Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 2, Pages 2049-2058Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b17948
Keywords
graphene oxide; graphene fiber; microfluidic spinning; 3D printing; tissue engineering
Funding
- National Natural Science Foundation of China [1161101223, 31600804]
- Joint Fund of China Ministry of Education [6141A020226]
- Key Research and Development Program of Shaanxi [S2018-FY-ZDGY-0229]
- Natural Science Basic Research Plan in the Shaanxi Province of China [2017JQ3035]
- China Postdoctoral Science Foundation [2018T111071, 2016M592799]
- Fundamental Research Funds for the Central Universities [xjj2016081]
- Research Grant Council of Hong Kong SAR [16204815]
- NSFC-RGC Joint Research Scheme [N_HKUST607/17]
- GDAS' Project of Science and Technology Development [2020GDASYL-20200103139]
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Graphene materials have attracted special attention because of their electrical conductivity, mechanical properties, and favorable biocompatibility. Although various methods have been developed for fabricating micro/nano conductive fibrous scaffolds, it is still challenging to fabricate the three-dimensional (3D) graphene fibrous scaffolds. Herein, we developed a new method, termed as microfluidic 3D printing technology (M3DP), to fabricate 3D graphene oxide (GO) microfibrous scaffolds with an adjustable fiber length, fiber diameter, and scaffold structure by integrating the microfluidic spinning technology with a programmable 3D printing system. GO microfibrous scaffolds were then transformed into conductive reduced graphene oxide (rGO) microfibrous scaffolds by hydrothermal reduction. Our results demonstrated that the fabricated 3D fibrous graphene scaffolds exhibited tunable structures, maneuverable mechanical properties, and good electrical conductivity and biocompatibility, as reflected by the adhesion and proliferation of SH-SY5Y cells on the graphene microfibrous scaffolds in an obviously oriented manner. The developed M3DP would be a powerful tool for fabricating 3D graphene microfibrous scaffolds for electroactive tissue regeneration and drug-screening applications.
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