Article
Biochemistry & Molecular Biology
Chengting Luo, Changmei Yang, Xueying Wang, Yuling Chen, Xiaohui Liu, Haiteng Deng
Summary: Research showed that nicotinamide supplementation can reduce fat mass in obese mice, improve glucose tolerance, and enhance mitochondrial function in adipose tissue. Nicotinamide activates NAMPT and increases cellular NAD(+) levels to reprogram cellular metabolism for better adipose tissue function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Elizabeth A. Novak, Erin C. Crawford, Heather L. Mentrup, Brian D. Griffith, David M. Fletcher, Meredith R. Flanagan, Corinne Schneider, Brian Firek, Matthew B. Rogers, Michael J. Morowitz, Jon D. Piganelli, Qian Wang, Kevin P. Mollen
Summary: This study demonstrates that the downregulation of PGC1 alpha and the decrease in NAD+ levels are associated with the pathogenesis of inflammatory bowel disease. Treatment with an NAD+ precursor can alleviate colitis symptoms and restore mitochondrial function by increasing the activity of PGC1 alpha. These findings highlight the importance of PGC1 alpha in intestinal epithelial health and suggest a potential therapeutic approach for IBD patients using nicotinamide riboside.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Wenli Li, Yujia Zhou, Nengzhi Pang, Qianrong Hu, Qiuyan Li, Yan Sun, Yijie Ding, Yingying Gu, Ying Xiao, Mengqi Gao, Sixi Ma, Jie Pan, Evandro Fei Fang, Zhenfeng Zhang, Lili Yang
Summary: This study investigated the effects of nicotinamide riboside (NR) on ethanol-induced intestinal barrier dysfunction and the underlying mechanisms using a mouse model and Caco-2 cells. The results showed that NR supplementation can alleviate ethanol-induced intestinal barrier damage through activation of SirT1 and maintenance of mitochondrial function.
Article
Neurosciences
Chen Shen, Cong Chen, Tong Wang, Tong-Yao Gao, Min Zeng, Yun-Bi Lu, Wei-Ping Zhang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme in the salvaging synthesis pathway of nicotinamide adenine dinucleotide (NAD). Depletion of NAMPT can lead to cognitive deficiency in hippocampus neurons and increase the risk of neurodegeneration due to mitochondrial dysfunction.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biology
Knut H. Lauritzen, Maria Belland Olsen, Mohammed Shakil Ahmed, Kuan Yang, Johanne Egge Rinholm, Linda H. Bergersen, Qin Ying Esbensen, Lars Jansen Sverkeli, Mathias Ziegler, Havard Attramadal, Bente Halvorsen, Pal Aukrust, Arne Yndestad
Summary: High levels of mtDNA damage lead to reduced NAD(+) levels, affecting the activity of SIRT3, while high dosages of nicotinamide riboside also inhibit sirtuin activity, resulting in irregular cardiac mitochondrial morphology. Therefore, caution should be exercised when using high doses of NR in cases where cardiomyopathic symptoms are caused by mitochondrial dysfunction and mtDNA instability.
Article
Plant Sciences
Zihan Zheng, Yushan Xian, Zhen Jin, Feng Yao, YiZhen Liu, Ying Deng, Bo Wang, Danli Chen, Jianjun Yang, Lingxuan Ren, Rong Lin
Summary: Rhaponticum carthamoides exerts its protective effects on myocardial injury by regulating energy metabolism and oxidative stress through the SIRT6/Nrf2 signaling pathway.
Article
Biochemistry & Molecular Biology
Min Li, Lydie Plecita-Hlavata, Evgenia Dobrinskikh, B. Alexandre McKeon, Aneta Gandjeva, Suzette Riddle, Aya Laux, Ram Raj Prasad, Sushil Kumar, Rubin M. Tuder, Hui Zhang, Cheng-Jun Hu, Kurt R. Stenmark
Summary: The study found that abnormal SIRT3 activity is related to mitochondrial dysfunction in adventitial fibroblasts from patients with pulmonary hypertension. Restoration of SIRT3 activity can reduce mitochondrial protein acetylation and restore mitochondrial function.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shima Mehrvar, Soudeh Mostaghimi, Farnaz H. Foomani, Betsy Abroe, Janis T. Eells, Sandeep Gopalakrishnan, Mahsa Ranji
Summary: The study quantitatively evaluated the effect of far-red light exposure on mitochondrial bioenergetics of diabetic wounds and found that far-red light exposure improved mitochondrial function and accelerated wound healing, possibly through increasing mitochondrial RR and reducing oxidative stress.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Yongwoo Jang, Taegyu Park, Eunyoung Kim, Jong Woo Park, Dong Yeop Lee, Seon Jeong Kim
Summary: By utilizing the cellular redox system, a CNT yarn supercapacitor with maximum area capacitance was developed and demonstrated excellent performance under physiological conditions. Implanted NAD/BQ/CNT yarn electrodes in a rat's abdominal cavity showed stable in vivo electrical performance of a supercapacitor. These findings suggest a promising platform for implantable energy storage devices using redox biomolecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemical Research Methods
Amani A. Gillette, Rebecca A. DeStefanis, Stephanie L. Pritzl, Dustin A. Deming, Melissa C. Skala
Summary: This study investigates the effects of Bcl-2 family protein inhibitors on cellular metabolism and finds that the optical redox ratio (ORR) is sensitive to changes in mitochondrial function and cell senescence, which can occur independently of cell viability. The metabolic changes caused by ABT-263 treatment can be mitigated by combination with mTORC1/2 inhibitors.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Review
Nutrition & Dietetics
Andrea Benzi, Alessia Grozio, Sonia Spinelli, Laura Sturla, Andreas H. Guse, Antonio De Flora, Elena Zocchi, Joerg Heeren, Santina Bruzzone
Summary: Nicotinamide adenine dinucleotide (NAD(+)) plays a critical role in energy metabolism regulation as both a coenzyme and substrate for various enzymes. CD38, as an enzyme synthesizing Ca2+-mobilizing second messenger and a major NAD(+)-consumer, can impact NAD(+) levels. This review explores recent studies on the modulation of CD38 expression and activity, and the resulting changes in NAD(P)(H) levels in adipose tissue.
Article
Biochemistry & Molecular Biology
Cuiting Liao, Li Zhang, Rong Jiang, Juanjuan Xu, Jiarui Tang, Kai Hu, Shifang Jiang, Longhui Li, Yongqiang Yang, Jiayi Huang, Li Tang, Longjiang Li
Summary: The expression of NADK is positively correlated with APAP-induced acute liver injury, and inhibition of NADK can alleviate liver injury by increasing hepatic NAD(+) level and improving antioxidant capacity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Mariajose Metcalfe, Brian T. David, Brett C. Langley, Caitlin E. Hill
Summary: Spinal cord injury leads to tissue damage and functional deficits. Administering NR can increase NAD+ levels in the injured spinal cord, protect tissue, and improve motor function.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Yumeng Zhu, Ping Xu, Xuan Huang, Wen Shuai, Li Liu, Shuai Zhang, Rui Zhao, Xiuying Hu, Guan Wang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) plays a significant role in mammals by synthesizing nicotinamide mononucleotide (NMN) for metabolic homeostasis and cell survival, serving as a key protein in the host's defense mechanism. Neurodegenerative diseases pose a serious threat to human health, but effective drugs are limited. NAMPT has active biological functions in neurogenesis, making it a powerful therapeutic target for neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Qin Song, Xiaofeng Zhou, Kexin Xu, Sishi Liu, Xinqiang Zhu, Jun Yang
Summary: Nicotinamide mononucleotide (NMN) is a precursor for NAD+ biosynthesis, and supplementation has shown to increase NAD+ concentration and alleviate aging-related disorders. While most studies have been conducted in cell or animal models, several human clinical trials are currently evaluating the safety and physiological effects of NMN supplementation.
ADVANCES IN NUTRITION
(2023)
Letter
Cardiac & Cardiovascular Systems
Ao Chen, Yingmin Chen
CANADIAN JOURNAL OF CARDIOLOGY
(2015)
Article
Medicine, General & Internal
Yuan-Yuan Cao, Zhang-Wei Chen, Jian-Guo Jia, Ao Chen, You Zhou, Yong Ye, Yan-Hua Gao, Yan Xia, Shu-Fu Chang, Jian-Ying Ma, Ju-Ying Qian, Jun-Bo Ge
CHINESE MEDICAL JOURNAL
(2016)
Article
Cardiac & Cardiovascular Systems
Yunhe Zhang, Ao Chen, Lei Song, Min Li, Yingmin Chen, Ben He
INTERNATIONAL HEART JOURNAL
(2016)
Article
Cardiac & Cardiovascular Systems
Yan Xia, Zhangwei Chen, Ao Chen, Mingqiang Fu, Zhen Dong, Kai Hu, Xiangdong Yang, Yunzeng Zou, Aijun Sun, Juying Qian, Junbo Ge
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Yan Xia, Zhangwei Chen, Ao Chen, Danbo Lu, Jianguo Jia, Yunzeng Zou, Juying Qian, Junbo Ge
Article
Biochemistry & Molecular Biology
Ao Chen, Zhangwei Chen, Yan Xia, Danbo Lu, Xiangdong Yang, Aijun Sun, Yunzeng Zou, Juying Qian, Junbo Ge
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Physiology
Ao Chen, Zhangwei Chen, Yan Xia, Danbo Lu, Jianguo Jia, Kai Hu, Aijun Sun, Yunzeng Zou, Juying Qian, Junbo Ge
FRONTIERS IN PHYSIOLOGY
(2018)
Review
Cell & Tissue Engineering
Mengkang Fan, Yin Huang, Zhangwei Chen, Yan Xia, Ao Chen, Danbo Lu, Yuan Wu, Ning Zhang, Juying Qian, Junbo Ge
STEM CELL RESEARCH & THERAPY
(2019)
Correction
Cell & Tissue Engineering
Mengkang Fan, Yin Huang, Zhangwei Chen, Yan Xia, Ao Chen, Danbo Lu, Yuan Wu, Ning Zhang, Juying Qian
STEM CELL RESEARCH & THERAPY
(2019)
Article
Physiology
Danbo Lu, Yan Xia, Zhangwei Chen, Ao Chen, Yuan Wu, Jianguo Jia, Aijun Sun, Yunzeng Zou, Juying Qian, Junbo Ge
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jiaqi Ma, Zhangwei Chen, Yuanji Ma, Yan Xia, Kai Hu, You Zhou, Ao Chen, Juying Qian, Junbo Ge
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Cardiac & Cardiovascular Systems
You Zhou, Zhangwei Chen, Jiaqi Ma, Ao Chen, Danbo Lu, Yuan Wu, Daoyuan Ren, Chi Zhang, Chunfeng Dai, Yaqi Zhang, Juying Qian, Junbo Ge
JOURNAL OF CARDIOLOGY
(2020)
Article
Cell Biology
Ao Chen, Zhangwei Chen, You Zhou, Yuan Wu, Yan Xia, Danbo Lu, Mengkang Fan, Su Li, Jinxiang Chen, Aijun Sun, Yunzeng Zou, Juying Qian, Junbo Ge
Summary: In this study, it was found that the NLRP3 inflammasome plays an important role in CME-induced cardiac injury, and treatment with rosuvastatin (RVS) can improve cardiac function, reduce damage, and lower ROS levels.
CELL DEATH & DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Yunhe Zhang, Ao Chen, Lei Song, Min Li, Zhangyuan Luo, Wenzan Zhang, Yingmin Chen, Ben He
INTERNATIONAL HEART JOURNAL
(2016)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.