Journal
AGEING RESEARCH REVIEWS
Volume 58, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2019.101004
Keywords
Neuropsychiatric symptoms; Mild cognitive impairment; Dementia; Neuropsychiatric inventory; Neuropsychiatric inventory questionnaire; Meta-analysis
Categories
Funding
- FEDER [PSI2014-55316-C3-1-R]
- National Research Agency (Spanish 'Ministry of Science, Innovation and Universities) [PSI2017-89389-C2-1-R]
- Galician Government (Consellerfa de Cultura, Educacion e Ordenacion Universitaria
- axudas para a consolidacion e estruturacion de unidades de investigacion competitivas do Sistema Universitario de Galicia) [GI-1807-USC, ED431-2017/27]
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Background Neuropsychiatric Symptoms (NPS) are common in Mild Cognitive Impairment (MCI). The Neuropsychiatric Inventory (NPI) and its shorter version, the Neuropsychiatric Inventory Questionnaire (NPI-Q), are the most common measures to assess NPS. Our objective was to determine if NPI/NPI-Q ratings predict conversion from MCI to dementia. Methods: Empirical longitudinal studies published in English or Spanish, concerned with the role of NPS as a risk factor for conversion from MCI to dementia, with a diagnosis of MCI following clinical criteria, that reported NPI/NPI-Q total score in converters versus non-converters, were included. Random effects models were used, and heterogeneity was explored with stratification and a random-effects meta-regression. The overall conversion rate and the standardized mean difference (SMD) for evolution, as a function of NPI/NPI-Q scores, were calculated. Results: The overall conversion rate was 35 %. Mean NPI/NPI-Q ratings were higher in converters versus in non converters, with the overall SMD approaching significance. Heterogeneity was observed in studies of more than two years of follow-up and in a study with a mean age of more than 80 years. This heterogeneity concerned the size, not the direction of the difference. Conclusions: Our results suggest that NPI/NPI-Q ratings are associated with conversion from MCI to dementia.
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