Article
Gastroenterology & Hepatology
Laila Aldars-Garcia, Ruben Gil-Redondo, Nieves Embade, Sabino Riestra, Montserrat Rivero, Ana Gutierrez, Iago Rodriguez-Lago, Luis Fernandez-Salazar, Daniel Ceballos, Jose Manuel Benitez, Mariam Aguas, Iria Baston-Rey, Fernando Bermejo, Maria Jose Casanova, Rufo Lorente, Yolanda Ber, Daniel Ginard, Maria Esteve, Ruth de Francisco, Maria Jose Garcia, Ruben Frances, Ainhoa Rodriguez Pescador, Benito Velayos, Elena Guerra del Rio, Sandra Marin Pedrosa, Alejandro Minguez Sabater, Manuel Barreiro-de Acosta, Alicia Algaba, Cristina Verdejo Gil, Olga Rivas, Vanesa Royo, Montserrat Aceituno, Ana Garre, Montserrat Baldan-Martin, Cristina Ramirez, Ancor Sanz-Garcia, Juan J. Lozano, Julia Sidorova, Oscar Millet, David Bernardo, Javier P. Gisbert, Maria Chaparro
Summary: This study investigates the metabolic differences in different subgroups of newly diagnosed treatment-naive IBD patients. The results indicate alterations in energy and amino acid metabolism in IBD patients, with an increased demand for ketone bodies. The differences in metabolites are more pronounced in Crohn's disease patients compared to ulcerative colitis patients, and in serum compared to urine. Cluster analysis identifies three distinct patient profiles with significant differences in clinical, anthropometric, and metabolomic variables.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pediatrics
Ruth Garcia-Romero, Jose Miguel Martinez de Zabarte Fernandez, Gemma Pujol-Muncunill, Ester Donat-Aliaga, Oscar Segarra-Canton, Inaki Irastorza-Terradillos, Enrique Medina-Benitez, Carlos Jose Ruiz-Hernandez, Marta Carrillo-Palau, Ignacio Ros-Arnal, Alejandro Rodriguez-Martinez, Laura Escartin-Madurga, Carolina Gutierrez-Junquera, Saioa Vicente-Santamaria, Marta Velasco Rodriguez-Belvis, Sonia Fernandez-Fernandez, Jose Ramon Alberto-Alonso, Montserrat Montraveta, Ricardo Torres-Peral, Maria Navalon-Rubio, Victor Manuel Navas-Lopez, Javier Martin de Carpi
Summary: This study assessed the effectiveness and safety of Vedolizumab in children with inflammatory bowel disease, showing that it is a safe and effective option for achieving clinical remission in pediatric patients with primary failure or loss of response to other treatments, especially in UC. High clinical remission rates were observed in pediatric patients refractory to anti-TNF compared to those reported in adults, with few publications on pediatric populations treated with Vedolizumab and with long-term follow-up (52 weeks).
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Bahareh Sophia Khalilipour, Andrew S. Day, Kristin Kenrick, Michael Schultz, Kristina Aluzaite
Summary: This study found substantial diagnostic delays in pediatric patients with IBD and identified significant associations between longer total healthcare diagnostic delays and overall household income and higher self-reported barriers to accessing healthcare.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Montse Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel diseases (IBDs) are chronic and inflammatory conditions affecting the gastrointestinal tract. Despite endoscopy being the gold standard test for assessing IBD, it is invasive and uncomfortable for patients. Therefore, non-invasive biomarkers for IBD diagnosis are urgently needed. This review summarizes proteomics and metabolomics studies in animals and humans, identifying urinary biomarkers for IBD diagnosis. Large-scale multi-omics studies with collaboration between clinicians, researchers, and industry are necessary for the development of sensitive and specific diagnostic biomarkers for personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Ecology
Rachel S. Fitzgerald, Ian R. Sanderson, Marcus J. Claesson
Summary: Paediatric inflammatory bowel disease is a chronic inflammatory disorder of the digestive tract, with increasing global incidence. Genetics, environment, and microbiota are believed to contribute to the development of the disease. Studies have found significant differences in the microbiome of paediatric IBD patients compared to healthy children, with changes in response to treatments and disease severity. Further research into biome differences in paediatric IBD patients may enhance our understanding of the disease's etiology.
Review
Gastroenterology & Hepatology
Laura Arp, Sabine Jansson, Vibeke Wewer, Johan Burisch
Summary: The prevalence of psychiatric comorbidities is high in patients with inflammatory bowel diseases (IBD) and higher than in the general population. Addressing mental health problems in these patients can improve treatment adherence, disease course, and reduce morbidity and mortality.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Multidisciplinary Sciences
Ryan W. Gan, Diana Sun, Amanda R. Tatro, Shirley Cohen-Mekelburg, Wyndy L. Wiitala, Ji Zhu, Akbar K. Waljee
Summary: This study replicated a machine-learning model's ability to predict acute exacerbations of inflammatory bowel disease (IBD) in a nationally representative cohort, with the random forest model outperforming the logistic regression model.
Review
Nutrition & Dietetics
Srishti Saha, Neha Patel
Summary: Inflammatory bowel disease (IBD) is a chronic disorder caused by enteric inflammation in a genetically susceptible host. Diet is widely accepted as an important factor in the pathogenesis of IBD, and various dietary components have been studied for their roles in causing enteric inflammation. Different diets, such as exclusive enteral nutrition, specific carbohydrate diet, and low FODMAPs diet, have also been explored for their effects on IBD patients. This review summarizes the current evidence on the relationship between dietary components and IBD, and provides guidance for dietary modifications in managing IBD.
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Claire Dupont-Lucas, Ariane Leroyer, Delphine Ley, Claire Spyckerelle, Valerie Bertrand, Dominique Turck, Guillaume Savoye, Vincent Maunoury, Nathalie Guillon, Mathurin Fumery, Helene Sarter, Corinne Gower-Rousseau
Summary: This study demonstrates that patients with paediatric-onset inflammatory bowel disease have an increased risk of developing cancer and mortality in adulthood. Colorectal cancer poses the highest risk, which is associated with smoking, exposure to anti-tumour necrosis factor, and combination therapy. Additionally, extraintestinal manifestations are associated with mortality.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Ohad Atia, Sasha Harel, Natan Ledderman, Shira Greenfeld, Revital Kariv, Iris Dotan, Ran Balicer, Barbara Silverman, Eran Matz, Zohar Levi, Matti Waterman, Iris Fried, Jacob M. Rowe, Dan Turner
Summary: Pediatric onset inflammatory bowel disease (PIBD) patients have a higher risk of developing cancer compared to non-inflammatory bowel disease (IBD) children, but the absolute risk is very low, and no significant differences in risk were found among different treatment methods in our data.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Nutrition & Dietetics
Arno R. Bourgonje, Laura A. Bolte, Lianne L. C. Vranckx, Lieke M. Spekhorst, Ranko Gacesa, Shixian Hu, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Janneke N. Samsom, Gerard Dijkstra, Rinse K. Weersma, Marjo J. E. Campmans-Kuijpers
Summary: This study aimed to investigate the association between dietary patterns and circulating inflammatory proteins in patients with inflammatory bowel disease (IBD). The results showed that a high-sugar diet was inversely associated with fibroblast growth factor-19 (FGF-19), while a Mediterranean-style diet was associated with higher FGF-19 levels. A diet characterized by high alcohol and coffee intake was positively associated with CCL11 levels and lower levels of IL-12B.
Review
Gastroenterology & Hepatology
Fabio Salvatore Macaluso, Giuseppina Liguori, Massimo Galli
Summary: Vaccination is crucial in managing patients with inflammatory bowel disease (IBD), yet vaccination rates are low due to lack of awareness among healthcare providers and patients. Current evidence-based recommendations for vaccines and prevention of infectious diseases in IBD patients should be widely promoted and implemented.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Infectious Diseases
Puo-Hsien Le, Cheng-Tang Chiu, Pai-Jui Yeh, Yu-Bin Pan, Cheng-Hsun Chiu
Summary: This study retrospectively evaluated the role of Clostridium innocuum (CI) infection in patients with inflammatory bowel disease (IBD). The results showed that CI infection may lead to poorer clinical remission in ulcerative colitis, which should be considered in the treatment approach.
JOURNAL OF INFECTION
(2022)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Article
Pediatrics
Urszula Daniluk, Jaroslaw Daniluk, Katarzyna Guzinska-Ustymowicz, Anna Pryczynicz, Dariusz Lebensztejn
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2020)
Article
Biochemistry & Molecular Biology
Aleksandra Filimoniuk, Agnieszka Blachnio-Zabielska, Monika Imierska, Dariusz Marek Lebensztejn, Urszula Daniluk
Review
Gastroenterology & Hepatology
Katarzyna Zdanowicz, Magdalena Kucharska, Joanna Reszec, Dariusz Marek Lebensztejn, Urszula Daniluk
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Medicine, General & Internal
Katarzyna Zdanowicz, Magdalena Kucharska, Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn, Urszula Daniluk
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Piotr Deptula, Lukasz Suprewicz, Tamara Daniluk, Andrzej Namiot, Sylwia Joanna Chmielewska, Urszula Daniluk, Dariusz Lebensztejn, Robert Bucki
Summary: This study focuses on the molecular mechanisms related to Helicobacter pylori infection and gastric cancer development. It suggests that the nanomechanical properties of infected tissues could serve as markers of H. pylori presence and the mechanical response of gastric cells to this infection may play a role in promoting cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Jaroslaw Daniluk, Urszula Daniluk, Pawel Rogalski, Agnieszka Swidnicka-Siergiejko, Justyna Wasielica-Berger, Rafal Jacek Kucharski, Stefania Antonowicz, Joanna Reszec, Joanna Maria Lotowska, Piotr Zabielski, Agnieszka Blachnio-Zabielska, Andrzej Dabrowski
Summary: The study found that cigarette smoking promotes the development of chronic pancreatitis in mice exposed to repeated episodes of acute pancreatitis, possibly due to increased expression of K-Ras and NF-Kappa B proteins.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jaroslaw Daniluk, Urszula Daniluk, Pawel Rogalski, Andrzej Dabrowski, Agnieszka Swidnicka-Siergiejko
Summary: Pancreatic ductal adenocarcinoma is a deadly neoplasm with poor prognosis, and the human microbiome may play a role in its pathogenesis. This review summarizes the current understanding of how the microbiome influences pancreatic cancer development and progression, discusses its potential as a marker for diagnosis, progression, and survival, and explores the possibility of modifying the microbiome to improve treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Urszula Daniluk, Kamila Kwiatek-Sredzinska, Piotr Jakimiec, Jaroslaw Daniluk, Aleksandra Czajkowska, Dariusz Marek Lebensztejn
Summary: The study revealed that a significant proportion of children with IBD have liver pathology, with the majority of cases being detected after the diagnosis of IBD. Patients with a specified diagnosis of liver pathology were typically younger and had higher ALT activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Aleksandra Czajkowska, Katarzyna Guzinska-Ustymowicz, Anna Pryczynicz, Dariusz Lebensztejn, Urszula Daniluk
Summary: This study aimed to investigate the relationship between MMP-9 and TIMP-1 and UC phenotypes, disease activity index, and inflammatory markers. The results showed that children with UC had significantly higher levels of these markers in their serum and feces compared to the control group. Additionally, serum MMP-9 correlated with the severity of the disease and other markers, while serum TIMP-1 correlated with disease activity, inflammatory markers, and erythrocyte sedimentation rate. Serum and fecal levels of MMP-9 and TIMP-1 can be useful in distinguishing UC patients and evaluating disease phenotypes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Zdanowicz, Jaroslaw Daniluk, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: The incidence of gallstone disease is increasing, with complex pathogenesis influenced by both genetic and environmental factors. Research on cholelithiasis in children highlights the importance of understanding the disease course and predisposing factors for faster and appropriate diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Katarzyna Zdanowicz, Anna Bobrus-Chcociej, Karolina Pogodzinska, Agnieszka Blachnio-Zabielska, Beata Zelazowska-Rutkowska, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: This study found that there are differences in the concentrations of serum sphingolipids in pediatric patients with cholelithiasis, suggesting that they may serve as potential biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Urszula Daniluk, Paulina Krawiec, Elzbieta Pac-Kozuchowska, Lukasz Dembinski, Jan Stanislaw Bukowski, Aleksandra Banaszkiewicz, Anna Wozniuk-Kazmierczak, Elzbieta Czkwianianc, Jan Brylak, Jaroslaw Walkowiak, Agnieszka Borys-Iwanicka, Anna Kofla-Dlubacz, Tomasz Pytrus, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn
Summary: The coexistence of inflammatory bowel disease (IBD) with pancreatic pathology is rare in children. A retrospective analysis of data from 1538 children diagnosed with IBD in 2014-2021 found that 11.4% of them had pancreatic involvement (PI), with acute pancreatitis (AP) diagnosed in 43.8% and asymptomatic hyperlipasemia (HL) or hyperamylasemia (HA) observed in 50.0%. Routine monitoring of pancreatic enzymes should be performed in patients with IBD, especially after the initiation of azathioprine (AZA) treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Magdalena Kucharska, Katarzyna Zdanowicz, Tamara Daniluk, Robert Bucki, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: This study assessed antibiotic resistance of Helicobacter pylori in previously untreated children in northeast Poland and found a high proportion of strains resistant to at least 1 antibiotic. These results may aid in the selection of appropriate antibiotics for the treatment of Helicobacter pylori infection in our region.
MEDICAL SCIENCE MONITOR
(2023)
Article
Pediatrics
Joanna Ryzko, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: Extraintestinal manifestations (EIMs) are common in patients with inflammatory bowel disease (IBD), with myocarditis being one rare manifestation. We present a case of CD patient with hip joint inflammation and erythema nodosum, along with myopericarditis.
Review
Medicine, General & Internal
Piotr Jakimiec, Katarzyna Zdanowicz, Kamila Kwiatek-Sredzinska, Aleksandra Filimoniuk, Dariusz Lebensztejn, Urszula Daniluk
Summary: This study conducted a systematic review of the literature on pancreatic disorders associated with IBD in children, finding that acute pancreatitis is the most common pancreatic disease in pediatric IBD, with manifestations ranging from asymptomatic increase in pancreatic enzyme activity to severe pancreatitis. The involvement of the pancreas can be closely related to the activity of IBD, and it is recommended to include pancreatic enzyme level measurement in the workup of IBD.
MEDICINA-LITHUANIA
(2021)
