been studied. This study investigated the prevalence and impact of additional nonconstipation FGIDs on constipation severity, anorectal physiology, anxiety and depression, and QoL in patients with chronic constipation and FDD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Nick Goelen, Mike Jones, I-Hsuan Huang, Florenca Carbone, Pieter Janssen, Jan Tack
Summary: Gastroparesis and functional dyspepsia are disorders characterized by upper gastrointestinal symptoms and multifaceted etiologies. The association between symptom improvement and acceleration of gastric emptying (GE) by prokinetic agents is not clear. This meta-analysis aimed to provide a transparent update on the association between symptom improvement and GE acceleration in patients with gastroparesis.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Samuel Chan, Carmel M. M. Hawley, Elaine M. M. Pascoe, Christopher Cao, Katrina L. L. Campbell, Scott B. B. Campbell, Ross S. S. Francis, Rachael Hale, Nicole M. M. Isbel, Mark Morrison, David W. W. Johnson
Summary: This study aims to assess the feasibility of prebiotic supplementation in reducing infections and gastrointestinal symptoms in kidney transplant recipients. Sixty recipients will be recruited for a double-blind, placebo-controlled, randomised trial to receive prebiotic therapy or placebo for 4-6 weeks. The outcomes will include recruitment, adherence, tolerance, laboratory parameters, quality of life, gastrointestinal symptoms, and clinical outcomes.
PILOT AND FEASIBILITY STUDIES
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Uday C. Ghoshal, Gerald J. Holtmann
Summary: The aim of this review is to summarize the current and emergent approaches to characterize the small intestinal microbiota and discuss the treatment options for management of small intestinal bacterial overgrowth (SIBO). This review captures the growing body of evidence for the role of SIBO, a type of small intestinal dysbiosis in the pathophysiology various gastrointestinal and extraintestinal disorders. Although recurrence is common, targeted modulation of the gut microbiome as a therapeutic option for management of SIBO is associated with improvement in symptoms and quality of life.
CURRENT OPINION IN GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Ali Eqbal, Naomi Moy, Natasha Koloski, Helmut Messmann, Bradley J. Kendall, Prateek Sharma, Uwe Dulleck, Michael P. Jones, Gerald J. Holtmann
Summary: This study aimed to determine the prevalence of upper gastrointestinal (UGI) lesions in subjects with a positive fecal occult blood test (FOBT+). The results showed that the prevalence of UGI cancers in FOBT+ subjects was 0.8%, and the prevalence of UGI clinically significant lesions (CSLs) was 30.4%. Anemia was associated with UGI cancers and UGI CSLs, while gastrointestinal symptoms were not associated with UGI CSLs.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Immunology
Md. Al Amin Sikder, Ridwan B. Rashid, Tufael Ahmed, Ismail Sebina, Daniel R. Howard, Md. Ashik Ullah, Muhammed Mahfuzur Rahman, Jason P. Lynch, Bodie Curren, Rhiannon B. Werder, Jennifer Simpson, Alec Bissell, Mark Morrison, Carina Walpole, Kristen J. Radford, Vinod Kumar, Trent M. Woodruff, Tan Hui Ying, Ayesha Ali, Gerard E. Kaiko, John W. Upham, Robert D. Hoelzle, Paraic O. Cuiv, Patrick G. Holt, Paul G. Dennis, Simon Phipps
Summary: Poor maternal diet during pregnancy increases the risk of severe lower respiratory infections (sLRIs) in infants. This study found that a maternal low-fiber diet (LFD) led to worsened LRI severity in mice offspring due to delayed recruitment of plasmacytoid dendritic cells (pDC) and disruption of regulatory T cell expansion in the lungs. The LFD altered the composition of the maternal milk and infant gut microbiome, resulting in reduced secretion of the DC growth factor Flt3L and impaired pDC hematopoiesis. However, therapy with propionate-producing bacteria or propionate supplementation restored gut Flt3L expression and pDC hematopoiesis, providing protection against sLRI.
Article
Veterinary Sciences
Leandro Abreu da Fonseca, Fabiano Montiani-Ferreira, Jeny Soto, Michael P. Jones, Nancy Zagaya, Carolyn Cray
Summary: This study compared agarose gel electrophoresis (AGE) and capillary zone electrophoresis (CZE) methods and determined reference intervals for CZE using plasma from bald eagles. The results showed that these two methods are not equivalent, and CZE demonstrated better resolution and reproducibility for protein fraction quantitation.
VETERINARY CLINICAL PATHOLOGY
(2023)
Review
Gastroenterology & Hepatology
Uday C. Ghoshal, Ujjala Ghoshal, Ayesha Shah, Gerald Holtmann
Summary: There is a significant interest in gut microbiota dysbiosis, specifically small intestinal bacterial overgrowth (SIBO), however, the current diagnostic methods for SIBO are not satisfactory. This review discusses the different invasive and noninvasive tests for diagnosing SIBO, their methodology, interpretation, sensitivity, specificity, and limitations. It also presents potential methods for diagnosis of SIBO that may be useful in clinical practice in the future.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Veenaa Pakeerathan, Michael P. Jones, Purna C. Kashyap, Kate Virgo, Thomas Fairlie, Mark Morrison, Uday C. Ghoshal, Gerald J. Holtmann
Summary: This systematic review and meta-analysis investigated the prevalence of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc), as well as the risk factors and the effects on gastrointestinal symptoms. The study found that SIBO prevalence in SSc patients is 39.9%, with a 10-fold increased prevalence compared to controls. It also suggested that antimicrobial therapy should be considered for SSc patients with SIBO and diarrhea.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Psychiatry
Anastasia Ejova, Michael P. Jones, Alissa P. Beath, Sarah L. Mckerchar, Akiko Okifuji
Summary: There is evidence that people with both fibromyalgia and functional gastrointestinal disorders experience more severe psychological symptoms. Using Ecological Momentary Assessment (EMA), this study found that for individuals with fibromyalgia, accompanying GI symptoms lead to stronger bidirectional relationships between distress and bodily pain or fatigue.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
