Pathophysiology of hypoxic–ischemic encephalopathy: a review of the past and a view on the future

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

(2019) Christian A. Maiwald et al.   BMC Pediatrics

The impact of hypoxic-ischemic brain injury on stem cell mobilization, migration, adhesion, and proliferation

(2018) EricS Peeples et al.   Neural Regeneration Research

Nitric Oxide Synthase Inhibition as a Neuroprotective Strategy Following Hypoxic–Ischemic Encephalopathy: Evidence From Animal Studies

(2018) Laurent M. A. Favié et al.   Frontiers in Neurology

Melatonin Acts in Synergy with Hypothermia to Reduce Oxygen-Glucose Deprivation-Induced Cell Death in Rat Hippocampus Organotypic Slice Cultures

(2018) Silvia Carloni et al.   Neonatology

Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy

(2018) Paolo Montaldo et al.   Neonatology

Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment

(2016) Edibe Pembegül Yıldız et al.   Expert Review of Neurotherapeutics

Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats

(2016) Ying Xu et al.   JOURNAL OF NEUROCHEMISTRY

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial

(2016) Denis Azzopardi et al.   LANCET NEUROLOGY

Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia

(2016) Kevin D. Broad et al.   NEUROBIOLOGY OF DISEASE

Therapeutic hypothermia translates from ancient history in to practice

(2016) Alistair J. Gunn et al.   PEDIATRIC RESEARCH

Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment

(2016) Edibe Pembegül Yıldız et al.   Expert Review of Neurotherapeutics

Effect of maternal exercise on biochemical parameters in rats submitted to neonatal hypoxia-ischemia

(2015) Thiago Beltram Marcelino et al.   BRAIN RESEARCH

Role of mitochondria in apoptotic and necroptotic cell death in the developing brain

(2015) Claire Thornton et al.   CLINICA CHIMICA ACTA

NF-κB Signaling is Involved in the Effects of Intranasally Engrafted Human Neural Stem Cells on Neurofunctional Improvements in Neonatal Rat Hypoxic-Ischemic Encephalopathy

(2015) Gang Ji et al.   CNS Neuroscience & Therapeutics

Neuroprotective agents for neonatal hypoxic–ischemic brain injury

(2015) Qiaofeng Wu et al.   DRUG DISCOVERY TODAY

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Darbepoetin administration to neonates undergoing cooling for encephalopathy: a safety and pharmacokinetic trial

(2015) Mariana C. Baserga et al.   PEDIATRIC RESEARCH

Cooling in a low-resource environment: Lost in translation

(2015) Paolo Montaldo et al.   Seminars in Fetal & Neonatal Medicine

Magnesium Is Not Consistently Neuroprotective for Perinatal Hypoxia-Ischemia in Term-Equivalent Models in Preclinical Studies: A Systematic Review

(2014) Robert Galinsky et al.   DEVELOPMENTAL NEUROSCIENCE

Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study

(2014) H Aly et al.   Journal of Perinatology

The mechanisms and treatment of asphyxial encephalopathy

(2014) Guido Wassink et al.   Frontiers in Neuroscience

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

Magnesium for newborns with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis

(2013) M Tagin et al.   Journal of Perinatology

Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a mouse model of neonatal hypoxic-ischemic brain injury

(2013) Mizuya Shinoyama et al.   Frontiers in Cellular Neuroscience

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Therapeutic Hypothermia for Neonatal Encephalopathy

(2012) Seetha Shankaran   Current Treatment Options in Neurology

A xenon recirculating ventilator for the newborn piglet

(2012) Stuart D. Faulkner et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells

(2012) Holly F. Green et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia

(2011) Stuart Faulkner et al.   ANNALS OF NEUROLOGY

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

Hypothermia and Other Treatment Options for Neonatal Encephalopathy: An Executive Summary of the Eunice Kennedy Shriver NICHD Workshop

(2011) Rosemary D. Higgins et al.   JOURNAL OF PEDIATRICS

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs

(2010) Elavazhagan Chakkarapani et al.   ANNALS OF NEUROLOGY

Epidemiology of neonatal encephalopathy and hypoxic–ischaemic encephalopathy

(2010) Jennifer J. Kurinczuk et al.   EARLY HUMAN DEVELOPMENT

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

(2010) Caoimhín G. Concannon et al.   JOURNAL OF CELL BIOLOGY

Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting in Neonatal Hypoxic–Ischemic Brain Injury

(2010) Marcel M. Daadi et al.   STROKE

Enhancement of Autophagic Flux after Neonatal Cerebral Hypoxia-Ischemia and Its Region-Specific Relationship to Apoptotic Mechanisms

(2009) Vanessa Ginet et al.   AMERICAN JOURNAL OF PATHOLOGY

Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts

(2009) T. Yasuhara et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Increased Umbilical Cord Plasma Interleukin-1  Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

(2009) J. Liu et al.   JOURNAL OF TROPICAL PEDIATRICS

Magnesium Sulfate in Severe Perinatal Asphyxia: A Randomized, Placebo-Controlled Trial

(2009) M. A. Bhat et al.   PEDIATRICS

Human Cord Blood Transplantation in a Neonatal Rat Model of Hypoxic–Ischemic Brain Damage: Functional Outcome Related to Neuroprotection in the Striatum

(2009) Pedro M. Pimentel-Coelho et al.   STEM CELLS AND DEVELOPMENT

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Time Courses of Intrapartum Asphyxia: Neonatal Characteristics and Outcomes

(2008) Prakesh Shah et al.   AMERICAN JOURNAL OF PERINATOLOGY