Article
Oncology
JinHui Liu, ChengJian Ji, Yichun Wang, Cheng Zhang, HongJun Zhu
Summary: Through analysis of UCEC patient data, 3 differential methylation-driven genes (DMDGs) were identified as predictors of poor prognosis in UCEC, leading to the establishment of an independent prognostic index (MDS) and a new prognostic scoring system based on MDS. GSEA analysis suggested a potential association between the heterogeneity of patient prognosis and immune-related pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Hui Yao, Xiya Jiang, Hengtao Fu, Yinting Yang, Qinqin Jin, Weiyu Zhang, Wujun Cao, Wei Gao, Senlin Wang, Yuting Zhu, Jie Ying, Lu Tian, Guo Chen, Zhuting Tong, Jian Qi, Shuguang Zhou
Summary: This study identified six immune-related lncRNAs for prognostic prediction of cervical cancer (CC) and constructed an immune-related risk model. High-risk groups were associated with poor survival outcomes, and risk scores were influenced by clinicopathological parameters and tumor stage. The immune-related signatures were linked to various immune cells in the inflammatory microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Jia He, Yun Zhong, Yanli Sun, Chao Xie, Tianqiang Yu
Summary: This study screened candidate prognosis-related genes of ccRCC by analyzing the TME, established a prognostic risk model, and identified 7 immune-related signature genes through regression analysis. The results contribute to understanding the impact of TME on patient prognosis and progression of ccRCC, as well as potential biomarkers.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Immunology
Guang Zhao, Dingli Song, Jie Wu, Sanhu Yang, Sien Shi, Xiaohai Cui, Hong Ren, Boxiang Zhang
Summary: The study suggests that OTUD6B is an oncogene and may serve as a new potential biomarker in various tumors. OTUD6B may play a part in the tumor immune microenvironment (TIME), which could be applied as a new target for cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Hongmei Gu, Jiahang Song, Yizhang Chen, Yichun Wang, Xiaofang Tan, Hongyu Zhao
Summary: This study identified two inflammation-related subtypes in UCEC patients, discovered potential prognostic IRLs, and established a risk model. The IRLPS was found to be valuable in predicting the clinical outcomes of UCEC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Yanze Yin, Yi Luo, Kang He
Summary: This study analyzed the relationship between immune infiltration and gene expression profile in hepatocellular carcinoma (HCC) using public databases. The results revealed the clinical and prognostic implications of immune cells in HCC. Key immune-related genes were identified and correlated with immune cells in HCC. These findings provide valuable insights into the mechanisms of immune cells in HCC and contribute to the development of new prognostic strategies.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Immunology
Yibo Dai, Luyang Zhao, Dingchao Hua, Lina Cui, Xiaobo Zhang, Nan Kang, Linlin Qu, Liwei Li, He Li, Danhua Shen, Zhiqi Wang, Jianliu Wang
Summary: This study comprehensively deciphered the immunological features of different molecular subtypes of endometrial cancer. The TMB-H subtype showed a high degree of infiltration of CD8(+) T cells. In the NSMP subtype, the overall degree of intra-tumoral infiltrating immune cells was low. In the TP53 mutant subtype, the densities of both PD-L1(+) macrophages and PD-1(+) T cells in tumor parenchyma were the highest among the four subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yuxuan Song, Yiqing Du, Caipeng Qin, Haohong Liang, Wenbo Yang, Jiaxing Lin, Mengting Ding, Jingli Han, Tao Xu
Summary: Through analyzing large-scale sequencing data, we identified CAV1, COL6A2, FABP4, FBLN1, PCOLCE, and CSPG4 as critical genes in gemcitabine-resistant bladder cancer (BCa). These genes regulate the infiltration of tumor-infiltrating immune cells and are significantly associated with overall survival in BCa. Additionally, microRNAs play important regulatory roles in gemcitabine resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yuanyuan Wang, Wei Li, Xiaojing Jin, Xia Jiang, Shang Guo, Fei Xu, Xingkai Su, Guiqi Wang, Zengren Zhao, Xiaosong Gu
Summary: In this study, a novel thirteen immune-related genes signature was established as a validated prognostic predictor for CRC patients, which may assist in individualized treatment decisions.
Article
Genetics & Heredity
Xuewei Xing, Yanan Tian, Xuan Jin
Summary: This study identified necroptosis-related genes associated with cervical cancer and constructed a prognostic model for evaluating patients' risk of poor prognosis. The results showed that these genes are closely related to the development and immune environment of cervical cancer, providing new targets for future treatment.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Yingrong Shi, Si Chen, Huijuan Xing, Guanglie Jiang, Nan Wu, Qiannan Liu, Norihiro Sakamoto, Takayoshi Kuno, Reiko Sugiura, Qinghuan Xiao, Feng Jin, Yue Fang, Fan Yao
Summary: Recent studies have shown that the tumor microenvironment plays a crucial role in breast cancer development, progression, and therapeutic response. The immune/stromal/ESTIMATE scores calculated by the ESTIMATE algorithm can reflect the tumor microenvironment. This study analyzed the correlation between immune/stromal/ESTIMATE scores and invasive breast cancer prognosis, and identified high-frequency differential expression genes (HF-DEGs) associated with the tumor microenvironment that have prognostic value. The results suggest that these HF-DEGs may serve as potential biomarkers and therapeutic targets for invasive breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Shi-Wei Guan, Quan Lin, Xi-Dong Wu, Hai-Bo Yu
Summary: The study suggests that there is an association between the tumor microbiome and the tumor genome, and this association is not accidental and could change the landscape of tumor research.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yizhou Huang, Lizhi Chen, Ziyi Tang, Yu Min, Wanli Yu, Gangyi Yang, Lili Zhang
Summary: By analyzing data from the TCGA database, the study identified ITK as a potential indicator for prognosis prediction in patients with breast cancer, and its expression was associated with immune activity in the tumor microenvironment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang Jiao, Rui Geng, Zihang Zhong, Senmiao Ni, Wen Liu, Zhiqiang He, Shilin Gan, Qinghao Huang, Jinhui Liu, Jianling Bai
Summary: Four hypoxia-related genes were used to develop a prognostic model for endometrial cancer. NR3C1 amplification and IL-6 and SRPX suppressions were found in tumors. The high-risk group showed high stromal score and enriched infiltrated aDCs and B cells, supporting the hypothesis of an immune-deserted tumor. Hypoxia-related molecular subtypes of EC were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Fangyun Gu, Fang Xu, Zimeng Pan, Lin Shi, Jinglu Yu, Feifei Song, ShuFeng Huang, Miao Sun
Summary: This study found that low density lipoprotein receptor-related protein 11 (LRP11) is highly expressed and acts as a risk prognostic factor in cervical cancer and various tumors. LRP11 is involved in multiple tumor malignant pathways and has a unique relationship with tumor immune microenvironment. Additionally, high expression of LRP11 is associated with drug resistance to various anti-tumor drugs.
Article
Engineering, Mechanical
Xiaohui Liu, Jian Song, Liangyao Yu, Zhenghong Lu, Jinzhen Wang, Lanie Abi
Summary: This paper focuses on improving both brake safety and ride comfort in the postbraking phase. By establishing a complete vehicle model and designing a safety control strategy, braking safety is ensured through the collection of driver behavior and vehicle signals. A sliding mode control algorithm is used to propose a methodology for longitudinal deceleration control, aiming to enhance ride comfort while reducing the braking distance.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART D-JOURNAL OF AUTOMOBILE ENGINEERING
(2023)
Article
Clinical Neurology
Suiyong Du, Panpan Hu, Shaomin Yang, Hongqing Zhuang, Feng Wei, Xiaoguang Liu, Zhongjun Liu
Summary: This retrospective cohort study described the surgeries and treatment outcomes of metastatic pheochromocytomas and paragangliomas on the spine. The study found that surgery is effective for treating intractable local pain and neurological impairment in these patients. Palliative surgical strategies can achieve relatively good treatment outcomes, especially for patients in poor physical conditions.
GLOBAL SPINE JOURNAL
(2023)
Article
Cell Biology
Run-Qi Guo, Jin-Zhao Peng, Yuan-Ming Li, Xiao-Guang Li
Summary: The study confirms that the systemic antitumor immunity can be enhanced by combining microwave ablation with anti-PD-1/CTLA-4 treatment in renal cell carcinoma.
Article
Chemistry, Multidisciplinary
Xinning Han, Xuerui Liu, Shuye Li, Zhenliang Li
Summary: A high stable and efficient CuO@CSs catalyst was prepared through in-situ growth methods, which showed good capability in activating peroxymonosulfate (PMS). Under UV-visible light irradiation, the CuO@CSs/PMS system exhibited high degradation efficiency towards RhB, and the catalyst could be reused. The generation of both 1O2 and O2·- in the photocatalytic process was confirmed to contribute to the removal of RhB. Moreover, the CuO@CSs/PMS system also showed excellent degradation performance for RhB in natural water samples.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2023)
Article
Geochemistry & Geophysics
Mengtao Chen, Guoxin Chen, Wencai Yang
Summary: This paper introduces a news processing method for geomagnetic anomaly field data, called the envelope mode magnetic field, which can weaken the influence caused by geomagnetic polarity reversal during rock magnetization, reflect the magnetic change of crustal rocks, and locate the crustal structures. Simulation tests and experiments confirm the effectiveness of this method.
Article
Geochemistry & Geophysics
Jiao Tian, Xiaocheng Zhou, Yucong Yan, Miao He, Jingchao Li, Jinyuan Dong, Fengli Liu, Shupei Ouyang, Ying Li, Lei Tian, Yingchun Wang, Tianming Huang, Zhonghe Pang
Summary: The study investigated hot springs along the Anninghe-Zemuhe Fault on the eastern edge of the Tibetan Plateau. The results showed that earthquake activities play a significant role in both spatial and temporal changes in the hydrochemical compositions of hot springs. The findings provide insights into the hydrochemical response to earthquakes in orogenic areas.
APPLIED GEOCHEMISTRY
(2023)
Review
Engineering, Environmental
Xiaohua Zhang, Ruyun Han, Yanzhen Liu, Hengxiang Li, Wenjing Shi, Xiaoyan Yan, Xinxin Zhao, Yongfeng Li, Baosheng Liu
Summary: This review summarizes the recent progress in the preparation methods of biomass-based porous graphitic carbon (BPGC), including activation, catalytic graphitization, and simultaneous activation-graphitization. The mechanisms of structure evolution during activation and graphitization are highlighted. The advances in optimizing and restructuring the microstructure of BPGC from 0D to 3D are presented. The structure-performance correlation of BPGC for supercapacitors is discussed, along with the challenges and opportunities for its further development in energy storage.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Lijiao Chen, Yang Gao, Mingchen Ma, Lili Wang, Qinglu Wang, Shuhui Guan, Xiaohong Yao, Huiwang Gao
Summary: Biomass burning has significant impacts on air quality and climate, particularly in areas with agricultural burning. However, the uncertainties in biomass burning emissions, especially in agricultural burning, limit our understanding of their effects on air quality. By using an improved emission inventory and satellite data, this study evaluates the impact of biomass burning on air quality and climate in Northeast China and finds that biomass burning contributes significantly to PM2.5 concentrations in the region. The study also highlights the importance of small fires, often missed in traditional satellite products, in affecting air quality.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Aerospace
Ran Wang, Mingjie Yu, Yue Bai, Liang Yu, Guangming Dong
Summary: This paper proposes a method for broadband acoustic modal identification based on nonsynchronous measurements from a rotating microphone array, which solves the problem of acoustic modal aliasing caused by a limited number of microphones. The method uses a single reference microphone to enhance the robustness of cross-spectral matrix completion. The accuracy of the method is verified through numerical simulations and experimental results from an axial flow compressor.
Article
Agricultural Engineering
Lili Wang, Kai Sun, Shuai Pan, Shunli Wang, Zhongkang Yan, Lianlian Zhu, Xingyuan Yang
Summary: This study aimed to explore the effect of antagonism between Trichoderma reesei (T.r) and Phanerochaete chrysosporium (P.c) on humification during fermentation of rice straw (RS) and canola straw (CS). The results showed that the addition of exogenous fungi accelerated straw degradation and enzyme activities. P.c inhibited the activity of LiP when co-existing with T.r, but promoted lignin degradation and the production of humus-like substances (HLS) and humic-like acid (HLA) in later fermentation. The recommended technology for converting crop straw into humus resources was RTP.
BIORESOURCE TECHNOLOGY
(2023)
Article
Environmental Sciences
Lili Wang, Lianlian Zhu, Shuai Pan, Shunli Wang
Summary: Chinese university campuses, accommodating over 30 million students, contribute to high carbon emissions due to the consumption of fossil fuel energy. This study explores the potential of biomethane production from food waste through anaerobic digestion in 2344 universities across 353 cities in mainland China. The results indicate that campus canteens annually generate 1.74 million tons of food waste, with a biomethane potential of 195.8 million m3, leading to a reduction of 0.77 million tons of CO2-eq. Wuhan, Zhengzhou, and Guangzhou are identified as the cities with the highest biomethane potential. The challenges include the purity of food waste, accumulation of ammonia and fatty acids, foaming, and appropriate plant site selection. By addressing these technical and management challenges, low-carbon campuses can be achieved through the utilization of bioenergy such as biomethane.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Jing Qi, Xiaoli Wang, Lin Fan, Shuhan Gong, Xinqi Wang, Chong Wang, Li Li, Hang Liu, Yun Cao, Mengmeng Liu, Xu Han, Liqin Su, Xiaoyuan Yao, Mats Tysklind, Xianliang Wang
Summary: Household dust is a significant source of premature exposure to PBDEs, particularly for children. This onsite study collected 246 dust samples from 224 households in nine Chinese cities and explored the association between household-related information and PBDEs in household dust. The study found that temperature, CO2 levels, years of residence, income, family size, household size, use of computers, heating, use of insecticide, and use of humidifiers were influential factors on PBDE concentrations in household dust. The results provide a basis for controlling PBDE pollution in Chinese households and protecting population health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Gastroenterology & Hepatology
Chenhong Lin, Yeda Chen, Feng Zhang, Peng Zhu, Liangliang Yu, Wenbiao Chen
Summary: This study revealed that cancer-associated fibroblasts (CAFs) are closely associated with hepatocarcinogenesis. CAFs can be divided into three subclasses, and CAF2 is specifically related to the clinical information of hepatocellular carcinoma (HCC). CAFs have strong interactions with B cells and CD8+ T cells, and PTN is identified as a novel mediator of CAFs in modulating hepatitis B virus (HBV) cirrhosis-HCC progression.
Article
Engineering, Electrical & Electronic
Liang Yu, Huimin Liu, Ning Chu, Ali Mohammad-Djafari, Weihua Yang
Summary: This paper presents a measurement principle for three-dimensional non-synchronous measurements with a central reference based on revolution and autorotation. By combining revolution and autorotation, the spatial resolution is improved and the side lobe interference is reduced.
IEEE SIGNAL PROCESSING LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Wenbin Wang, Xiangping Yu, Yinjun Zhao, Long Li, Yuwen Li, Yingzhong Tian, Fengfeng Xi
Summary: This paper presents a simplified approach to efficiently solve the inverse kinematics of a flexible panel continuum robot. Through an experiment, two approximate relationships are discovered: the arc length of the middle backbone can be estimated from the arc lengths of the two panels, and the length difference between the two panels can be related to the tip angle of the end-effector. Based on these relationships, a simplified inverse kinematics method is proposed using a constant curvature model. The method has been validated with high accuracy, demonstrating its effectiveness for real-time applications.
