Article
Biophysics
Julian Echave
Summary: In monomeric enzymes, the range of evolutionary coupling varies widely due to different functional selection pressures. Furthermore, the evolutionary coupling range does not necessarily correspond to the short-range physical coupling present in all enzymes.
BIOPHYSICAL JOURNAL
(2021)
Review
Geriatrics & Gerontology
Elena Munoz-Redondo, Andrea Morgado-Perez, Maria Jose Perez-Saez, Julio Pascual, Marta Tejero-Sanchez, Yulibeth G. Curbelo, Marc Terradellas-Fernandez, Delky Meza-Valderrama, Olga Vazquez-Ibar, Cedric Annweiler, Dolores Sanchez-Rodriguez, Ester Marco
Summary: This review provides an overview of frailty, including its epidemiology, screening and diagnostic tools, and new perspectives based on global frameworks. Frailty is a significant health challenge worldwide, affecting older adults and those with chronic diseases regardless of age. Although various screening and diagnostic tools exist, none have proven superior in all populations and healthcare settings. Frailty encompasses physical, cognitive, and social components, and the use of validated tools tailored to specific populations and healthcare systems is recommended. Unintentional weight loss is a common criterion for both physical frailty and malnutrition, while sarcopenia shares criteria of low muscle function and physical performance. Intrinsic capacity, a person-centered and public health indicator, focuses on the positive aspects of aging and aims to promote healthier aging in the Decade of Healthy Aging 2020-2030.
Article
Geriatrics & Gerontology
Tereza Vagnerova, Helena Michalkova, Olga Dvorackova, Eva Topinkova
Summary: This study compares the performance of diagnostic criteria for sarcopenia (EWGSOP1 and EWGSOP2) and develops a more precise algorithm for detecting sarcopenic obesity (SO). The results suggest that EWGSOP1 criteria have higher sensitivity than EWGSOP2 in identifying patients with sarcopenia and SO. The proposed diagnostic algorithm model can increase the sensitivity of SO diagnosis and is simple to implement in clinical practice. Early detection of sarcopenia and SO using simple methods can improve therapy and quality of life for older adults.
EUROPEAN GERIATRIC MEDICINE
(2022)
Article
Geriatrics & Gerontology
Emir Celik, Veysel Suzan, Nilay Sengul Samanci, Aysegul Akkan Suzan, Mehmet Karadag, Serdar Sahin, Muhammed Samil Aslan, Hakan Yavuzer, Nebi Serkan Demirci, Alper Doventas, Fuat Hulusi Demirelli
Summary: This study aimed to determine the possible risk factors for chemotherapy dose-limiting toxicity (DLT) in patients with gastrointestinal (GI) cancer, and found that sarcopenia was the only statistically significant risk factor for chemotherapy DLT. Assessment of sarcopenia evaluated with the current EWGSOP2 diagnostic criteria is useful in predicting chemotherapy DLT development in GI cancer patients.
EUROPEAN GERIATRIC MEDICINE
(2022)
Article
Geriatrics & Gerontology
Maria Claudia Bernardes Spexoto, Paula Camila Ramirez, Roberta de Oliveira Maximo, Andrew Steptoe, Cesar de Oliveira, Tiago da Silva Alexandre
Summary: This study found that grip strength, gait speed, and sarcopenia are important predictors of mortality in older adults, with specific cutoff points providing the best accuracy in identifying mortality risk.
Article
Gastroenterology & Hepatology
J. E. M. Blackwell, P. J. J. Herrod, B. Doleman, H. R. Boyd-Carson, D. Dolan, L. Wheldon, S. R. Brown, A. Banerjea, S. Moug, J. N. Lund, Michael Wong, POMPOMM Collaborative
Summary: This study investigated the relationship between preoperative radiologically defined lean muscle measures and adverse clinical outcomes in patients undergoing surgery for colorectal cancer. The results showed that measures of lean muscle quality and quantity can be quickly and easily taken from routine preoperative imaging, and they can predict important clinical outcomes.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Endocrinology & Metabolism
Jane Skinner, Lee Shepstone, Mary Hickson, Ailsa A. A. Welch
Summary: Alcohol intake is a major modifiable risk factor for many diseases, but it can also damage skeletal muscle health and increase the risk of sarcopenia and frailty. This study aimed to explore the relationship between alcohol consumption and sarcopenic risk in middle-aged and older-aged men and women. The results suggest that higher levels of alcohol consumption could have detrimental effects on muscle mass in this population.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Surgery
Emmanouil Giorgakis, Shirin E. Khorsandi, Amit K. Mathur, Lyle Burdine, Wayel Jassem, Nigel Heaton
Summary: The study findings suggest that using older grafts from donors aged 70 years and above can lead to acceptable outcomes in a highly selected cohort at experienced transplant centers. Advanced age should not be considered an absolute contraindication for utilizing DCD grafts from donors aged 70 years and older.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)