Article
Anatomy & Morphology
Alexandre Veronez, Leticia Albertini Pires, Andrea Aparecida de Aro, Maria Esmeria Corezola do Amaral, Marcelo Augusto Marretto Esquisatto
Summary: The study found that physical exercise in water has a positive effect on the structural organization and chemical composition of fibrocartilage in the tendons of diabetic rats, helping to preserve tendon structure.
Article
Cell Biology
Maria Pilar Solis-Hernandez, Carla Martin, Beatriz Garcia, Natalia Perez-Lopez, Yolanda Garcia-Mesa, Sara Gonzalez-Fernandez, Olivia Garcia-Suarez, Jesus Merayo, Ivan Fernandez-Vega, Luis M. Quiros
Summary: The study found that SLRPs exhibit different transcription and protein expression changes in CCs, which are related to patient survival data. There are distinct patterns of SLRP alterations in right- and left-sided colon tumors, with more deregulations observed in LSCCs. The research suggests that SLRPs may impact cell proliferation and serve as new differential markers for RS and LSCCs.
Review
Biochemistry & Molecular Biology
Shingo Saio, Kanna Konishi, Hirofumi Hohjoh, Yuki Tamura, Teruaki Masutani, Arunasiri Iddamalgoda, Masamitsu Ichihashi, Hiroshi Hasegawa, Ken-ichi Mizutani
Summary: Endothelial cells acquire different phenotypes to establish functional vascular networks, with Vascular Endothelial Growth Factor (VEGF) playing a key role in regulating vascular development. The spatiotemporal localization of angiogenic factors and the extracellular matrix are crucial for proper regulation of angiogenesis. Close interactions between the vascular and neural systems involve shared molecular mechanisms to coordinate developmental and regenerative processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita-Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada, Nobuyuki Udagawa, Johji Kato, Kazuo Kitamura
Summary: This study found that osteoprotegerin protects against aortic rupture and dissection in Ang II-induced hypertension by inhibiting receptor activator of nuclear factor-kappa B ligand activity and periostin expression.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Mari E. Strand, Maarten Vanhaverbeke, Michiel T. H. M. Henkens, Maurits A. Sikking, Karoline B. Rypdal, Bjorn Braathen, Vibeke M. Almaas, Theis Tonnessen, Geir Christensen, Stephane Heymans, Ida G. Lunde
Summary: Circulating biomarkers reflecting cardiac inflammation are needed to improve the diagnostics and guide the treatment of heart failure patients. The shedding of syndecan-4 from cardiac myocytes and fibroblasts was attenuated by immunomodulatory therapy. However, the levels of syndecan-4 did not reflect cardiac inflammatory status in patients with heart disease.
Article
Medicine, General & Internal
Tokuko Hosoya, Goshi Oda, Tsuyoshi Nakagawa, Iichiroh Onishi, Tadashi Hosoya, Megumi Ishiguro, Toshiaki Ishikawa, Hiroyuki Uetake
Summary: The study found that the levels of DCN in plasma varied at different pathological stages in breast cancer patients, suggesting it could be a biomarker for advanced-stage patients. The results indicate that DCN plays an important regulatory role in the development of breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Andrea Reszegi, Peter Tatrai, Eszter Regos, Ilona Kovalszky, Kornelia Baghy
Summary: Syndecan-1 is a protein that regulates cell activities and plays a crucial role in liver diseases and hepatocellular carcinoma. It is involved in various physiological and pathological processes, including cell proliferation, inflammation, and matrix remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
Lorand Vancza, Anna Horvath, Lee Seungyeon, Andras Rokusz, Katalin Dezso, Andrea Reszegi, Gabor Petovari, Martin Goette, Ilona Kovalszky, Kornelia Baghy
Summary: This study explores the role of SPOCK1 in ovarian cancer. It is found that SPOCK1 is associated with poor prognosis and its overexpression stimulates cell proliferation and migration. SPOCK1 is also highly expressed in the blood and tissues of ovarian cancer patients. These findings suggest that SPOCK1 could be a potential therapeutic target and biomarker for ovarian cancer.
Article
Cell Biology
Nicola Chiarelli, Nicoletta Zoppi, Marina Venturini, Daniele Capitanio, Cecilia Gelfi, Marco Ritelli, Marina Colombi
Summary: hEDS is the most common type of EDS characterized by joint hypermobility, chronic pain, and mild skin involvement. The disease mechanism may involve dysfunction of matrix metalloproteinases (MMPs) affecting ECM, offering potential therapeutic targets for improving patients' quality of life.
Article
Neurosciences
Sonam Dolma, Hemant Kumar
Summary: The secondary pathogenesis following primary mechanical damage to the spinal cord is the main obstacle to currently available therapies, with neutrophils and extracellular matrix components inducing scar formation through inflammation, necrosis, and apoptosis, inhibiting axonal regeneration and plasticity.Neutrophils and ECM components are closely associated in pathological conditions, emphasizing the need to identify promising targets by studying their interaction during the acute and chronic phases of spinal cord injury.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Ana A. Jones, Elvira Diamantopoulou, Sarah Baxendale, Tanya T. Whitfield
Summary: Epithelial morphogenesis of the zebrafish inner ear depends on the production and localization of glycosaminoglycans, particularly hyaluronan and proteoglycans, which play critical roles in epithelial projection outgrowth and otolith development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tania Fontanil, Yamina Mohamedi, Jorge Espina-Casado, Alvaro J. Obaya, Teresa Cobo, Santiago Cal
Summary: The hyalectan family, including aggrecan, versican, brevican, and neurocan, plays essential roles in biological processes such as skeletal development and maintenance of the vascular and central nervous system. The ADAMTS family of metalloproteases further affects the extracellular matrix's structure and function through interactions with other matrix components or catalytic activity, targeting hyalectans as preferred substrates for bioactive fragment generation and specific functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Evelin E. Rejman, Rosann Kehoe, John R. Barta
Summary: The complete mitochondrial genome of Eimeria leuckarti, a distinct coccidium species that infects horses, was obtained. Despite its unique appearance, the mitochondrial genome structure and gene contents of E. leuckarti are comparable to other Eimeria species. Phylogenetic analysis showed close affinities between the mt genome of E. leuckarti and other related coccidia species.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Review
Oncology
Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, Liliana Schaefer
Summary: Decorin and biglycan play critical roles in tumor biology by influencing key processes that affect tumor growth and progression. Despite their structural homology, these proteoglycans interact with different cell surface receptors, modulating distinct signaling pathways that ultimately impact cancer development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Orthopedics
B. Han, Q. Li, C. Wang, P. Chandrasekaran, Y. Zhou, L. Qin, X. S. Liu, M. Enomoto-Iwamoto, D. Kong, R. V. Iozzo, D. E. Birk, L. Han
Summary: In post-traumatic osteoarthritis (PTOA), decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Gastroenterology & Hepatology
Kerstin Schneeberger, Natalia Sanchez-Romero, Shicheng Ye, Frank G. van Steenbeek, Loes A. Oosterhoff, Iris Pla Palacin, Chen Chen, Monique E. van Wolferen, Gilles van Tienderen, Ruby Lieshout, Haaike Colemonts-Vroninks, Imre Schene, Ruurdtje Hoekstra, Monique M. A. Verstegen, Luc J. W. van der Laan, Louis C. Penning, Sabine A. Fuchs, Hans Clevers, Joery De Kock, Pedro M. Baptista, Bart Spee
Article
Agriculture, Dairy & Animal Science
Maria Lozano-Jaramillo, Hans Komen, Yvonne C. J. Wientjes, Han A. Mulder, John W. M. Bastiaansen
JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Cell Biology
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Monique E. van Wolferen, Chen Chen, Sathidpak Nantasanti Assawarachan, Kerstin Schneeberger, Anne Kummeling, Giora van Straten, Ies C. Akkerdaas, Christel R. Vinke, Frank G. van Steenbeek, Leonie W. L. van Bruggen, Jeannette Wolfswinkel, Guy C. M. Grinwis, Sabine A. Fuchs, Helmuth Gehart, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Article
Chemistry, Multidisciplinary
Shicheng Ye, Jochem W. B. Boeter, Marko Mihajlovic, Frank G. van Steenbeek, Monique E. van Wolferen, Loes A. Oosterhoff, Ary Marsee, Massimiliano Caiazzo, Luc J. W. van der Laan, Louis C. Penning, Tina Vermonden, Bart Spee, Kerstin Schneeberger
ADVANCED FUNCTIONAL MATERIALS
(2020)
Review
Biotechnology & Applied Microbiology
Iris Ribitsch, Pedro M. Baptista, Anna Lange-Consiglio, Luca Melotti, Marco Patruno, Florien Jenner, Eva Schnabl-Feichter, Luke C. Dutton, David J. Connolly, Frank G. van Steenbeek, Jayesh Dudhia, Louis C. Penning
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Genetics & Heredity
P. J. J. Mandigers, F. G. Van Steenbeek, W. Bergmann, M. Vos-Loohuis, P. A. Leegwater
Summary: A juvenile form of paroxysmal dyskinesia was identified in the Markiesje dog breed, with a frameshift mutation in the SOD1 gene being the underlying cause. The mutation showed full penetrance in affected dogs but was not found in other analyzed dogs of the breed. This genetic defect leads to a distinct juvenile neurologic disease, different from the related diseases seen in humans and other dog breeds.
Article
Multidisciplinary Sciences
Francesca Genova, Simona Nonnis, Elisa Maffioli, Gabriella Tedeschi, Maria Giuseppina Strillacci, Michela Carisetti, Giuseppe Sironi, Francesca Anna Cupaioli, Noemi Di Nanni, Alessandra Mezzelani, Ettore Mosca, Christopher R. Helps, Peter A. J. Leegwater, Laetitia Dorso, Maria Longeri, Reuben M. Buckley, Danielle Aberdein, Paulo C. Alves, Asa Ohlsson Andersson, Gregory S. Barsh, Rebecca R. Bellone, Tomas F. Bergstrom, Adam R. Boyko, Jeffrey A. Brockman, Margret L. Casal, Marta G. Castelhano, Ottmar Distl, Nicholas H. Dodman, N. Matthew Ellinwood, Jonathan E. Fogle, Oliver P. Forman, Dorian J. Garrick, Edward Ginns, Bianca Haase, Jens Haggstrom, Robert J. Harvey, Daisuke Hasegawa, Isabel Hernandez, Marjo K. Hytonen, Maria Kaukonen, Christopher B. Kaelin, Tomoki Kosho, Emilie Leclerc, Teri L. Lear, Tosso Leeb, Ronald H. L. Li, Hannes Lohi, Mark A. Magnuson, Richard Malik, Shrinivasrao P. Mane, John S. Munday, William J. Murphy, Niels C. Pedersen, Simon M. Peterson-Jones, Max F. Rothschild, Clare Rusbridge, Beth Shapiro, Joshua A. Stern, William F. Swanson, Karen A. Terio, Rory J. Todhunter, Wesley C. Warren, Elizabeth A. Wilcox, Julia H. Wildschutte, Yoshihiko Yu, Leslie A. Lyons
Summary: The study utilized multi-omics analyses to explore unknown pathogenetic processes in Abyssinian cats with amyloidosis, revealing genomic variants, protein expression differences, and differential miRNA expression. The familial amyloid renal form is not a simple monogenic trait and amyloid deposition is triggered by a mix of proteins coded by wild-type genes. This form of amyloidosis in Abyssinian cats can be biochemically classified as AA amyloidosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
J. Pei, M. Schuldt, E. Nagyova, Z. Gu, S. el Bouhaddani, L. Yiangou, M. Jansen, J. J. A. Calis, L. M. Dorsch, C. Snijders Blok, N. A. M. van den Dungen, N. Lansu, B. J. Boukens, I. R. Efimov, M. Michels, M. C. Verhaar, R. de Weger, A. Vink, F. G. van Steenbeek, A. F. Baas, R. P. Davis, H. W. Uh, D. W. D. Kuster, C. Cheng, M. Mokry, J. van der Velden, F. W. Asselbergs, M. Harakalova
Summary: Through integrating histone acetylome, transcriptome, and proteome profiles, we identified major effector genes and protein networks driving pathological changes in HCM with mutated MYBPC3. Our work identifies 38 highly affected protein-coding genes as potential plasma HCM biomarkers and 9 TFs as potential upstream regulators of these pathomechanisms that may serve as possible therapeutic targets.
CLINICAL EPIGENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Christopher A. Jenkins, Ellen C. Schofield, Cathryn S. Mellersh, Luisa De Risio, Sally L. Ricketts
Summary: Genotype imputation using a reference panel combining high-density array data with publicly available whole genome sequence consortium variant data is shown to be an effective and accurate method to increase the density of lower-density array datasets in dogs. The study demonstrates high accuracy in imputation, utilizing reference panels consisting of breed-specific array data and multi-breed variant data. The findings provide evidence and support for the efficacy of this approach in canine genetics.
Review
Agriculture, Dairy & Animal Science
Karen R. Gaar-Humphreys, Talitha C. F. Spanjersberg, Giorgia Santarelli, Guy C. M. Grinwis, Viktor Szatmari, Bernard A. J. Roelen, Aryan Vink, J. Peter van Tintelen, Folkert W. Asselbergs, Hille Fieten, Magdalena Harakalova, Frank G. van Steenbeek
Summary: Heart disease is a major cause of death in both humans and dogs, with genetic cardiomyopathies like dilated cardiomyopathy (DCM) accounting for a portion of these cases. DCM in both species is characterized by ventricular enlargement and dysfunction, leading to heart failure and arrhythmias. Despite similarities in disease progression and subtypes, the genetic background of DCM has been more extensively studied in humans than in dogs. Different dog breeds have been found to develop distinct DCM phenotypes, providing a unique opportunity for modeling. Understanding DCM in dogs can improve breeding selection and overall care for both human and canine DCM patients. This review examines the feasibility of using dogs as a naturally occurring bidirectional disease model for DCM and discusses the potential use of engineered stem cells for disease modeling and treatment.
Article
Biochemistry & Molecular Biology
Manon C. Bouwmeester, Yu Tao, Susana Proenca, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer, Bart Spee
Summary: In vitro toxicity testing using hepatocyte-like intrahepatic cholangiocyte organoids (HL-ICOs) allows for the evaluation of drug metabolism gene expression and activity, providing insights into the extent of drug-induced hepatotoxicity.
Article
Veterinary Sciences
Karin Sanders, Hans S. Kooistra, Marieke van den Heuvel, Michal Mokry, Guy C. M. Grinwis, Noortje A. M. van den Dungen, Frank G. van Steenbeek, Sara Galac
Summary: Cushing's syndrome (CS) is more common in dogs and is caused by cortisol-secreting adrenocortical tumours (csACTs) in a significant percentage of cases. By performing RNA sequencing on csACTs and normal adrenal cortices (NACs) of dogs, differentially expressed genes were identified that can improve prognosis and serve as treatment targets. Cytochrome P450 26B1 (CYP26B1) was found to be significantly associated with survival in both canine and human csACTs. Further research could explore the potential use of CYP26B1 inhibitors for inhibiting csACT growth in dogs and humans.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Maud A. J. de Kinderen, Johann Soelkner, Gabor Meszaros, Setegn W. Alemu, Wondmeneh Esatu, John W. M. Bastiaansen, Hans Komen, Tadelle Dessie
Summary: Ethiopia, a developing nation, could benefit greatly from improving smallholder poultry farming. G*E analyses were conducted to determine the best chicken strain for different Ethiopian environments in terms of predicted body weight (BW). The study found significant G*E effects, with the Sasso strain performing best in terms of predicted BW.
Article
Biology
Xiaoyan Wu, Elise R. den Boer, Manon Vos-Loohuis, Frank G. van Steenbeek, Glen R. Monroe, Isaac J. Nijman, Peter. A. J. Leegwater, Hille Fieten