4.8 Article

Metal-Organic Framework-Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 9, Pages 10503-10514

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b22445

Keywords

metal-organic frameworks; microfluidics; impedance; petfluorooctanesulfonate; sensing; detection

Funding

  1. Laboratory Directed Research and Development Program at the Pacific Northwest National Laboratory (SEED EED)
  2. National Science Foundation (NSF) Career grant [1751759]
  3. U.S. Department of Energy [DE-AC05-76RL01830]
  4. Div Of Chem, Bioeng, Env, & Transp Sys
  5. Directorate For Engineering [1751759] Funding Source: National Science Foundation

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The growing global concerns to public health from human exposure to perfluorooctanesulfonate (PFOS) require rapid, sensitive, in situ detection where current, state-of-the-art techniques are yet to adequately meet sensitivity standards of the real world. This work presents, for the first time, a synergistic approach for the targeted affinity-based capture of PFOS using a porous sorbent probe that enhances detection sensitivity by embedding it on a microfluidic platform. This novel sorbent-containing platform functions as an electrochemical sensor to directly measure PFOS concentration through a proportional change in electrical current (increase in impedance). The extremely high surface area and pore volume of mesoporous metal-organic framework (MOF) Cr-MIL-101 is used as the probe for targeted PFOS capture based on the affinity of the chromium center toward both the fluorine tail groups as well as the sulfonate functionalities as demonstrated by spectroscopic (NMR and XPS) and microscopic (TEM) studies. Answering the need for an ultrasensitive PFOS detection technique, we are embedding the MOF capture probes inside a microfluidic channel, sandwiched between interdigitated microelectrodes (ID mu E). The nanoporous geometry, along with interdigitated microelectrodes, increases the signal-to-noise ratio tremendously. Further, the ability of the capture probes to interact with the PFOS at the molecular level and effectively transduce that response electrochemically has allowed us achieve a significant increase in sensitivity. The PFOS detection limit of 0.5 ng/L is unprecedented for in situ analytical PFOS sensors and comparable to quantification limits achieved using state-of-the-art ex situ techniques.

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