Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Article
Surgery
Akira Ikumi, Anne Gingery, Yoichi Toyoshima, Chunfeng Zhao, Steven L. Moran, Christopher Livia, Tyler Rolland, Timothy Peterson, Michael S. Sabbah, Soulmaz Boroumand, Tiam M. Saffari, Atta Behfar, Alexander Y. Shin, Peter C. Amadio
Summary: The study demonstrated improved functional motor recovery and nerve regeneration profiles in a rat sciatic nerve reverse autograft model with the local administration of purified exosome product. This suggests beneficial effects on nerve regeneration, gene profiles, and motor outcomes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Engineering, Biomedical
Shuai Wei, Qian Hu, Jianxiong Ma, Xiu Dai, Yu Sun, Gonghai Han, Haoye Meng, Wenjing Xu, Lei Zhang, Xinlong Ma, Jiang Peng, Yu Wang
Summary: Compared to conventional artificial nerve guide conduits, acellular nerve grafts derived from natural nerves have natural advantages. In this study, a composite technology based on supercritical carbon dioxide was used to process the peripheral nerve of a large mammal and obtain acellular nerve xenografts. The extracted grafts showed improved cell adhesion and proliferation, reduced inflammatory response, and promoted nerve regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Liangfu Jiang, Xingyu Ouyang, Dupiao Zhang, Gang Wang, Zhe Zhang, Wei Wang, Hede Yan
Summary: This study presents a Gel-Ppy modified nerve conduit with excellent biocompatibility and conductivity, and evaluates its performance in promoting nerve regeneration in vitro and in vivo. The results demonstrate that Gel-Ppy modified nerve conduit can significantly enhance Schwann cell proliferation, contribute to Schwann cell regeneration in vivo, and improve axon diameters and myelin sheath thickness, leading to the amelioration of muscle atrophy, nerve conduction, and motor function recovery. Further investigation indicates that the Gel-Ppy conduit facilitates nerve regeneration by upregulating the Rap1 pathway to induce neurite outgrowth. Therefore, Gel-Ppy modified nerve conduit can provide a favorable microenvironment for nerve regeneration and be popularized as a novel therapeutic strategy for peripheral nerve injury.
Article
Chemistry, Medicinal
Haili Xiao, Chao Wei, Huiying Liu, Zhiqiang Li, Cihua Zheng, Jun Luo
Summary: The natural drug lentinan has been found to regulate autophagy, promoting the clearance of myelin debris and enhancing nerve regeneration. The study demonstrated that lentinan activates the AMPK/mTOR signaling pathway, accelerating autophagic flux and promoting the phagocytosis of myelin debris by Schwann cells. These findings suggest that lentinan may be a cost-effective and natural treatment for peripheral nerve injury.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yao Wang, Zongliang Xiong, Chong Zhou, Qiyuan Zhang, Shuang Liu, Sainan Dong, Xiaowen Jiang, Wenhui Yu
Summary: The study demonstrates that AKBA has a pro-recovery effect on sciatic nerve injury by promoting axon regeneration and improving cellular components of myelin sheath. AKBA regulates the expression of CDC42, Rac1, RhoA, and Rictor, which play important roles in nerve repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Yongke Yang, Chang Rao, Tianlong Yin, Shaokang Wang, Huiyan Shi, Xin Yan, Lili Zhang, Xianggang Meng, Wenlong Gu, Yuzheng Du, Feng Hong
Summary: Peripheral nerve injury (PNI) is a structural event with harmful consequences worldwide. Acupuncture has been shown to be effective in treating PNI-induced neurologic deficits, potentially by activating neurotrophic substances and promoting nerve regeneration and repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Anjali Yadav, Thamil Selvee Ramasamy, Sheng-Che Lin, Szu-Han Chen, Jean Lu, Ya-Hsin Liu, Fu- Lu, Yuan-Yu Hsueh, Shau-Ping Lin, Chia-Ching Wu
Summary: The failure of peripheral nerve regeneration may be attributed to the lack of a permissive environment for nerve repair. The use of autologous platelet-rich plasma (PRP) or its derivative platelet-rich growth factors (PRGF) has been shown to improve peripheral nerve regeneration by modulating macrophage polarization. In this study, PRGF was found to reduce inflammation and promote the shift of macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. This led to improved nerve regeneration in a rat sciatic nerve transection model. The findings suggest that autologous PRGF has the potential to regulate inflammatory microenvironments and promote nerve repair.
Article
Cell Biology
Bo Wang, Chang-Feng Lu, Zhong-Yang Liu, Shuai Han, Pi Wei, Dian-Ying Zhang, Yu-Hui Kou, Bao-Guo Jiang
Summary: A novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in rats, and it effectively facilitated nerve regeneration and restored neurological function, suggesting its potential as a new option for tissue-engineered nerve scaffolds.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Jie Yang, Chia-Chen Hsu, Ting-Ting Cao, Hua Ye, Jing Chen, Yun-Qing Li
Summary: A hyaluronic acid granular hydrogel was found to promote neuronal and astrocyte colony formation and axonal extension in vitro, mimicking an extracellular matrix structure for neural regeneration. Transplantation of the hydrogel nerve guidance conduit successfully repaired a 10-mm long sciatic nerve gap, showing similar regeneration of axons and myelin sheath, as well as recovery of electrophysiological and motor functions. The conduit outperformed bulk hydrogel or silicone tube transplant. These findings suggest that tissue-engineered nerve conduits with hyaluronic acid granular hydrogels effectively promote the morphological and functional recovery of injured peripheral nerves.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Biomedical
Antonio Merolli, Michelle Li, Gregory Voronin, Lauren Bright
Summary: In recent years, there has been an increase in studies on nerve transection injuries using the sciatic nerve gap-injury model in rabbits. This paper aims to define in detail the requirements for testing artificial nerve guides in this rabbit model, with the hope of maximizing its translational potential in evaluating devices commonly used in hand and wrist surgery. The authors suggest replacing the less translational rat model with the rabbit model in nerve regeneration research, highlighting the need for effective strategies to prevent foot self-mutilation and pressure ulcers in the rabbit sciatic model.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Article
Engineering, Biomedical
Fadong Liu, Fei Hao, Peng Hao, Wen Zhao, Yudan Gao, Hongmei Duan, Zhaoyang Yang, Xiaoguang Li
Summary: A novel chitosan scaffold loaded with bFGF was used to successfully repair a 20 mm sciatic nerve defect in adult rats, promoting nerve regeneration and behavioral recovery. The approach showed great potential for clinical application in treating peripheral nerve injuries.
BIOMEDICAL MATERIALS
(2021)
Article
Environmental Sciences
Bin Bin Wang, Chao Guo, Sheng Qiao Sun, Xing Nan Zhang, Zhen Li, Wei Jie Li, De Zhi Li, Michael Schumacher, Song Liu
Summary: This study compared the effect of different peripheral nerve injury models on nerve regeneration through animal experiments. It was found that the regeneration speed was faster in the crush injury model, while it was slower in the transection injury model. This provides some reference for the selection of clinical research models.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sung-Tak Lee, Yoon-Seo Jang, Uk-Kyu Kim, Hyung-Joon Kim, Mi-Heon Ryu, Gyoo-Cheon Kim, Dae-Seok Hwang
Summary: This experimental research investigated the effects of non-thermal plasma on nerve regeneration in rats with transected sciatic nerve damage. The results showed that non-thermal plasma enhanced motor function and restored neuronal structure by accelerating myelination and axonal regeneration, indicating a positive effect on the recovery of sciatic nerve transected injury in rats.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Young Jun Kim, Kyu Jin Kim, Jae Hoon Lee, Seong-Uk Park, Seung-Yeon Cho
Summary: Experimental studies using herbal extracts in a rat sciatic nerve injury model showed that Coptis japonica extract increased nerve conduction velocity, Aconitum carmichaelii extract increased proximal and distal amplitudes, while decreasing neuroma and scar tissue formation.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)